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Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis

The tick-borne encephalitis virus (TBEV) causes a life-threatening disease named Tick-borne encephalitis (TBE). The clinical symptoms associated with TBE range from non-specific to severe inflammation of the central nervous system and are very similar to the clinical presentation of other viral meni...

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Autores principales: Banović, Pavle, Díaz-Sánchez, Adrian Alberto, Đurić, Selena, Sević, Siniša, Turkulov, Vesna, Lendak, Dajana, Mikić, Sandra Stefan, Simin, Verica, Mijatović, Dragana, Bogdan, Ivana, Potkonjak, Aleksandar, Savić, Sara, Obregón, Dasiel, Cabezas-Cruz, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951648/
https://www.ncbi.nlm.nih.gov/pubmed/35335695
http://dx.doi.org/10.3390/pathogens11030371
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author Banović, Pavle
Díaz-Sánchez, Adrian Alberto
Đurić, Selena
Sević, Siniša
Turkulov, Vesna
Lendak, Dajana
Mikić, Sandra Stefan
Simin, Verica
Mijatović, Dragana
Bogdan, Ivana
Potkonjak, Aleksandar
Savić, Sara
Obregón, Dasiel
Cabezas-Cruz, Alejandro
author_facet Banović, Pavle
Díaz-Sánchez, Adrian Alberto
Đurić, Selena
Sević, Siniša
Turkulov, Vesna
Lendak, Dajana
Mikić, Sandra Stefan
Simin, Verica
Mijatović, Dragana
Bogdan, Ivana
Potkonjak, Aleksandar
Savić, Sara
Obregón, Dasiel
Cabezas-Cruz, Alejandro
author_sort Banović, Pavle
collection PubMed
description The tick-borne encephalitis virus (TBEV) causes a life-threatening disease named Tick-borne encephalitis (TBE). The clinical symptoms associated with TBE range from non-specific to severe inflammation of the central nervous system and are very similar to the clinical presentation of other viral meningitis/encephalitis. In consequence, TBE is often misclassified by clinical physicians, mainly in the non-identified high-risk areas where none or only a few TBE cases have been reported. Considering this situation, we hypothesized that among persons from northern Serbia who recovered from viral meningitis or encephalitis, there would be evidence of TBEV infection. To test this hypothesis, in this observational study, we evaluated the seroreactivity against TBEV antigens in patients from northern Serbia who were hospitalized due to viral meningitis and/or viral encephalitis of unknown etiology. Three cases of seroreactivity to TBEV antigens were discovered among convalescent patients who recovered from viral meningitis and/or encephalitis and accepted to participate in the study (n = 15). The clinical and laboratory findings of these patients overlap with that of seronegative convalescent patients. Although TBE has been a notifiable disease in Serbia since 2004, there is no active TBE surveillance program for the serologic or molecular screening of TBEV infection in humans in the country. This study highlights the necessity to increase the awareness of TBE among physicians and perform active and systematic screening of TBEV antibodies among patients with viral meningitis and/or encephalitis.
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spelling pubmed-89516482022-03-26 Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis Banović, Pavle Díaz-Sánchez, Adrian Alberto Đurić, Selena Sević, Siniša Turkulov, Vesna Lendak, Dajana Mikić, Sandra Stefan Simin, Verica Mijatović, Dragana Bogdan, Ivana Potkonjak, Aleksandar Savić, Sara Obregón, Dasiel Cabezas-Cruz, Alejandro Pathogens Article The tick-borne encephalitis virus (TBEV) causes a life-threatening disease named Tick-borne encephalitis (TBE). The clinical symptoms associated with TBE range from non-specific to severe inflammation of the central nervous system and are very similar to the clinical presentation of other viral meningitis/encephalitis. In consequence, TBE is often misclassified by clinical physicians, mainly in the non-identified high-risk areas where none or only a few TBE cases have been reported. Considering this situation, we hypothesized that among persons from northern Serbia who recovered from viral meningitis or encephalitis, there would be evidence of TBEV infection. To test this hypothesis, in this observational study, we evaluated the seroreactivity against TBEV antigens in patients from northern Serbia who were hospitalized due to viral meningitis and/or viral encephalitis of unknown etiology. Three cases of seroreactivity to TBEV antigens were discovered among convalescent patients who recovered from viral meningitis and/or encephalitis and accepted to participate in the study (n = 15). The clinical and laboratory findings of these patients overlap with that of seronegative convalescent patients. Although TBE has been a notifiable disease in Serbia since 2004, there is no active TBE surveillance program for the serologic or molecular screening of TBEV infection in humans in the country. This study highlights the necessity to increase the awareness of TBE among physicians and perform active and systematic screening of TBEV antibodies among patients with viral meningitis and/or encephalitis. MDPI 2022-03-17 /pmc/articles/PMC8951648/ /pubmed/35335695 http://dx.doi.org/10.3390/pathogens11030371 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Banović, Pavle
Díaz-Sánchez, Adrian Alberto
Đurić, Selena
Sević, Siniša
Turkulov, Vesna
Lendak, Dajana
Mikić, Sandra Stefan
Simin, Verica
Mijatović, Dragana
Bogdan, Ivana
Potkonjak, Aleksandar
Savić, Sara
Obregón, Dasiel
Cabezas-Cruz, Alejandro
Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis
title Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis
title_full Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis
title_fullStr Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis
title_full_unstemmed Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis
title_short Unexpected TBEV Seropositivity in Serbian Patients Who Recovered from Viral Meningitis and Encephalitis
title_sort unexpected tbev seropositivity in serbian patients who recovered from viral meningitis and encephalitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951648/
https://www.ncbi.nlm.nih.gov/pubmed/35335695
http://dx.doi.org/10.3390/pathogens11030371
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