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T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review

Cellular immunity against rotavirus in children is incompletely understood. This review describes the current understanding of T-cell immunity to rotavirus in children. A systematic literature search was conducted in Embase, MEDLINE, Web of Science, and Global Health databases using a combination of...

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Autores principales: Laban, Natasha Makabilo, Goodier, Martin Rhys, Bosomprah, Samuel, Simuyandi, Michelo, Chisenga, Caroline, Chilyabanyama, Obvious Nchimunya, Chilengi, Roma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951614/
https://www.ncbi.nlm.nih.gov/pubmed/35336866
http://dx.doi.org/10.3390/v14030459
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author Laban, Natasha Makabilo
Goodier, Martin Rhys
Bosomprah, Samuel
Simuyandi, Michelo
Chisenga, Caroline
Chilyabanyama, Obvious Nchimunya
Chilengi, Roma
author_facet Laban, Natasha Makabilo
Goodier, Martin Rhys
Bosomprah, Samuel
Simuyandi, Michelo
Chisenga, Caroline
Chilyabanyama, Obvious Nchimunya
Chilengi, Roma
author_sort Laban, Natasha Makabilo
collection PubMed
description Cellular immunity against rotavirus in children is incompletely understood. This review describes the current understanding of T-cell immunity to rotavirus in children. A systematic literature search was conducted in Embase, MEDLINE, Web of Science, and Global Health databases using a combination of “t-cell”, “rotavirus” and “child” keywords to extract data from relevant articles published from January 1973 to March 2020. Only seventeen articles were identified. Rotavirus-specific T-cell immunity in children develops and broadens reactivity with increasing age. Whilst occurring in close association with antibody responses, T-cell responses are more transient but can occur in absence of detectable antibody responses. Rotavirus-induced T-cell immunity is largely of the gut homing phenotype and predominantly involves Th1 and cytotoxic subsets that may be influenced by IL-10 Tregs. However, rotavirus-specific T-cell responses in children are generally of low frequencies in peripheral blood and are limited in comparison to other infecting pathogens and in adults. The available research reviewed here characterizes the T-cell immune response in children. There is a need for further research investigating the protective associations of rotavirus-specific T-cell responses against infection or vaccination and the standardization of rotavirus-specific T-cells assays in children.
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spelling pubmed-89516142022-03-26 T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review Laban, Natasha Makabilo Goodier, Martin Rhys Bosomprah, Samuel Simuyandi, Michelo Chisenga, Caroline Chilyabanyama, Obvious Nchimunya Chilengi, Roma Viruses Review Cellular immunity against rotavirus in children is incompletely understood. This review describes the current understanding of T-cell immunity to rotavirus in children. A systematic literature search was conducted in Embase, MEDLINE, Web of Science, and Global Health databases using a combination of “t-cell”, “rotavirus” and “child” keywords to extract data from relevant articles published from January 1973 to March 2020. Only seventeen articles were identified. Rotavirus-specific T-cell immunity in children develops and broadens reactivity with increasing age. Whilst occurring in close association with antibody responses, T-cell responses are more transient but can occur in absence of detectable antibody responses. Rotavirus-induced T-cell immunity is largely of the gut homing phenotype and predominantly involves Th1 and cytotoxic subsets that may be influenced by IL-10 Tregs. However, rotavirus-specific T-cell responses in children are generally of low frequencies in peripheral blood and are limited in comparison to other infecting pathogens and in adults. The available research reviewed here characterizes the T-cell immune response in children. There is a need for further research investigating the protective associations of rotavirus-specific T-cell responses against infection or vaccination and the standardization of rotavirus-specific T-cells assays in children. MDPI 2022-02-23 /pmc/articles/PMC8951614/ /pubmed/35336866 http://dx.doi.org/10.3390/v14030459 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Laban, Natasha Makabilo
Goodier, Martin Rhys
Bosomprah, Samuel
Simuyandi, Michelo
Chisenga, Caroline
Chilyabanyama, Obvious Nchimunya
Chilengi, Roma
T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review
title T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review
title_full T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review
title_fullStr T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review
title_full_unstemmed T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review
title_short T-Cell Responses after Rotavirus Infection or Vaccination in Children: A Systematic Review
title_sort t-cell responses after rotavirus infection or vaccination in children: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951614/
https://www.ncbi.nlm.nih.gov/pubmed/35336866
http://dx.doi.org/10.3390/v14030459
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