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Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy

A percutaneous renal biopsy is an essential tool for the diagnosis of various renal diseases; however, post-biopsy bleeding is a major complication. Hemocoagulase is a detoxified and purified snake venom enzyme that is widely used to prevent post-procedural bleeding. In this study, we retrospectivel...

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Autores principales: Torigoe, Kenta, Yamashita, Ayuko, Abe, Shinichi, Muta, Kumiko, Mukae, Hiroshi, Nishino, Tomoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951486/
https://www.ncbi.nlm.nih.gov/pubmed/35324720
http://dx.doi.org/10.3390/toxins14030223
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author Torigoe, Kenta
Yamashita, Ayuko
Abe, Shinichi
Muta, Kumiko
Mukae, Hiroshi
Nishino, Tomoya
author_facet Torigoe, Kenta
Yamashita, Ayuko
Abe, Shinichi
Muta, Kumiko
Mukae, Hiroshi
Nishino, Tomoya
author_sort Torigoe, Kenta
collection PubMed
description A percutaneous renal biopsy is an essential tool for the diagnosis of various renal diseases; however, post-biopsy bleeding is a major complication. Hemocoagulase is a detoxified and purified snake venom enzyme that is widely used to prevent post-procedural bleeding. In this study, we retrospectively analyzed the effect of hemocoagulase on post-renal biopsy bleeding. We included 221 patients who underwent percutaneous renal biopsy between April 2017 and December 2020 and analyzed post-renal biopsy hemoglobin (Hb) decline in patients who were administered a periprocedural hemocoagulase injection. After the renal biopsy, the mean Hb decrease in the entire patient cohort was 0.33 ± 0.84 g/dL. Periprocedural hemocoagulase injection lowered the Hb decline post-renal biopsy (0.50 ± 0.87 vs. 0.23 ± 0.80 g/dL, p = 0.0204). The propensity-matched cohort was also adjusted for factors influencing postprocedural bleeding; periprocedural hemocoagulase injection reduced the Hb decline post-renal biopsy (0.56 ± 0.89 vs. 0.17 ± 0.74 g/dL, p = 0.006). There were no adverse events (e.g., thrombosis and anaphylactic shock) due to hemocoagulase. Our study demonstrated the beneficial effect of hemocoagulase on post-renal biopsy Hb decline, suggesting its clinical value in preventing post-renal biopsy bleeding.
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spelling pubmed-89514862022-03-26 Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy Torigoe, Kenta Yamashita, Ayuko Abe, Shinichi Muta, Kumiko Mukae, Hiroshi Nishino, Tomoya Toxins (Basel) Article A percutaneous renal biopsy is an essential tool for the diagnosis of various renal diseases; however, post-biopsy bleeding is a major complication. Hemocoagulase is a detoxified and purified snake venom enzyme that is widely used to prevent post-procedural bleeding. In this study, we retrospectively analyzed the effect of hemocoagulase on post-renal biopsy bleeding. We included 221 patients who underwent percutaneous renal biopsy between April 2017 and December 2020 and analyzed post-renal biopsy hemoglobin (Hb) decline in patients who were administered a periprocedural hemocoagulase injection. After the renal biopsy, the mean Hb decrease in the entire patient cohort was 0.33 ± 0.84 g/dL. Periprocedural hemocoagulase injection lowered the Hb decline post-renal biopsy (0.50 ± 0.87 vs. 0.23 ± 0.80 g/dL, p = 0.0204). The propensity-matched cohort was also adjusted for factors influencing postprocedural bleeding; periprocedural hemocoagulase injection reduced the Hb decline post-renal biopsy (0.56 ± 0.89 vs. 0.17 ± 0.74 g/dL, p = 0.006). There were no adverse events (e.g., thrombosis and anaphylactic shock) due to hemocoagulase. Our study demonstrated the beneficial effect of hemocoagulase on post-renal biopsy Hb decline, suggesting its clinical value in preventing post-renal biopsy bleeding. MDPI 2022-03-18 /pmc/articles/PMC8951486/ /pubmed/35324720 http://dx.doi.org/10.3390/toxins14030223 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Torigoe, Kenta
Yamashita, Ayuko
Abe, Shinichi
Muta, Kumiko
Mukae, Hiroshi
Nishino, Tomoya
Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy
title Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy
title_full Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy
title_fullStr Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy
title_full_unstemmed Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy
title_short Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy
title_sort effect of hemocoagulase on the prevention of bleeding after percutaneous renal biopsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951486/
https://www.ncbi.nlm.nih.gov/pubmed/35324720
http://dx.doi.org/10.3390/toxins14030223
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