Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review

Metformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side eff...

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Detalles Bibliográficos
Autores principales: Ilias, Ioannis, Rizzo, Manfredi, Zabuliene, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952223/
https://www.ncbi.nlm.nih.gov/pubmed/35334606
http://dx.doi.org/10.3390/medicina58030430
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author Ilias, Ioannis
Rizzo, Manfredi
Zabuliene, Lina
author_facet Ilias, Ioannis
Rizzo, Manfredi
Zabuliene, Lina
author_sort Ilias, Ioannis
collection PubMed
description Metformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side effects. The incidence of cardiovascular events in women on MTF has been found to be lower to that of men on MTF. Despite some promising results with MTF regarding pregnancy rates in women with PCOS, the management of gestational diabetes, cancer prevention or adjunctive cancer treatment and COVID-19, most robust meta-analyses have yet to confirm such beneficial effects.
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spelling pubmed-89522232022-03-26 Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review Ilias, Ioannis Rizzo, Manfredi Zabuliene, Lina Medicina (Kaunas) Review Metformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side effects. The incidence of cardiovascular events in women on MTF has been found to be lower to that of men on MTF. Despite some promising results with MTF regarding pregnancy rates in women with PCOS, the management of gestational diabetes, cancer prevention or adjunctive cancer treatment and COVID-19, most robust meta-analyses have yet to confirm such beneficial effects. MDPI 2022-03-16 /pmc/articles/PMC8952223/ /pubmed/35334606 http://dx.doi.org/10.3390/medicina58030430 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ilias, Ioannis
Rizzo, Manfredi
Zabuliene, Lina
Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review
title Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review
title_full Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review
title_fullStr Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review
title_full_unstemmed Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review
title_short Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review
title_sort metformin: sex/gender differences in its uses and effects—narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952223/
https://www.ncbi.nlm.nih.gov/pubmed/35334606
http://dx.doi.org/10.3390/medicina58030430
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