Cargando…

Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms

Kaposi’s sarcoma herpesvirus (KSHV) is associated with a significant disease burden, in particular in Sub-Sahara Africa. A KSHV vaccine would be highly desirable, but the mechanisms underlying neutralizing antibody responses against KSHV remain largely unexplored. The complex made of glycoproteins H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fricke, Thomas, Großkopf, Anna K., Ensser, Armin, Backovic, Marija, Hahn, Alexander S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953146/ https://www.ncbi.nlm.nih.gov/pubmed/35336948 http://dx.doi.org/10.3390/v14030541

Ejemplares similares

The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) gH/gL Complex Is the Predominant Neutralizing Antigenic Determinant in KSHV-Infected Individuals
por: Mortazavi, Yasaman, et al.
Publicado: (2020)

A conserved Eph family receptor-binding motif on the gH/gL complex of Kaposi’s sarcoma-associated herpesvirus and rhesus monkey rhadinovirus
por: Großkopf, Anna K., et al.
Publicado: (2018)

The Murid Herpesvirus-4 gH/gL Binds to Glycosaminoglycans
por: Gillet, Laurent, et al.
Publicado: (2008)

A Neutralizing Anti-gH/gL Monoclonal Antibody Is Protective in the Guinea Pig Model of Congenital CMV Infection
por: Auerbach, Marcy R., et al.
Publicado: (2014)

Fibroblast, Epithelial and Endothelial Cell-Derived Human Cytomegalovirus Strains Display Distinct Neutralizing Antibody Responses and Varying Levels of gH/gL Complexes
por: Fornara, Chiara, et al.
Publicado: (2023)

In Vitro Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry
por: Vallbracht, Melina, et al.
Publicado: (2021)

Crystal structure of the conserved herpesvirus fusion regulator complex gH–gL
por: Chowdary, Tirumala K., et al.
Publicado: (2010)

Human Cytomegalovirus Vaccine Based on the Envelope gH/gL Pentamer Complex
por: Wussow, Felix, et al.
Publicado: (2014)

Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies
por: Ciferri, Claudio, et al.
Publicado: (2015)

BALB/c mice immunized with a combination of virus-like particles incorporating Kaposi sarcoma-associated herpesvirus (KSHV) envelope glycoproteins gpK8.1, gB, and gH/gL induced comparable serum neutralizing antibody activity to UV-inactivated KSHV
por: Barasa, Anne K, et al.
Publicado: (2017)

Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex
por: Ha, Sha, et al.
Publicado: (2017)

Potent Bispecific Neutralizing Antibody Targeting Glycoprotein B and the gH/gL/pUL128/130/131 Complex of Human Cytomegalovirus
por: Su, Hang, et al.
Publicado: (2021)

The Murid Herpesvirus-4 gL Regulates an Entry-Associated Conformation Change in gH
por: Gillet, Laurent, et al.
Publicado: (2008)

Well Put Together—A Guide to Accessorizing with the Herpesvirus gH/gL Complexes
por: Gonzalez-Del Pino, Gonzalo L., et al.
Publicado: (2022)

Immunization of Rabbits with Recombinant Human Cytomegalovirus Trimeric versus Monomeric gH/gL Protein Elicits Markedly Higher Titers of Antibody and Neutralization Activity
por: Cui, Xinle, et al.
Publicado: (2019)

Correction: The Murid Herpesvirus-4 gL Regulates an Entry-Associated Conformation Change in gH
por: Gillet, Laurent, et al.
Publicado: (2008)

Distribution of the CMV glycoprotein gH/gL/gO and gH/gL/pUL128/pUL130/pUL131A complex variants and associated clinical manifestations in infants infected congenitally or postnatally
por: Paradowska, Edyta, et al.
Publicado: (2019)

Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in Virions
por: Vanarsdall, Adam L., et al.
Publicado: (2016)

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry
por: Wu, Yiquan, et al.
Publicado: (2017)

