Cargando…

The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures

The greatest challenges of modern pharmacology are the design of drugs with the highest possible efficacy of an active substance and with the lowest possible invasiveness for the whole organism. A good solution features the application of a bioactive substance in different carriers. The effectivenes...

Descripción completa

Detalles Bibliográficos
Autores principales: Błaszczyk, Mariola M., Sęk, Jerzy, Przybysz, Łukasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951647/
https://www.ncbi.nlm.nih.gov/pubmed/35335961
http://dx.doi.org/10.3390/pharmaceutics14030585
_version_ 1784675439108685824
author Błaszczyk, Mariola M.
Sęk, Jerzy
Przybysz, Łukasz
author_facet Błaszczyk, Mariola M.
Sęk, Jerzy
Przybysz, Łukasz
author_sort Błaszczyk, Mariola M.
collection PubMed
description The greatest challenges of modern pharmacology are the design of drugs with the highest possible efficacy of an active substance and with the lowest possible invasiveness for the whole organism. A good solution features the application of a bioactive substance in different carriers. The effectiveness of such preparations is determined not only by the properties of the drug, but primarily by the dynamics of carrier movement in the body. This is the reason why studies on the dispersed systems transport in micro- and nanostructures are becoming important. This paper presents a study of emulsion systems transport in microcapillaries. A dispersed phase thickening effect was observed during the process, which resulted in a concentration increase of the flowing emulsion, in some cases up to 10 times. This phenomenon directly influences transport dynamics of such substances in microstructures and should be taken into account when designing drug parameters (concentration, release time, and action range). The effect was investigated for three different emulsions concentrations and presented quantitatively. The scales of this phenomenon occurrence at different flow conditions were investigated, and their magnitudes were modelled and described. This allows the prediction of the flow resistance in the movement of given dispersion systems, as a function of the flow rate, the emulsion parameters, and the microchannel size.
format Online
Article
Text
id pubmed-8951647
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89516472022-03-26 The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures Błaszczyk, Mariola M. Sęk, Jerzy Przybysz, Łukasz Pharmaceutics Article The greatest challenges of modern pharmacology are the design of drugs with the highest possible efficacy of an active substance and with the lowest possible invasiveness for the whole organism. A good solution features the application of a bioactive substance in different carriers. The effectiveness of such preparations is determined not only by the properties of the drug, but primarily by the dynamics of carrier movement in the body. This is the reason why studies on the dispersed systems transport in micro- and nanostructures are becoming important. This paper presents a study of emulsion systems transport in microcapillaries. A dispersed phase thickening effect was observed during the process, which resulted in a concentration increase of the flowing emulsion, in some cases up to 10 times. This phenomenon directly influences transport dynamics of such substances in microstructures and should be taken into account when designing drug parameters (concentration, release time, and action range). The effect was investigated for three different emulsions concentrations and presented quantitatively. The scales of this phenomenon occurrence at different flow conditions were investigated, and their magnitudes were modelled and described. This allows the prediction of the flow resistance in the movement of given dispersion systems, as a function of the flow rate, the emulsion parameters, and the microchannel size. MDPI 2022-03-08 /pmc/articles/PMC8951647/ /pubmed/35335961 http://dx.doi.org/10.3390/pharmaceutics14030585 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Błaszczyk, Mariola M.
Sęk, Jerzy
Przybysz, Łukasz
The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
title The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
title_full The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
title_fullStr The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
title_full_unstemmed The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
title_short The Phenomenon of Drug Emulsion Carriers Compaction during Their Movement in Microstructures
title_sort phenomenon of drug emulsion carriers compaction during their movement in microstructures
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951647/
https://www.ncbi.nlm.nih.gov/pubmed/35335961
http://dx.doi.org/10.3390/pharmaceutics14030585
work_keys_str_mv AT błaszczykmariolam thephenomenonofdrugemulsioncarrierscompactionduringtheirmovementinmicrostructures
AT sekjerzy thephenomenonofdrugemulsioncarrierscompactionduringtheirmovementinmicrostructures
AT przybyszłukasz thephenomenonofdrugemulsioncarrierscompactionduringtheirmovementinmicrostructures
AT błaszczykmariolam phenomenonofdrugemulsioncarrierscompactionduringtheirmovementinmicrostructures
AT sekjerzy phenomenonofdrugemulsioncarrierscompactionduringtheirmovementinmicrostructures
AT przybyszłukasz phenomenonofdrugemulsioncarrierscompactionduringtheirmovementinmicrostructures