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Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells
Corynebacterium diphtheriae, the etiological agent of diphtheria, is a re-emerging pathogen, responsible for several thousand deaths per year. In addition to diphtheria, systemic infections, often by non-toxigenic strains, are increasingly observed. This indicates that besides the well-studied and h...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952647/ https://www.ncbi.nlm.nih.gov/pubmed/35328715 http://dx.doi.org/10.3390/ijms23063298 |
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author | Ott, Lisa Möller, Jens Burkovski, Andreas |
author_facet | Ott, Lisa Möller, Jens Burkovski, Andreas |
author_sort | Ott, Lisa |
collection | PubMed |
description | Corynebacterium diphtheriae, the etiological agent of diphtheria, is a re-emerging pathogen, responsible for several thousand deaths per year. In addition to diphtheria, systemic infections, often by non-toxigenic strains, are increasingly observed. This indicates that besides the well-studied and highly potent diphtheria toxin, various other virulence factors may influence the progression of the infection. This review focuses on the known components of C. diphtheriae responsible for adhesion, invasion, inflammation, and cell death, as well as on the cellular signaling pathways activated upon infection. |
format | Online Article Text |
id | pubmed-8952647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89526472022-03-26 Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells Ott, Lisa Möller, Jens Burkovski, Andreas Int J Mol Sci Review Corynebacterium diphtheriae, the etiological agent of diphtheria, is a re-emerging pathogen, responsible for several thousand deaths per year. In addition to diphtheria, systemic infections, often by non-toxigenic strains, are increasingly observed. This indicates that besides the well-studied and highly potent diphtheria toxin, various other virulence factors may influence the progression of the infection. This review focuses on the known components of C. diphtheriae responsible for adhesion, invasion, inflammation, and cell death, as well as on the cellular signaling pathways activated upon infection. MDPI 2022-03-18 /pmc/articles/PMC8952647/ /pubmed/35328715 http://dx.doi.org/10.3390/ijms23063298 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ott, Lisa Möller, Jens Burkovski, Andreas Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells |
title | Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells |
title_full | Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells |
title_fullStr | Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells |
title_full_unstemmed | Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells |
title_short | Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells |
title_sort | interactions between the re-emerging pathogen corynebacterium diphtheriae and host cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952647/ https://www.ncbi.nlm.nih.gov/pubmed/35328715 http://dx.doi.org/10.3390/ijms23063298 |
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