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Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells

Corynebacterium diphtheriae, the etiological agent of diphtheria, is a re-emerging pathogen, responsible for several thousand deaths per year. In addition to diphtheria, systemic infections, often by non-toxigenic strains, are increasingly observed. This indicates that besides the well-studied and h...

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Autores principales: Ott, Lisa, Möller, Jens, Burkovski, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952647/
https://www.ncbi.nlm.nih.gov/pubmed/35328715
http://dx.doi.org/10.3390/ijms23063298
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author Ott, Lisa
Möller, Jens
Burkovski, Andreas
author_facet Ott, Lisa
Möller, Jens
Burkovski, Andreas
author_sort Ott, Lisa
collection PubMed
description Corynebacterium diphtheriae, the etiological agent of diphtheria, is a re-emerging pathogen, responsible for several thousand deaths per year. In addition to diphtheria, systemic infections, often by non-toxigenic strains, are increasingly observed. This indicates that besides the well-studied and highly potent diphtheria toxin, various other virulence factors may influence the progression of the infection. This review focuses on the known components of C. diphtheriae responsible for adhesion, invasion, inflammation, and cell death, as well as on the cellular signaling pathways activated upon infection.
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spelling pubmed-89526472022-03-26 Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells Ott, Lisa Möller, Jens Burkovski, Andreas Int J Mol Sci Review Corynebacterium diphtheriae, the etiological agent of diphtheria, is a re-emerging pathogen, responsible for several thousand deaths per year. In addition to diphtheria, systemic infections, often by non-toxigenic strains, are increasingly observed. This indicates that besides the well-studied and highly potent diphtheria toxin, various other virulence factors may influence the progression of the infection. This review focuses on the known components of C. diphtheriae responsible for adhesion, invasion, inflammation, and cell death, as well as on the cellular signaling pathways activated upon infection. MDPI 2022-03-18 /pmc/articles/PMC8952647/ /pubmed/35328715 http://dx.doi.org/10.3390/ijms23063298 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ott, Lisa
Möller, Jens
Burkovski, Andreas
Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells
title Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells
title_full Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells
title_fullStr Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells
title_full_unstemmed Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells
title_short Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells
title_sort interactions between the re-emerging pathogen corynebacterium diphtheriae and host cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952647/
https://www.ncbi.nlm.nih.gov/pubmed/35328715
http://dx.doi.org/10.3390/ijms23063298
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