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Liver Disease Screening and Hepatitis C Virus Elimination in Taiwan Rural Indigenous Townships: Village-By-Village Screening and Linking to Outreach Hepatology Care

Medical resources are limited for hepatitis C virus (HCV) elimination in rural indigenous areas of Taiwan. This study aimed to investigate liver disease risk and conduct a HCV elimination program in two rural indigenous townships. A program of village-by-village screening tests was conducted includi...

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Autores principales: Tien, Hui-Min, Cheng, Tai-Chung, Lien, Hsiao-Chu, Yang, Kuei-Fei, Shy, Cherng-Gueih, Chen, Yu-Ling, Hsu, Nien-Tzu, Lu, Sheng-Nan, Wang, Jing-Houng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951406/
https://www.ncbi.nlm.nih.gov/pubmed/35328957
http://dx.doi.org/10.3390/ijerph19063269
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author Tien, Hui-Min
Cheng, Tai-Chung
Lien, Hsiao-Chu
Yang, Kuei-Fei
Shy, Cherng-Gueih
Chen, Yu-Ling
Hsu, Nien-Tzu
Lu, Sheng-Nan
Wang, Jing-Houng
author_facet Tien, Hui-Min
Cheng, Tai-Chung
Lien, Hsiao-Chu
Yang, Kuei-Fei
Shy, Cherng-Gueih
Chen, Yu-Ling
Hsu, Nien-Tzu
Lu, Sheng-Nan
Wang, Jing-Houng
author_sort Tien, Hui-Min
collection PubMed
description Medical resources are limited for hepatitis C virus (HCV) elimination in rural indigenous areas of Taiwan. This study aimed to investigate liver disease risk and conduct a HCV elimination program in two rural indigenous townships. A program of village-by-village screening tests was conducted including hepatitis B virus surface antigen (HBsAg), antibody to HCV (anti-HCV) and gamma-glutamyl transferase (GGT), linking to outreach hepatology care at two indigenous townships (Laiyi and Mudan). Adult residents were invited to join this program. One hepatology specialist assessed liver disease risk, provided HCV treatment counselling and initiated direct acting antivirals (DAA) at an outreach hepatology clinic in primary health centers. A total of 3503 residents attended this program with a screening coverage of 73.5%. The prevalence of HBsAg, anti-HCV, and high GGT level was 8.2%, 10.0% and 19.5%, respectively. Laiyi had significantly higher prevalence of anti-HCV than Mudan. While males had significantly higher prevalence of HBsAg and high GGT in both townships, females in Laiyi had higher anti-HCV prevalence. HBsAg and high GGT prevalence peaked at 40–59 years of age and anti-HCV prevalence increased significantly with age. Two hundred and sixty-three residents visited the outreach hepatology clinic for HCV treatment evaluation, with 121 (46%) residents having active HCV, while 116 received DAA, with 111 (95.7%) achieving HCV elimination. For rural indigenous townships in southern Taiwan, HCV infection and alcohol consumption were two major liver disease risks. While HCV infection was predominant in old females, chronic hepatitis B virus infection and habitual alcohol consumptions predominated in middle-aged males. HCV elimination was achieved by the village-by-village screening model and linked to outreach hepatology care.
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spelling pubmed-89514062022-03-26 Liver Disease Screening and Hepatitis C Virus Elimination in Taiwan Rural Indigenous Townships: Village-By-Village Screening and Linking to Outreach Hepatology Care Tien, Hui-Min Cheng, Tai-Chung Lien, Hsiao-Chu Yang, Kuei-Fei Shy, Cherng-Gueih Chen, Yu-Ling Hsu, Nien-Tzu Lu, Sheng-Nan Wang, Jing-Houng Int J Environ Res Public Health Article Medical resources are limited for hepatitis C virus (HCV) elimination in rural indigenous areas of Taiwan. This study aimed to investigate liver disease risk and conduct a HCV elimination program in two rural indigenous townships. A program of village-by-village screening tests was conducted including hepatitis B virus surface antigen (HBsAg), antibody to HCV (anti-HCV) and gamma-glutamyl transferase (GGT), linking to outreach hepatology care at two indigenous townships (Laiyi and Mudan). Adult residents were invited to join this program. One hepatology specialist assessed liver disease risk, provided HCV treatment counselling and initiated direct acting antivirals (DAA) at an outreach hepatology clinic in primary health centers. A total of 3503 residents attended this program with a screening coverage of 73.5%. The prevalence of HBsAg, anti-HCV, and high GGT level was 8.2%, 10.0% and 19.5%, respectively. Laiyi had significantly higher prevalence of anti-HCV than Mudan. While males had significantly higher prevalence of HBsAg and high GGT in both townships, females in Laiyi had higher anti-HCV prevalence. HBsAg and high GGT prevalence peaked at 40–59 years of age and anti-HCV prevalence increased significantly with age. Two hundred and sixty-three residents visited the outreach hepatology clinic for HCV treatment evaluation, with 121 (46%) residents having active HCV, while 116 received DAA, with 111 (95.7%) achieving HCV elimination. For rural indigenous townships in southern Taiwan, HCV infection and alcohol consumption were two major liver disease risks. While HCV infection was predominant in old females, chronic hepatitis B virus infection and habitual alcohol consumptions predominated in middle-aged males. HCV elimination was achieved by the village-by-village screening model and linked to outreach hepatology care. MDPI 2022-03-10 /pmc/articles/PMC8951406/ /pubmed/35328957 http://dx.doi.org/10.3390/ijerph19063269 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tien, Hui-Min
Cheng, Tai-Chung
Lien, Hsiao-Chu
Yang, Kuei-Fei
Shy, Cherng-Gueih
Chen, Yu-Ling
Hsu, Nien-Tzu
Lu, Sheng-Nan
Wang, Jing-Houng
Liver Disease Screening and Hepatitis C Virus Elimination in Taiwan Rural Indigenous Townships: Village-By-Village Screening and Linking to Outreach Hepatology Care
title Liver Disease Screening and Hepatitis C Virus Elimination in Taiwan Rural Indigenous Townships: Village-By-Village Screening and Linking to Outreach Hepatology Care
title_full Liver Disease Screening and Hepatitis C Virus Elimination in Taiwan Rural Indigenous Townships: Village-By-Village Screening and Linking to Outreach Hepatology Care
title_fullStr Liver Disease Screening and Hepatitis C Virus Elimination in Taiwan Rural Indigenous Townships: Village-By-Village Screening and Linking to Outreach Hepatology Care
title_full_unstemmed Liver Disease Screening and Hepatitis C Virus Elimination in Taiwan Rural Indigenous Townships: Village-By-Village Screening and Linking to Outreach Hepatology Care
title_short Liver Disease Screening and Hepatitis C Virus Elimination in Taiwan Rural Indigenous Townships: Village-By-Village Screening and Linking to Outreach Hepatology Care
title_sort liver disease screening and hepatitis c virus elimination in taiwan rural indigenous townships: village-by-village screening and linking to outreach hepatology care
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951406/
https://www.ncbi.nlm.nih.gov/pubmed/35328957
http://dx.doi.org/10.3390/ijerph19063269
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