Cargando…
Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release
Polysaccharides are attractive gelling agents in pharmacy due to their safety, biocompatibility, biodegradability, relatively easy way of preparation, and low price. Due to their variable physical-chemical properties, polysaccharides have potentialities to be used for designing new drug delivery sys...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951473/ https://www.ncbi.nlm.nih.gov/pubmed/35323281 http://dx.doi.org/10.3390/gels8030168 |
_version_ | 1784675395179642880 |
---|---|
author | Mikušová, Veronika Ferková, Jarmila Žigrayová, Dominika Krchňák, Daniel Mikuš, Peter |
author_facet | Mikušová, Veronika Ferková, Jarmila Žigrayová, Dominika Krchňák, Daniel Mikuš, Peter |
author_sort | Mikušová, Veronika |
collection | PubMed |
description | Polysaccharides are attractive gelling agents in pharmacy due to their safety, biocompatibility, biodegradability, relatively easy way of preparation, and low price. Due to their variable physical-chemical properties, polysaccharides have potentialities to be used for designing new drug delivery systems for controlled drug release. In this comparative study, rheological and texture properties as well as the in vitro release of model drug ibuprofen (IBU) with 11 polysaccharide-based hydrogels were investigated. The in vitro release of IBU significantly differed between (i) neutral (hydroxy/alkylcelluloses), (ii) anionic (carboxyalkylcellulose and its sodium salt, tragacanth, carrageenan, xanthan gum), and (iii) cationic (chitosans) hydrogels due to different contribution of provided interactions and viscosity within the hydrogel groups. The drug release kinetics of each hydrogel system was evaluated for five kinetic models. Several combinations of cationic hydrogels with neutral or anionic ones were performed to illustrate possibilities of providing modified IBU release profiles. In this context, chitosan was presented as an effective modifier of diffusion profiles for negatively charged drugs formulated into combined polymeric systems, providing their prolonged release. The most appropriate hydrogel for the topical application (i.e., providing favorable rheological and texture properties along with the highest drug release) was selected from a studied series of polysaccharide-based hydrogels. |
format | Online Article Text |
id | pubmed-8951473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89514732022-03-26 Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release Mikušová, Veronika Ferková, Jarmila Žigrayová, Dominika Krchňák, Daniel Mikuš, Peter Gels Article Polysaccharides are attractive gelling agents in pharmacy due to their safety, biocompatibility, biodegradability, relatively easy way of preparation, and low price. Due to their variable physical-chemical properties, polysaccharides have potentialities to be used for designing new drug delivery systems for controlled drug release. In this comparative study, rheological and texture properties as well as the in vitro release of model drug ibuprofen (IBU) with 11 polysaccharide-based hydrogels were investigated. The in vitro release of IBU significantly differed between (i) neutral (hydroxy/alkylcelluloses), (ii) anionic (carboxyalkylcellulose and its sodium salt, tragacanth, carrageenan, xanthan gum), and (iii) cationic (chitosans) hydrogels due to different contribution of provided interactions and viscosity within the hydrogel groups. The drug release kinetics of each hydrogel system was evaluated for five kinetic models. Several combinations of cationic hydrogels with neutral or anionic ones were performed to illustrate possibilities of providing modified IBU release profiles. In this context, chitosan was presented as an effective modifier of diffusion profiles for negatively charged drugs formulated into combined polymeric systems, providing their prolonged release. The most appropriate hydrogel for the topical application (i.e., providing favorable rheological and texture properties along with the highest drug release) was selected from a studied series of polysaccharide-based hydrogels. MDPI 2022-03-07 /pmc/articles/PMC8951473/ /pubmed/35323281 http://dx.doi.org/10.3390/gels8030168 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mikušová, Veronika Ferková, Jarmila Žigrayová, Dominika Krchňák, Daniel Mikuš, Peter Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release |
title | Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release |
title_full | Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release |
title_fullStr | Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release |
title_full_unstemmed | Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release |
title_short | Comparative Study of Polysaccharide-Based Hydrogels: Rheological and Texture Properties and Ibuprofen Release |
title_sort | comparative study of polysaccharide-based hydrogels: rheological and texture properties and ibuprofen release |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951473/ https://www.ncbi.nlm.nih.gov/pubmed/35323281 http://dx.doi.org/10.3390/gels8030168 |
work_keys_str_mv | AT mikusovaveronika comparativestudyofpolysaccharidebasedhydrogelsrheologicalandtexturepropertiesandibuprofenrelease AT ferkovajarmila comparativestudyofpolysaccharidebasedhydrogelsrheologicalandtexturepropertiesandibuprofenrelease AT zigrayovadominika comparativestudyofpolysaccharidebasedhydrogelsrheologicalandtexturepropertiesandibuprofenrelease AT krchnakdaniel comparativestudyofpolysaccharidebasedhydrogelsrheologicalandtexturepropertiesandibuprofenrelease AT mikuspeter comparativestudyofpolysaccharidebasedhydrogelsrheologicalandtexturepropertiesandibuprofenrelease |