Mitigating Benzodiazepine Dependence and the Risk of Drug-Induced QTc Prolongation in the Treatment of Gastroparesis: A Case Report

Patients are often faced with challenges when it comes to safe therapeutic options. An 89-year-old female with a history of arrhythmias and refractory gastroparesis complained of adverse drug events from her benzodiazepine. While performing a comprehensive medication review and a medication safety r...

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Detalles Bibliográficos
Autores principales: Tranchina, Karley, Matlock, Derek, Hernandez, Carlos, Turgeon, Jacques, Bingham, Jennifer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951483/
https://www.ncbi.nlm.nih.gov/pubmed/35334585
http://dx.doi.org/10.3390/medicina58030409
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author Tranchina, Karley
Matlock, Derek
Hernandez, Carlos
Turgeon, Jacques
Bingham, Jennifer M.
author_facet Tranchina, Karley
Matlock, Derek
Hernandez, Carlos
Turgeon, Jacques
Bingham, Jennifer M.
author_sort Tranchina, Karley
collection PubMed
description Patients are often faced with challenges when it comes to safe therapeutic options. An 89-year-old female with a history of arrhythmias and refractory gastroparesis complained of adverse drug events from her benzodiazepine. While performing a comprehensive medication review and a medication safety review using an advanced clinical decision support system, the pharmacist successfully tapered off the benzodiazepine to a safer alternative antidepressant indicated for the treatment of gastroparesis. Special attention was given to selecting drugs with less QT prolongation risk, based on her age, current drug regimen, previous medical history, and presence of polypharmacy.
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spelling pubmed-89514832022-03-26 Mitigating Benzodiazepine Dependence and the Risk of Drug-Induced QTc Prolongation in the Treatment of Gastroparesis: A Case Report Tranchina, Karley Matlock, Derek Hernandez, Carlos Turgeon, Jacques Bingham, Jennifer M. Medicina (Kaunas) Case Report Patients are often faced with challenges when it comes to safe therapeutic options. An 89-year-old female with a history of arrhythmias and refractory gastroparesis complained of adverse drug events from her benzodiazepine. While performing a comprehensive medication review and a medication safety review using an advanced clinical decision support system, the pharmacist successfully tapered off the benzodiazepine to a safer alternative antidepressant indicated for the treatment of gastroparesis. Special attention was given to selecting drugs with less QT prolongation risk, based on her age, current drug regimen, previous medical history, and presence of polypharmacy. MDPI 2022-03-10 /pmc/articles/PMC8951483/ /pubmed/35334585 http://dx.doi.org/10.3390/medicina58030409 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Tranchina, Karley
Matlock, Derek
Hernandez, Carlos
Turgeon, Jacques
Bingham, Jennifer M.
Mitigating Benzodiazepine Dependence and the Risk of Drug-Induced QTc Prolongation in the Treatment of Gastroparesis: A Case Report
title Mitigating Benzodiazepine Dependence and the Risk of Drug-Induced QTc Prolongation in the Treatment of Gastroparesis: A Case Report
title_full Mitigating Benzodiazepine Dependence and the Risk of Drug-Induced QTc Prolongation in the Treatment of Gastroparesis: A Case Report
title_fullStr Mitigating Benzodiazepine Dependence and the Risk of Drug-Induced QTc Prolongation in the Treatment of Gastroparesis: A Case Report
title_full_unstemmed Mitigating Benzodiazepine Dependence and the Risk of Drug-Induced QTc Prolongation in the Treatment of Gastroparesis: A Case Report
title_short Mitigating Benzodiazepine Dependence and the Risk of Drug-Induced QTc Prolongation in the Treatment of Gastroparesis: A Case Report
title_sort mitigating benzodiazepine dependence and the risk of drug-induced qtc prolongation in the treatment of gastroparesis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951483/
https://www.ncbi.nlm.nih.gov/pubmed/35334585
http://dx.doi.org/10.3390/medicina58030409
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