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Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors

Breast cancer (BC) is the most common tumor in women worldwide with high mortality rates. Surgical methods followed by radio–chemotherapy are used to treat these tumors. Such treatment can lead to various side effects, including neurological complications. The development of a reliable biomarker to...

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Autores principales: Pospelova, Maria, Krasnikova, Varvara, Fionik, Olga, Alekseeva, Tatyana, Samochernykh, Konstantin, Ivanova, Nataliya, Trofimov, Nikita, Vavilova, Tatyana, Vasilieva, Elena, Topuzova, Mariya, Chaykovskaya, Alexandra, Makhanova, Albina, Bukkieva, Tatyana, Kayumova, Evgeniya, Combs, Stephanie, Shevtsov, Maxim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952280/
https://www.ncbi.nlm.nih.gov/pubmed/35366289
http://dx.doi.org/10.3390/pathophysiology29010006
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author Pospelova, Maria
Krasnikova, Varvara
Fionik, Olga
Alekseeva, Tatyana
Samochernykh, Konstantin
Ivanova, Nataliya
Trofimov, Nikita
Vavilova, Tatyana
Vasilieva, Elena
Topuzova, Mariya
Chaykovskaya, Alexandra
Makhanova, Albina
Bukkieva, Tatyana
Kayumova, Evgeniya
Combs, Stephanie
Shevtsov, Maxim
author_facet Pospelova, Maria
Krasnikova, Varvara
Fionik, Olga
Alekseeva, Tatyana
Samochernykh, Konstantin
Ivanova, Nataliya
Trofimov, Nikita
Vavilova, Tatyana
Vasilieva, Elena
Topuzova, Mariya
Chaykovskaya, Alexandra
Makhanova, Albina
Bukkieva, Tatyana
Kayumova, Evgeniya
Combs, Stephanie
Shevtsov, Maxim
author_sort Pospelova, Maria
collection PubMed
description Breast cancer (BC) is the most common tumor in women worldwide with high mortality rates. Surgical methods followed by radio–chemotherapy are used to treat these tumors. Such treatment can lead to various side effects, including neurological complications. The development of a reliable biomarker to predict the onset of CNS complications could improve clinical outcomes. In the current study, ICAM-1 and PECAM-1 serum levels were measured as potential biomarkers in 45 female patients in a long-term follow-up period after breast cancer treatment, and compared to 25 age-matched female healthy volunteers. Serum levels of both biomarkers, ICAM-1 and PECAM-1 were significantly higher in patients after breast cancer treatment and could be associated with cognitive dysfunction, depression, and vestibulocerebellar ataxia. In conclusion, our results provide a first hint that elevated serum levels of ICAM-1 and PECAM-1 could serve as early predictive biomarkers in breast cancer survivors that might help to improve the management of these patients.
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spelling pubmed-89522802022-03-26 Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors Pospelova, Maria Krasnikova, Varvara Fionik, Olga Alekseeva, Tatyana Samochernykh, Konstantin Ivanova, Nataliya Trofimov, Nikita Vavilova, Tatyana Vasilieva, Elena Topuzova, Mariya Chaykovskaya, Alexandra Makhanova, Albina Bukkieva, Tatyana Kayumova, Evgeniya Combs, Stephanie Shevtsov, Maxim Pathophysiology Article Breast cancer (BC) is the most common tumor in women worldwide with high mortality rates. Surgical methods followed by radio–chemotherapy are used to treat these tumors. Such treatment can lead to various side effects, including neurological complications. The development of a reliable biomarker to predict the onset of CNS complications could improve clinical outcomes. In the current study, ICAM-1 and PECAM-1 serum levels were measured as potential biomarkers in 45 female patients in a long-term follow-up period after breast cancer treatment, and compared to 25 age-matched female healthy volunteers. Serum levels of both biomarkers, ICAM-1 and PECAM-1 were significantly higher in patients after breast cancer treatment and could be associated with cognitive dysfunction, depression, and vestibulocerebellar ataxia. In conclusion, our results provide a first hint that elevated serum levels of ICAM-1 and PECAM-1 could serve as early predictive biomarkers in breast cancer survivors that might help to improve the management of these patients. MDPI 2022-02-16 /pmc/articles/PMC8952280/ /pubmed/35366289 http://dx.doi.org/10.3390/pathophysiology29010006 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pospelova, Maria
Krasnikova, Varvara
Fionik, Olga
Alekseeva, Tatyana
Samochernykh, Konstantin
Ivanova, Nataliya
Trofimov, Nikita
Vavilova, Tatyana
Vasilieva, Elena
Topuzova, Mariya
Chaykovskaya, Alexandra
Makhanova, Albina
Bukkieva, Tatyana
Kayumova, Evgeniya
Combs, Stephanie
Shevtsov, Maxim
Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors
title Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors
title_full Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors
title_fullStr Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors
title_full_unstemmed Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors
title_short Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors
title_sort adhesion molecules icam-1 and pecam-1 as potential biomarkers of central nervous system damage in women breast cancer survivors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952280/
https://www.ncbi.nlm.nih.gov/pubmed/35366289
http://dx.doi.org/10.3390/pathophysiology29010006
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