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Context dependent isoform specific PI3K inhibition confers drug resistance in hepatocellular carcinoma cells

BACKGROUND: Targeted therapies for Primary liver cancer (HCC) is limited to the multi-kinase inhibitors, and not fully effective due to the resistance to these agents because of the heterogeneous molecular nature of HCC developed during chronic liver disease stages and cirrhosis. Although combinator...

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Detalles Bibliográficos
Autores principales:	Narci, Kubra, Kahraman, Deniz Cansen, Koyas, Altay, Ersahin, Tulin, Tuncbag, Nurcan, Atalay, Rengul Cetin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953069/ https://www.ncbi.nlm.nih.gov/pubmed/35331184 http://dx.doi.org/10.1186/s12885-022-09357-y

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