Cargando…

Successive Pandemic Waves with Different Virulent Strains and the Effects of Vaccination for SARS-CoV-2

One hundred years after the flu pandemic of 1918, the world faces an outbreak of a new severe acute respiratory syndrome, caused by a novel coronavirus. With a high transmissibility, the pandemic has spread worldwide, creating a scenario of devastation in many countries. By the middle of 2021, about...

Descripción completa

Detalles Bibliográficos
Autores principales: Castro e Silva, Alcides, Bernardes, Américo Tristão, Barbosa, Eduardo Augusto Gonçalves, Chagas, Igor Aparecido Santana das, Dáttilo, Wesley, Reis, Alexandre Barbosa, Ribeiro, Sérvio Pontes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952817/
https://www.ncbi.nlm.nih.gov/pubmed/35334975
http://dx.doi.org/10.3390/vaccines10030343
_version_ 1784675710769561600
author Castro e Silva, Alcides
Bernardes, Américo Tristão
Barbosa, Eduardo Augusto Gonçalves
Chagas, Igor Aparecido Santana das
Dáttilo, Wesley
Reis, Alexandre Barbosa
Ribeiro, Sérvio Pontes
author_facet Castro e Silva, Alcides
Bernardes, Américo Tristão
Barbosa, Eduardo Augusto Gonçalves
Chagas, Igor Aparecido Santana das
Dáttilo, Wesley
Reis, Alexandre Barbosa
Ribeiro, Sérvio Pontes
author_sort Castro e Silva, Alcides
collection PubMed
description One hundred years after the flu pandemic of 1918, the world faces an outbreak of a new severe acute respiratory syndrome, caused by a novel coronavirus. With a high transmissibility, the pandemic has spread worldwide, creating a scenario of devastation in many countries. By the middle of 2021, about 3% of the world population had been infected and more than 4 million people had died. Different from the H1N1 pandemic, which had a deadly wave and ceased, the new disease is maintained by successive waves, mainly produced by new virus variants and the small number of vaccinated people. In the present work, we create a version of the SIR model using the spatial localization of persons, their movements, and considering social isolation probabilities. We discuss the effects of virus variants, and the role of vaccination rate in the pandemic dynamics. We show that, unless a global vaccination is implemented, we will have continuous waves of infections.
format Online
Article
Text
id pubmed-8952817
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89528172022-03-26 Successive Pandemic Waves with Different Virulent Strains and the Effects of Vaccination for SARS-CoV-2 Castro e Silva, Alcides Bernardes, Américo Tristão Barbosa, Eduardo Augusto Gonçalves Chagas, Igor Aparecido Santana das Dáttilo, Wesley Reis, Alexandre Barbosa Ribeiro, Sérvio Pontes Vaccines (Basel) Article One hundred years after the flu pandemic of 1918, the world faces an outbreak of a new severe acute respiratory syndrome, caused by a novel coronavirus. With a high transmissibility, the pandemic has spread worldwide, creating a scenario of devastation in many countries. By the middle of 2021, about 3% of the world population had been infected and more than 4 million people had died. Different from the H1N1 pandemic, which had a deadly wave and ceased, the new disease is maintained by successive waves, mainly produced by new virus variants and the small number of vaccinated people. In the present work, we create a version of the SIR model using the spatial localization of persons, their movements, and considering social isolation probabilities. We discuss the effects of virus variants, and the role of vaccination rate in the pandemic dynamics. We show that, unless a global vaccination is implemented, we will have continuous waves of infections. MDPI 2022-02-22 /pmc/articles/PMC8952817/ /pubmed/35334975 http://dx.doi.org/10.3390/vaccines10030343 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Castro e Silva, Alcides
Bernardes, Américo Tristão
Barbosa, Eduardo Augusto Gonçalves
Chagas, Igor Aparecido Santana das
Dáttilo, Wesley
Reis, Alexandre Barbosa
Ribeiro, Sérvio Pontes
Successive Pandemic Waves with Different Virulent Strains and the Effects of Vaccination for SARS-CoV-2
title Successive Pandemic Waves with Different Virulent Strains and the Effects of Vaccination for SARS-CoV-2
title_full Successive Pandemic Waves with Different Virulent Strains and the Effects of Vaccination for SARS-CoV-2
title_fullStr Successive Pandemic Waves with Different Virulent Strains and the Effects of Vaccination for SARS-CoV-2
title_full_unstemmed Successive Pandemic Waves with Different Virulent Strains and the Effects of Vaccination for SARS-CoV-2
title_short Successive Pandemic Waves with Different Virulent Strains and the Effects of Vaccination for SARS-CoV-2
title_sort successive pandemic waves with different virulent strains and the effects of vaccination for sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8952817/
https://www.ncbi.nlm.nih.gov/pubmed/35334975
http://dx.doi.org/10.3390/vaccines10030343
work_keys_str_mv AT castroesilvaalcides successivepandemicwaveswithdifferentvirulentstrainsandtheeffectsofvaccinationforsarscov2
AT bernardesamericotristao successivepandemicwaveswithdifferentvirulentstrainsandtheeffectsofvaccinationforsarscov2
AT barbosaeduardoaugustogoncalves successivepandemicwaveswithdifferentvirulentstrainsandtheeffectsofvaccinationforsarscov2
AT chagasigoraparecidosantanadas successivepandemicwaveswithdifferentvirulentstrainsandtheeffectsofvaccinationforsarscov2
AT dattilowesley successivepandemicwaveswithdifferentvirulentstrainsandtheeffectsofvaccinationforsarscov2
AT reisalexandrebarbosa successivepandemicwaveswithdifferentvirulentstrainsandtheeffectsofvaccinationforsarscov2
AT ribeiroserviopontes successivepandemicwaveswithdifferentvirulentstrainsandtheeffectsofvaccinationforsarscov2