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Plant Terpenoids as Hit Compounds against Trypanosomiasis

Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, respectively. These diseases were circumscribed to South American and African coun...

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Autores principales: Durão, Raquel, Ramalhete, Cátia, Madureira, Ana Margarida, Mendes, Eduarda, Duarte, Noélia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951850/
https://www.ncbi.nlm.nih.gov/pubmed/35337138
http://dx.doi.org/10.3390/ph15030340
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author Durão, Raquel
Ramalhete, Cátia
Madureira, Ana Margarida
Mendes, Eduarda
Duarte, Noélia
author_facet Durão, Raquel
Ramalhete, Cátia
Madureira, Ana Margarida
Mendes, Eduarda
Duarte, Noélia
author_sort Durão, Raquel
collection PubMed
description Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, respectively. These diseases were circumscribed to South American and African countries in the past. However, human migration, military interventions, and climate changes have had an important effect on their worldwide propagation, particularly Chagas disease. Currently, the treatment of trypanosomiasis is not ideal, becoming a challenge in poor populations with limited resources. Exploring natural products from higher plants remains a valuable approach to find new hits and enlarge the pipeline of new drugs against protozoal human infections. This review covers the recent studies (2016–2021) on plant terpenoids, and their semi-synthetic derivatives, which have shown promising in vitro and in vivo activities against Trypanosoma parasites.
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spelling pubmed-89518502022-03-26 Plant Terpenoids as Hit Compounds against Trypanosomiasis Durão, Raquel Ramalhete, Cátia Madureira, Ana Margarida Mendes, Eduarda Duarte, Noélia Pharmaceuticals (Basel) Review Human African trypanosomiasis (sleeping sickness) and American trypanosomiasis (Chagas disease) are vector-borne neglected tropical diseases, caused by the protozoan parasites Trypanosoma brucei and Trypanosoma cruzi, respectively. These diseases were circumscribed to South American and African countries in the past. However, human migration, military interventions, and climate changes have had an important effect on their worldwide propagation, particularly Chagas disease. Currently, the treatment of trypanosomiasis is not ideal, becoming a challenge in poor populations with limited resources. Exploring natural products from higher plants remains a valuable approach to find new hits and enlarge the pipeline of new drugs against protozoal human infections. This review covers the recent studies (2016–2021) on plant terpenoids, and their semi-synthetic derivatives, which have shown promising in vitro and in vivo activities against Trypanosoma parasites. MDPI 2022-03-10 /pmc/articles/PMC8951850/ /pubmed/35337138 http://dx.doi.org/10.3390/ph15030340 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Durão, Raquel
Ramalhete, Cátia
Madureira, Ana Margarida
Mendes, Eduarda
Duarte, Noélia
Plant Terpenoids as Hit Compounds against Trypanosomiasis
title Plant Terpenoids as Hit Compounds against Trypanosomiasis
title_full Plant Terpenoids as Hit Compounds against Trypanosomiasis
title_fullStr Plant Terpenoids as Hit Compounds against Trypanosomiasis
title_full_unstemmed Plant Terpenoids as Hit Compounds against Trypanosomiasis
title_short Plant Terpenoids as Hit Compounds against Trypanosomiasis
title_sort plant terpenoids as hit compounds against trypanosomiasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8951850/
https://www.ncbi.nlm.nih.gov/pubmed/35337138
http://dx.doi.org/10.3390/ph15030340
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