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Neuroimaging Findings in Pediatric Patients with Thalassemia Major

Background: Cranial magnetic resonance imaging (MRI) studies about iron accumulation in children with thalassemia major are quite limited. Aim: This study aimed to detect neurological findings with cranial MRIs in the pediatric patients with thalassemia major who did not develop any neurological com...

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Autores principales: Akbaş, Yılmaz, Aydın, Sultan, Tunçer, Gökçen Öz, Köker, Alper, Çoban, Yasemin, Oktay, Gönül, Yeral, Hakan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952535/
https://www.ncbi.nlm.nih.gov/pubmed/35323180
http://dx.doi.org/10.3390/hematolrep14010009
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author Akbaş, Yılmaz
Aydın, Sultan
Tunçer, Gökçen Öz
Köker, Alper
Çoban, Yasemin
Oktay, Gönül
Yeral, Hakan
author_facet Akbaş, Yılmaz
Aydın, Sultan
Tunçer, Gökçen Öz
Köker, Alper
Çoban, Yasemin
Oktay, Gönül
Yeral, Hakan
author_sort Akbaş, Yılmaz
collection PubMed
description Background: Cranial magnetic resonance imaging (MRI) studies about iron accumulation in children with thalassemia major are quite limited. Aim: This study aimed to detect neurological findings with cranial MRIs in the pediatric patients with thalassemia major who did not develop any neurological complications. Materials and Methods: Pediatric patients with thalassemia major who followed in the Pediatric Hematology Unit between 1 July 2017 and 1 January 2019 were included in the study. The patients underwent cranial MRI scans. Results: A total of 30 patients were included. The median age was 15 (range from 4–18) years old. We found that 7 patients had a splenectomy and 19 of the remaining 23 patients had splenomegaly. In addition, 13 of the patients had hepatomegaly, 10 had skeletal deformities, and 17 had growth retardation. The mean ferritin level was 3772.3 ± 2524.8. We detected various pathologies on cranial MRI images of 10 (33.3%) patients. In 3 of these patients, millimeter-sized ischemia-compatible lesions were found in the cerebral white matter, which did not fit any arterial area, and 5 patients had hyperintense lesions in the basal ganglia. Conclusion: Our study is valuable since 1/3 of our pediatric patients with thalassemia major were detected with intracranial pathology.
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spelling pubmed-89525352022-03-26 Neuroimaging Findings in Pediatric Patients with Thalassemia Major Akbaş, Yılmaz Aydın, Sultan Tunçer, Gökçen Öz Köker, Alper Çoban, Yasemin Oktay, Gönül Yeral, Hakan Hematol Rep Article Background: Cranial magnetic resonance imaging (MRI) studies about iron accumulation in children with thalassemia major are quite limited. Aim: This study aimed to detect neurological findings with cranial MRIs in the pediatric patients with thalassemia major who did not develop any neurological complications. Materials and Methods: Pediatric patients with thalassemia major who followed in the Pediatric Hematology Unit between 1 July 2017 and 1 January 2019 were included in the study. The patients underwent cranial MRI scans. Results: A total of 30 patients were included. The median age was 15 (range from 4–18) years old. We found that 7 patients had a splenectomy and 19 of the remaining 23 patients had splenomegaly. In addition, 13 of the patients had hepatomegaly, 10 had skeletal deformities, and 17 had growth retardation. The mean ferritin level was 3772.3 ± 2524.8. We detected various pathologies on cranial MRI images of 10 (33.3%) patients. In 3 of these patients, millimeter-sized ischemia-compatible lesions were found in the cerebral white matter, which did not fit any arterial area, and 5 patients had hyperintense lesions in the basal ganglia. Conclusion: Our study is valuable since 1/3 of our pediatric patients with thalassemia major were detected with intracranial pathology. MDPI 2022-03-21 /pmc/articles/PMC8952535/ /pubmed/35323180 http://dx.doi.org/10.3390/hematolrep14010009 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Akbaş, Yılmaz
Aydın, Sultan
Tunçer, Gökçen Öz
Köker, Alper
Çoban, Yasemin
Oktay, Gönül
Yeral, Hakan
Neuroimaging Findings in Pediatric Patients with Thalassemia Major
title Neuroimaging Findings in Pediatric Patients with Thalassemia Major
title_full Neuroimaging Findings in Pediatric Patients with Thalassemia Major
title_fullStr Neuroimaging Findings in Pediatric Patients with Thalassemia Major
title_full_unstemmed Neuroimaging Findings in Pediatric Patients with Thalassemia Major
title_short Neuroimaging Findings in Pediatric Patients with Thalassemia Major
title_sort neuroimaging findings in pediatric patients with thalassemia major
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952535/
https://www.ncbi.nlm.nih.gov/pubmed/35323180
http://dx.doi.org/10.3390/hematolrep14010009
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