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Plant Terpenoids as Hit Compounds against Trypanosomiasis
Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, respectively. These diseases were circumscribed to South American and African coun...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951850/ https://www.ncbi.nlm.nih.gov/pubmed/35337138 http://dx.doi.org/10.3390/ph15030340 |
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author | Durão, Raquel Ramalhete, Cátia Madureira, Ana Margarida Mendes, Eduarda Duarte, Noélia |
author_facet | Durão, Raquel Ramalhete, Cátia Madureira, Ana Margarida Mendes, Eduarda Duarte, Noélia |
author_sort | Durão, Raquel |
collection | PubMed |
description | Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, respectively. These diseases were circumscribed to South American and African countries in the past. However, human migration, military interventions, and climate changes have had an important effect on their worldwide propagation, particularly Chagas disease. Currently, the treatment of trypanosomiasis is not ideal, becoming a challenge in poor populations with limited resources. Exploring natural products from higher plants remains a valuable approach to find new hits and enlarge the pipeline of new drugs against protozoal human infections. This review covers the recent studies (2016–2021) on plant terpenoids, and their semi-synthetic derivatives, which have shown promising in vitro and in vivo activities against Trypanosoma parasites. |
format | Online Article Text |
id | pubmed-8951850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89518502022-03-26 Plant Terpenoids as Hit Compounds against Trypanosomiasis Durão, Raquel Ramalhete, Cátia Madureira, Ana Margarida Mendes, Eduarda Duarte, Noélia Pharmaceuticals (Basel) Review Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, respectively. These diseases were circumscribed to South American and African countries in the past. However, human migration, military interventions, and climate changes have had an important effect on their worldwide propagation, particularly Chagas disease. Currently, the treatment of trypanosomiasis is not ideal, becoming a challenge in poor populations with limited resources. Exploring natural products from higher plants remains a valuable approach to find new hits and enlarge the pipeline of new drugs against protozoal human infections. This review covers the recent studies (2016–2021) on plant terpenoids, and their semi-synthetic derivatives, which have shown promising in vitro and in vivo activities against Trypanosoma parasites. MDPI 2022-03-10 /pmc/articles/PMC8951850/ /pubmed/35337138 http://dx.doi.org/10.3390/ph15030340 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Durão, Raquel Ramalhete, Cátia Madureira, Ana Margarida Mendes, Eduarda Duarte, Noélia Plant Terpenoids as Hit Compounds against Trypanosomiasis |
title | Plant Terpenoids as Hit Compounds against Trypanosomiasis |
title_full | Plant Terpenoids as Hit Compounds against Trypanosomiasis |
title_fullStr | Plant Terpenoids as Hit Compounds against Trypanosomiasis |
title_full_unstemmed | Plant Terpenoids as Hit Compounds against Trypanosomiasis |
title_short | Plant Terpenoids as Hit Compounds against Trypanosomiasis |
title_sort | plant terpenoids as hit compounds against trypanosomiasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951850/ https://www.ncbi.nlm.nih.gov/pubmed/35337138 http://dx.doi.org/10.3390/ph15030340 |
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