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Is a Patient with Paget’s Disease of Bone Suitable for Living Kidney Donation?—Decision-Making in Lack of Clinical Evidence

Living donor kidney transplantation is a widely performed medical procedure. Living kidney donation requires an in-depth health assessment of candidates. The potential living kidney donor must remain healthy after kidney removal. A consequence of donation can be a decrease in glomerular filtration r...

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Detalles Bibliográficos
Autores principales: Poznański, Paweł, Lepiesza, Agnieszka, Jędrzejuk, Diana, Mazanowska, Oktawia, Bolanowski, Marek, Krajewska, Magdalena, Kamińska, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951425/
https://www.ncbi.nlm.nih.gov/pubmed/35329811
http://dx.doi.org/10.3390/jcm11061485
Descripción
Sumario:Living donor kidney transplantation is a widely performed medical procedure. Living kidney donation requires an in-depth health assessment of candidates. The potential living kidney donor must remain healthy after kidney removal. A consequence of donation can be a decrease in glomerular filtration rate (GFR), and donors can become at risk of developing chronic kidney disease (CKD). We present a rationale for potential living kidney donor withdrawal due to Paget’s disease of bone (PDB) based on a literature review. The treatment for PDB includes the use of, for example, non-steroidal anti-inflammatory drugs (NSAIDs), which can lead to acute kidney injury (AKI) as well as CKD, or bisphosphonates, which are not recommended for patients with decreased GFR.