Cargando…
Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors
Breast cancer (BC) is the most common tumor in women worldwide with high mortality rates. Surgical methods followed by radio–chemotherapy are used to treat these tumors. Such treatment can lead to various side effects, including neurological complications. The development of a reliable biomarker to...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952280/ https://www.ncbi.nlm.nih.gov/pubmed/35366289 http://dx.doi.org/10.3390/pathophysiology29010006 |
_version_ | 1784675576110383104 |
---|---|
author | Pospelova, Maria Krasnikova, Varvara Fionik, Olga Alekseeva, Tatyana Samochernykh, Konstantin Ivanova, Nataliya Trofimov, Nikita Vavilova, Tatyana Vasilieva, Elena Topuzova, Mariya Chaykovskaya, Alexandra Makhanova, Albina Bukkieva, Tatyana Kayumova, Evgeniya Combs, Stephanie Shevtsov, Maxim |
author_facet | Pospelova, Maria Krasnikova, Varvara Fionik, Olga Alekseeva, Tatyana Samochernykh, Konstantin Ivanova, Nataliya Trofimov, Nikita Vavilova, Tatyana Vasilieva, Elena Topuzova, Mariya Chaykovskaya, Alexandra Makhanova, Albina Bukkieva, Tatyana Kayumova, Evgeniya Combs, Stephanie Shevtsov, Maxim |
author_sort | Pospelova, Maria |
collection | PubMed |
description | Breast cancer (BC) is the most common tumor in women worldwide with high mortality rates. Surgical methods followed by radio–chemotherapy are used to treat these tumors. Such treatment can lead to various side effects, including neurological complications. The development of a reliable biomarker to predict the onset of CNS complications could improve clinical outcomes. In the current study, ICAM-1 and PECAM-1 serum levels were measured as potential biomarkers in 45 female patients in a long-term follow-up period after breast cancer treatment, and compared to 25 age-matched female healthy volunteers. Serum levels of both biomarkers, ICAM-1 and PECAM-1 were significantly higher in patients after breast cancer treatment and could be associated with cognitive dysfunction, depression, and vestibulocerebellar ataxia. In conclusion, our results provide a first hint that elevated serum levels of ICAM-1 and PECAM-1 could serve as early predictive biomarkers in breast cancer survivors that might help to improve the management of these patients. |
format | Online Article Text |
id | pubmed-8952280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89522802022-03-26 Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors Pospelova, Maria Krasnikova, Varvara Fionik, Olga Alekseeva, Tatyana Samochernykh, Konstantin Ivanova, Nataliya Trofimov, Nikita Vavilova, Tatyana Vasilieva, Elena Topuzova, Mariya Chaykovskaya, Alexandra Makhanova, Albina Bukkieva, Tatyana Kayumova, Evgeniya Combs, Stephanie Shevtsov, Maxim Pathophysiology Article Breast cancer (BC) is the most common tumor in women worldwide with high mortality rates. Surgical methods followed by radio–chemotherapy are used to treat these tumors. Such treatment can lead to various side effects, including neurological complications. The development of a reliable biomarker to predict the onset of CNS complications could improve clinical outcomes. In the current study, ICAM-1 and PECAM-1 serum levels were measured as potential biomarkers in 45 female patients in a long-term follow-up period after breast cancer treatment, and compared to 25 age-matched female healthy volunteers. Serum levels of both biomarkers, ICAM-1 and PECAM-1 were significantly higher in patients after breast cancer treatment and could be associated with cognitive dysfunction, depression, and vestibulocerebellar ataxia. In conclusion, our results provide a first hint that elevated serum levels of ICAM-1 and PECAM-1 could serve as early predictive biomarkers in breast cancer survivors that might help to improve the management of these patients. MDPI 2022-02-16 /pmc/articles/PMC8952280/ /pubmed/35366289 http://dx.doi.org/10.3390/pathophysiology29010006 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pospelova, Maria Krasnikova, Varvara Fionik, Olga Alekseeva, Tatyana Samochernykh, Konstantin Ivanova, Nataliya Trofimov, Nikita Vavilova, Tatyana Vasilieva, Elena Topuzova, Mariya Chaykovskaya, Alexandra Makhanova, Albina Bukkieva, Tatyana Kayumova, Evgeniya Combs, Stephanie Shevtsov, Maxim Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors |
title | Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors |
title_full | Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors |
title_fullStr | Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors |
title_full_unstemmed | Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors |
title_short | Adhesion Molecules ICAM-1 and PECAM-1 as Potential Biomarkers of Central Nervous System Damage in Women Breast Cancer Survivors |
title_sort | adhesion molecules icam-1 and pecam-1 as potential biomarkers of central nervous system damage in women breast cancer survivors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952280/ https://www.ncbi.nlm.nih.gov/pubmed/35366289 http://dx.doi.org/10.3390/pathophysiology29010006 |
work_keys_str_mv | AT pospelovamaria adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT krasnikovavarvara adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT fionikolga adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT alekseevatatyana adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT samochernykhkonstantin adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT ivanovanataliya adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT trofimovnikita adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT vavilovatatyana adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT vasilievaelena adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT topuzovamariya adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT chaykovskayaalexandra adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT makhanovaalbina adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT bukkievatatyana adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT kayumovaevgeniya adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT combsstephanie adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors AT shevtsovmaxim adhesionmoleculesicam1andpecam1aspotentialbiomarkersofcentralnervoussystemdamageinwomenbreastcancersurvivors |