Production of Atosiban’s Key Intermediate Pentapeptide: Synthetic Approaches to the Development of a Peptide Synthesis with Less Racemization and Simplifier Purification Process

The key intermediate NH(2)-Ile-Thr(Bzl)-Asn-Cys(Bzl)-Pro-COOH of Atosiban was prepared from N-Boc-S-Bzl-cysteine by the stepwise lengthening of the chain according to the repetitive N,O-bis(trimethylsilyl)acetamide/N-hydroxysuccinimide ester (BSA/NHS) strategy. This synthetic route required no chrom...

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Detalles Bibliográficos
Autores principales: Ma, Chunying, Zheng, Yixuan, Liu, Jinwei, Li, Xiaobao, Feng, Wenhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951825/
https://www.ncbi.nlm.nih.gov/pubmed/35335281
http://dx.doi.org/10.3390/molecules27061920

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