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The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia
In an effort to standardize practice, the European Confederation of Medical Mycology (ECMM) developed the European Confederation of Medical Mycology Quality of Clinical Candidaemia Management (EQUAL) Candida score. This study investigated the utility of the EQUAL Candida score in predicting mortalit...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952788/ https://www.ncbi.nlm.nih.gov/pubmed/35330240 http://dx.doi.org/10.3390/jof8030238 |
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author | El Zakhem, Aline El Eid, Rozana Istambouli, Rachid Tamim, Hani Kanj, Souha S. |
author_facet | El Zakhem, Aline El Eid, Rozana Istambouli, Rachid Tamim, Hani Kanj, Souha S. |
author_sort | El Zakhem, Aline |
collection | PubMed |
description | In an effort to standardize practice, the European Confederation of Medical Mycology (ECMM) developed the European Confederation of Medical Mycology Quality of Clinical Candidaemia Management (EQUAL) Candida score. This study investigated the utility of the EQUAL Candida score in predicting mortality in patients with candidemia admitted between January 2004 and July 2019. A total of 142 cases were included in the study, and 43.6% died within 30 days of candidemia diagnosis. There were no significant differences between survivors and non-survivors in terms of comorbidities predisposing to candidemia, except for malignancy (p = 0.021). The overall mean EQUAL score was 11.5 in the total population and 11.8 ± 3.82 and 11.03 ± 4.59 in survivors and non-survivors, respectively. When patients with a central venous catheter (CVC) were considered alone, survivors were found to have significantly higher scores than non-survivors (13.1 ± 3.19 vs. 11.3 ± 4.77, p = 0.025). When assessing components of the EQUAL Score separately, only candida speciation (p = 0.013), susceptibility testing (p = 0.012) and echocardiography results (p = 0.012) were significantly associated with a lower case-fatality rate. A higher EQUAL Candida score was able to predict a lower case-fatality rate in patients with a CVC. |
format | Online Article Text |
id | pubmed-8952788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89527882022-03-26 The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia El Zakhem, Aline El Eid, Rozana Istambouli, Rachid Tamim, Hani Kanj, Souha S. J Fungi (Basel) Article In an effort to standardize practice, the European Confederation of Medical Mycology (ECMM) developed the European Confederation of Medical Mycology Quality of Clinical Candidaemia Management (EQUAL) Candida score. This study investigated the utility of the EQUAL Candida score in predicting mortality in patients with candidemia admitted between January 2004 and July 2019. A total of 142 cases were included in the study, and 43.6% died within 30 days of candidemia diagnosis. There were no significant differences between survivors and non-survivors in terms of comorbidities predisposing to candidemia, except for malignancy (p = 0.021). The overall mean EQUAL score was 11.5 in the total population and 11.8 ± 3.82 and 11.03 ± 4.59 in survivors and non-survivors, respectively. When patients with a central venous catheter (CVC) were considered alone, survivors were found to have significantly higher scores than non-survivors (13.1 ± 3.19 vs. 11.3 ± 4.77, p = 0.025). When assessing components of the EQUAL Score separately, only candida speciation (p = 0.013), susceptibility testing (p = 0.012) and echocardiography results (p = 0.012) were significantly associated with a lower case-fatality rate. A higher EQUAL Candida score was able to predict a lower case-fatality rate in patients with a CVC. MDPI 2022-02-27 /pmc/articles/PMC8952788/ /pubmed/35330240 http://dx.doi.org/10.3390/jof8030238 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article El Zakhem, Aline El Eid, Rozana Istambouli, Rachid Tamim, Hani Kanj, Souha S. The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia |
title | The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia |
title_full | The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia |
title_fullStr | The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia |
title_full_unstemmed | The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia |
title_short | The Utility of EQUAL Candida Score in Predicting Mortality in Patients with Candidemia |
title_sort | utility of equal candida score in predicting mortality in patients with candidemia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952788/ https://www.ncbi.nlm.nih.gov/pubmed/35330240 http://dx.doi.org/10.3390/jof8030238 |
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