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Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy
A percutaneous renal biopsy is an essential tool for the diagnosis of various renal diseases; however, post-biopsy bleeding is a major complication. Hemocoagulase is a detoxified and purified snake venom enzyme that is widely used to prevent post-procedural bleeding. In this study, we retrospectivel...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951486/ https://www.ncbi.nlm.nih.gov/pubmed/35324720 http://dx.doi.org/10.3390/toxins14030223 |
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author | Torigoe, Kenta Yamashita, Ayuko Abe, Shinichi Muta, Kumiko Mukae, Hiroshi Nishino, Tomoya |
author_facet | Torigoe, Kenta Yamashita, Ayuko Abe, Shinichi Muta, Kumiko Mukae, Hiroshi Nishino, Tomoya |
author_sort | Torigoe, Kenta |
collection | PubMed |
description | A percutaneous renal biopsy is an essential tool for the diagnosis of various renal diseases; however, post-biopsy bleeding is a major complication. Hemocoagulase is a detoxified and purified snake venom enzyme that is widely used to prevent post-procedural bleeding. In this study, we retrospectively analyzed the effect of hemocoagulase on post-renal biopsy bleeding. We included 221 patients who underwent percutaneous renal biopsy between April 2017 and December 2020 and analyzed post-renal biopsy hemoglobin (Hb) decline in patients who were administered a periprocedural hemocoagulase injection. After the renal biopsy, the mean Hb decrease in the entire patient cohort was 0.33 ± 0.84 g/dL. Periprocedural hemocoagulase injection lowered the Hb decline post-renal biopsy (0.50 ± 0.87 vs. 0.23 ± 0.80 g/dL, p = 0.0204). The propensity-matched cohort was also adjusted for factors influencing postprocedural bleeding; periprocedural hemocoagulase injection reduced the Hb decline post-renal biopsy (0.56 ± 0.89 vs. 0.17 ± 0.74 g/dL, p = 0.006). There were no adverse events (e.g., thrombosis and anaphylactic shock) due to hemocoagulase. Our study demonstrated the beneficial effect of hemocoagulase on post-renal biopsy Hb decline, suggesting its clinical value in preventing post-renal biopsy bleeding. |
format | Online Article Text |
id | pubmed-8951486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89514862022-03-26 Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy Torigoe, Kenta Yamashita, Ayuko Abe, Shinichi Muta, Kumiko Mukae, Hiroshi Nishino, Tomoya Toxins (Basel) Article A percutaneous renal biopsy is an essential tool for the diagnosis of various renal diseases; however, post-biopsy bleeding is a major complication. Hemocoagulase is a detoxified and purified snake venom enzyme that is widely used to prevent post-procedural bleeding. In this study, we retrospectively analyzed the effect of hemocoagulase on post-renal biopsy bleeding. We included 221 patients who underwent percutaneous renal biopsy between April 2017 and December 2020 and analyzed post-renal biopsy hemoglobin (Hb) decline in patients who were administered a periprocedural hemocoagulase injection. After the renal biopsy, the mean Hb decrease in the entire patient cohort was 0.33 ± 0.84 g/dL. Periprocedural hemocoagulase injection lowered the Hb decline post-renal biopsy (0.50 ± 0.87 vs. 0.23 ± 0.80 g/dL, p = 0.0204). The propensity-matched cohort was also adjusted for factors influencing postprocedural bleeding; periprocedural hemocoagulase injection reduced the Hb decline post-renal biopsy (0.56 ± 0.89 vs. 0.17 ± 0.74 g/dL, p = 0.006). There were no adverse events (e.g., thrombosis and anaphylactic shock) due to hemocoagulase. Our study demonstrated the beneficial effect of hemocoagulase on post-renal biopsy Hb decline, suggesting its clinical value in preventing post-renal biopsy bleeding. MDPI 2022-03-18 /pmc/articles/PMC8951486/ /pubmed/35324720 http://dx.doi.org/10.3390/toxins14030223 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Torigoe, Kenta Yamashita, Ayuko Abe, Shinichi Muta, Kumiko Mukae, Hiroshi Nishino, Tomoya Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy |
title | Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy |
title_full | Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy |
title_fullStr | Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy |
title_full_unstemmed | Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy |
title_short | Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy |
title_sort | effect of hemocoagulase on the prevention of bleeding after percutaneous renal biopsy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951486/ https://www.ncbi.nlm.nih.gov/pubmed/35324720 http://dx.doi.org/10.3390/toxins14030223 |
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