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The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia

In an effort to standardize practice, the European Confederation of Medical Mycology (ECMM) developed the European Confederation of Medical Mycology Quality of Clinical Candidaemia Management (EQUAL) Candida score. This study investigated the utility of the EQUAL Candida score in predicting mortalit...

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Autores principales: El Zakhem, Aline, El Eid, Rozana, Istambouli, Rachid, Tamim, Hani, Kanj, Souha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952788/
https://www.ncbi.nlm.nih.gov/pubmed/35330240
http://dx.doi.org/10.3390/jof8030238
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author El Zakhem, Aline
El Eid, Rozana
Istambouli, Rachid
Tamim, Hani
Kanj, Souha S.
author_facet El Zakhem, Aline
El Eid, Rozana
Istambouli, Rachid
Tamim, Hani
Kanj, Souha S.
author_sort El Zakhem, Aline
collection PubMed
description In an effort to standardize practice, the European Confederation of Medical Mycology (ECMM) developed the European Confederation of Medical Mycology Quality of Clinical Candidaemia Management (EQUAL) Candida score. This study investigated the utility of the EQUAL Candida score in predicting mortality in patients with candidemia admitted between January 2004 and July 2019. A total of 142 cases were included in the study, and 43.6% died within 30 days of candidemia diagnosis. There were no significant differences between survivors and non-survivors in terms of comorbidities predisposing to candidemia, except for malignancy (p = 0.021). The overall mean EQUAL score was 11.5 in the total population and 11.8 ± 3.82 and 11.03 ± 4.59 in survivors and non-survivors, respectively. When patients with a central venous catheter (CVC) were considered alone, survivors were found to have significantly higher scores than non-survivors (13.1 ± 3.19 vs. 11.3 ± 4.77, p = 0.025). When assessing components of the EQUAL Score separately, only candida speciation (p = 0.013), susceptibility testing (p = 0.012) and echocardiography results (p = 0.012) were significantly associated with a lower case-fatality rate. A higher EQUAL Candida score was able to predict a lower case-fatality rate in patients with a CVC.
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spelling pubmed-89527882022-03-26 The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia El Zakhem, Aline El Eid, Rozana Istambouli, Rachid Tamim, Hani Kanj, Souha S. J Fungi (Basel) Article In an effort to standardize practice, the European Confederation of Medical Mycology (ECMM) developed the European Confederation of Medical Mycology Quality of Clinical Candidaemia Management (EQUAL) Candida score. This study investigated the utility of the EQUAL Candida score in predicting mortality in patients with candidemia admitted between January 2004 and July 2019. A total of 142 cases were included in the study, and 43.6% died within 30 days of candidemia diagnosis. There were no significant differences between survivors and non-survivors in terms of comorbidities predisposing to candidemia, except for malignancy (p = 0.021). The overall mean EQUAL score was 11.5 in the total population and 11.8 ± 3.82 and 11.03 ± 4.59 in survivors and non-survivors, respectively. When patients with a central venous catheter (CVC) were considered alone, survivors were found to have significantly higher scores than non-survivors (13.1 ± 3.19 vs. 11.3 ± 4.77, p = 0.025). When assessing components of the EQUAL Score separately, only candida speciation (p = 0.013), susceptibility testing (p = 0.012) and echocardiography results (p = 0.012) were significantly associated with a lower case-fatality rate. A higher EQUAL Candida score was able to predict a lower case-fatality rate in patients with a CVC. MDPI 2022-02-27 /pmc/articles/PMC8952788/ /pubmed/35330240 http://dx.doi.org/10.3390/jof8030238 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
El Zakhem, Aline
El Eid, Rozana
Istambouli, Rachid
Tamim, Hani
Kanj, Souha S.
The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia
title The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia
title_full The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia
title_fullStr The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia
title_full_unstemmed The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia
title_short The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia
title_sort utility of equal candida score in predicting mortality in patients with candidemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952788/
https://www.ncbi.nlm.nih.gov/pubmed/35330240
http://dx.doi.org/10.3390/jof8030238
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