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Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide

This study aims to compare the hardness, sorption and solubility of commercially available tissue conditioner [TC] modified with chitosan [CS] and synthesized chitosan oligosaccharide [COS] in antifungal concentration. COS was synthesized by acid hydrolysis and characterized by FTIR and XRD. Experim...

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Autores principales: Saeed, Asfia, Zahid, Shahreen, Sajid, Muhammad, Ud Din, Shahab, Alam, Mohammad Khursheed, Chaudhary, Farooq Ahmad, Kaleem, Muhammad, Alswairki, Haytham Jamil, Abutayyem, Huda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951559/
https://www.ncbi.nlm.nih.gov/pubmed/35335563
http://dx.doi.org/10.3390/polym14061233
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author Saeed, Asfia
Zahid, Shahreen
Sajid, Muhammad
Ud Din, Shahab
Alam, Mohammad Khursheed
Chaudhary, Farooq Ahmad
Kaleem, Muhammad
Alswairki, Haytham Jamil
Abutayyem, Huda
author_facet Saeed, Asfia
Zahid, Shahreen
Sajid, Muhammad
Ud Din, Shahab
Alam, Mohammad Khursheed
Chaudhary, Farooq Ahmad
Kaleem, Muhammad
Alswairki, Haytham Jamil
Abutayyem, Huda
author_sort Saeed, Asfia
collection PubMed
description This study aims to compare the hardness, sorption and solubility of commercially available tissue conditioner [TC] modified with chitosan [CS] and synthesized chitosan oligosaccharide [COS] in antifungal concentration. COS was synthesized by acid hydrolysis and characterized by FTIR and XRD. Experimental materials were formulated by incorporating each per gram of TC powder with effective antifungal concentration of chitosan 1.02 mg (Group 1: TC-CS) and 0.51 mg COS (Group 2: TC-COS). A commercially available TC was used as control (Group 0: CTC). Shore A hardness test was performed according to ASTM D 2240-05 (2010) standards on samples stored in dry environment, distilled water (DW) and artificial saliva (AS) at 37 °C (n = 5 per group). Percent weight changes (n = 5 per group) after storage in DW and AS was used to record sorption and solubility. One-way Anova with post hoc Tukey’s test was applied. FTIR and XRD confirmed low molecular weight and amorphous nature of COS. Experimental groups had higher Shore A hardness values; however, these changes were not significant. Greatest variations in durometer values (p ≤ 0.05) were observed during the first 24 h. Experimental groups had higher (p ≤ 0.05) percentage sorption and solubility. Samples stored in DW had significantly higher (p = 0.019) sorption, whereas material had higher (p = 0.005) solubility in AS. Mean solubility values in both immersion mediums was highest for Group 2, followed by group 1 and group 0. In addition, significant (p ≤ 0.05) increase in solubility upon aging was noted for each material. Experimental tissue conditioner had higher hardness, sorption and solubility. However, these changes are not substantial to interfere with their tissue healing property. Therefore, these materials may be considered and explored further as potential antimicrobial drug delivery agent for denture stomatitis patients.
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spelling pubmed-89515592022-03-26 Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide Saeed, Asfia Zahid, Shahreen Sajid, Muhammad Ud Din, Shahab Alam, Mohammad Khursheed Chaudhary, Farooq Ahmad Kaleem, Muhammad Alswairki, Haytham Jamil Abutayyem, Huda Polymers (Basel) Article This study aims to compare the hardness, sorption and solubility of commercially available tissue conditioner [TC] modified with chitosan [CS] and synthesized chitosan oligosaccharide [COS] in antifungal concentration. COS was synthesized by acid hydrolysis and characterized by FTIR and XRD. Experimental materials were formulated by incorporating each per gram of TC powder with effective antifungal concentration of chitosan 1.02 mg (Group 1: TC-CS) and 0.51 mg COS (Group 2: TC-COS). A commercially available TC was used as control (Group 0: CTC). Shore A hardness test was performed according to ASTM D 2240-05 (2010) standards on samples stored in dry environment, distilled water (DW) and artificial saliva (AS) at 37 °C (n = 5 per group). Percent weight changes (n = 5 per group) after storage in DW and AS was used to record sorption and solubility. One-way Anova with post hoc Tukey’s test was applied. FTIR and XRD confirmed low molecular weight and amorphous nature of COS. Experimental groups had higher Shore A hardness values; however, these changes were not significant. Greatest variations in durometer values (p ≤ 0.05) were observed during the first 24 h. Experimental groups had higher (p ≤ 0.05) percentage sorption and solubility. Samples stored in DW had significantly higher (p = 0.019) sorption, whereas material had higher (p = 0.005) solubility in AS. Mean solubility values in both immersion mediums was highest for Group 2, followed by group 1 and group 0. In addition, significant (p ≤ 0.05) increase in solubility upon aging was noted for each material. Experimental tissue conditioner had higher hardness, sorption and solubility. However, these changes are not substantial to interfere with their tissue healing property. Therefore, these materials may be considered and explored further as potential antimicrobial drug delivery agent for denture stomatitis patients. MDPI 2022-03-18 /pmc/articles/PMC8951559/ /pubmed/35335563 http://dx.doi.org/10.3390/polym14061233 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Saeed, Asfia
Zahid, Shahreen
Sajid, Muhammad
Ud Din, Shahab
Alam, Mohammad Khursheed
Chaudhary, Farooq Ahmad
Kaleem, Muhammad
Alswairki, Haytham Jamil
Abutayyem, Huda
Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide
title Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide
title_full Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide
title_fullStr Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide
title_full_unstemmed Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide
title_short Physico-Mechanical Properties of Commercially Available Tissue Conditioner Modified with Synthesized Chitosan Oligosaccharide
title_sort physico-mechanical properties of commercially available tissue conditioner modified with synthesized chitosan oligosaccharide
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951559/
https://www.ncbi.nlm.nih.gov/pubmed/35335563
http://dx.doi.org/10.3390/polym14061233
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