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Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors

Immunotherapy has revolutionized the established therapeutics against tumors. As the major immunotherapy approach, immune checkpoint inhibitors (ICIs) achieved remarkable success in the treatment of malignancies. However, the clinical gains are far from universal and durable, because of the primary...

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Autores principales: Zhang, Xin, Li, Huiqin, Lv, Xiupeng, Hu, Li, Li, Wen, Zi, Meiting, He, Yonghan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951256/
https://www.ncbi.nlm.nih.gov/pubmed/35330159
http://dx.doi.org/10.3390/life12030409
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author Zhang, Xin
Li, Huiqin
Lv, Xiupeng
Hu, Li
Li, Wen
Zi, Meiting
He, Yonghan
author_facet Zhang, Xin
Li, Huiqin
Lv, Xiupeng
Hu, Li
Li, Wen
Zi, Meiting
He, Yonghan
author_sort Zhang, Xin
collection PubMed
description Immunotherapy has revolutionized the established therapeutics against tumors. As the major immunotherapy approach, immune checkpoint inhibitors (ICIs) achieved remarkable success in the treatment of malignancies. However, the clinical gains are far from universal and durable, because of the primary and secondary resistance of tumors to the therapy, or side effects induced by ICIs. There is an urgent need to find safe combinatorial strategies that enhance the response of ICIs for tumor treatment. Diets have an excellent safety profile and have been shown to play pleiotropic roles in tumor prevention, growth, invasion, and metastasis. Accumulating evidence suggests that dietary regimens bolster not only the tolerability but also the efficacy of tumor immunotherapy. In this review, we discussed the mechanisms by which tumor cells evade immune surveillance, focusing on describing the intrinsic and extrinsic mechanisms of resistance to ICIs. We also summarized the impacts of different diets and/or nutrients on the response to ICIs therapy. Combinatory treatments of ICIs therapy with optimized diet regimens own great potential to enhance the efficacy and durable response of ICIs against tumors, which should be routinely considered in clinical settings.
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spelling pubmed-89512562022-03-26 Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors Zhang, Xin Li, Huiqin Lv, Xiupeng Hu, Li Li, Wen Zi, Meiting He, Yonghan Life (Basel) Review Immunotherapy has revolutionized the established therapeutics against tumors. As the major immunotherapy approach, immune checkpoint inhibitors (ICIs) achieved remarkable success in the treatment of malignancies. However, the clinical gains are far from universal and durable, because of the primary and secondary resistance of tumors to the therapy, or side effects induced by ICIs. There is an urgent need to find safe combinatorial strategies that enhance the response of ICIs for tumor treatment. Diets have an excellent safety profile and have been shown to play pleiotropic roles in tumor prevention, growth, invasion, and metastasis. Accumulating evidence suggests that dietary regimens bolster not only the tolerability but also the efficacy of tumor immunotherapy. In this review, we discussed the mechanisms by which tumor cells evade immune surveillance, focusing on describing the intrinsic and extrinsic mechanisms of resistance to ICIs. We also summarized the impacts of different diets and/or nutrients on the response to ICIs therapy. Combinatory treatments of ICIs therapy with optimized diet regimens own great potential to enhance the efficacy and durable response of ICIs against tumors, which should be routinely considered in clinical settings. MDPI 2022-03-11 /pmc/articles/PMC8951256/ /pubmed/35330159 http://dx.doi.org/10.3390/life12030409 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Xin
Li, Huiqin
Lv, Xiupeng
Hu, Li
Li, Wen
Zi, Meiting
He, Yonghan
Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors
title Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors
title_full Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors
title_fullStr Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors
title_full_unstemmed Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors
title_short Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors
title_sort impact of diets on response to immune checkpoint inhibitors (icis) therapy against tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951256/
https://www.ncbi.nlm.nih.gov/pubmed/35330159
http://dx.doi.org/10.3390/life12030409
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