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Reprogramming of arachidonate metabolism confers temozolomide resistance to glioblastoma through enhancing mitochondrial activity in fatty acid oxidation

BACKGROUND: Sp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement of resistance to temozolomide (TMZ). Particularly, the role of Sp1 in metabolic reprogramming for drug resistance remains unknown. METHODS: RNA-Seq and mass spectrometry were used to analyze gene expression an...

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Detalles Bibliográficos
Autores principales:	Tsai, Yu-Ting, Lo, Wei-Lun, Chen, Pin-Yuan, Ko, Chiung-Yuan, Chuang, Jian-Ying, Kao, Tzu-Jen, Yang, Wen-Bing, Chang, Kwang-Yu, Hung, Chia-Yang, Kikkawa, Ushio, Chang, Wen-Chang, Hsu, Tsung-I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952270/ https://www.ncbi.nlm.nih.gov/pubmed/35337344 http://dx.doi.org/10.1186/s12929-022-00804-3

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