Epstein-Barr virus glycoprotein gH/gL antibodies complement IgA-viral capsid antigen for diagnosis of nasopharyngeal carcinoma
por: Li, Rui-Chen, et al.
Publicado: (2016)

Computational repositioning of ethno medicine elucidated gB-gH-gL complex as novel anti herpes drug target
por: Basha, Syed Hussain, et al.
Publicado: (2013)

The KGD Motif of Epstein-Barr Virus gH/gL Is Bifunctional, Orchestrating Infection of B Cells and Epithelial Cells
por: Chen, Jia, et al.
Publicado: (2012)

Non-redundant and Redundant Roles of Cytomegalovirus gH/gL Complexes in Host Organ Entry and Intra-tissue Spread
por: Lemmermann, Niels A. W., et al.
Publicado: (2015)

The Viral Chemokine MCK-2 of Murine Cytomegalovirus Promotes Infection as Part of a gH/gL/MCK-2 Complex
por: Wagner, Felicia M., et al.
Publicado: (2013)

Novel Epstein-Barr virus-like particles incorporating gH/gL-EBNA1 or gB-LMP2 induce high neutralizing antibody titers and EBV-specific T-cell responses in immunized mice
por: Perez, Elizabeth M., et al.
Publicado: (2016)

Regulation of Herpes Simplex Virus gB-Induced Cell-Cell Fusion by Mutant Forms of gH/gL in the Absence of gD and Cellular Receptors
por: Atanasiu, Doina, et al.
Publicado: (2013)

Tetrameric glycoprotein complex gH/gL/gQ1/gQ2 is a promising vaccine candidate for human herpesvirus 6B
por: Wang, Bochao, et al.
Publicado: (2020)

Fetal Human Cytomegalovirus Transmission Correlates with Delayed Maternal Antibodies to gH/gL/pUL128-130-131 Complex during Primary Infection
por: Lilleri, Daniele, et al.
Publicado: (2013)

Development of broadly neutralizing antibodies targeting the cytomegalovirus subdominant antigen gH
por: Parsons, Andrea J., et al.
Publicado: (2022)

The HCMV gH/gL/UL128-131 Complex Triggers the Specific Cellular Activation Required for Efficient Viral Internalization into Target Monocytes
por: Nogalski, Maciej T., et al.
Publicado: (2013)

Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge
por: Malhi, Harman, et al.
Publicado: (2022)

Receptor Binding-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein D Permit Interaction with the gH/gL Complex to Activate Fusion
por: Atanasiu, Doina, et al.
Publicado: (2023)

Complete Protection of Mice against Lethal Murine Cytomegalovirus Challenge by Immunization with DNA Vaccines Encoding Envelope Glycoprotein Complex III Antigens gH, gL and gO
por: Wang, Huadong, et al.
Publicado: (2015)

Two Sides to Every Story: Herpes Simplex Type-1 Viral Glycoproteins gB, gD, gH/gL, gK, and Cellular Receptors Function as Key Players in Membrane Fusion
por: Jambunathan, Nithya, et al.
Publicado: (2021)

Suppression of DC-SIGN and gH Reveals Complex, Subset-Specific Mechanisms for KSHV Entry in Primary B Lymphocytes
por: Palmerin, Nancy, et al.
Publicado: (2021)

αvβ6- and αvβ8-Integrins Serve As Interchangeable Receptors for HSV gH/gL to Promote Endocytosis and Activation of Membrane Fusion
por: Gianni, Tatiana, et al.
Publicado: (2013)

Active evolution of memory B-cells specific to viral gH/gL/pUL128/130/131 pentameric complex in healthy subjects with silent human cytomegalovirus infection
por: Xia, Lin, et al.
Publicado: (2017)

Amino acid differences in glycoproteins B (gB), C (gC), H (gH) and L(gL) are associated with enhanced herpes simplex virus type-1 (McKrae) entry via the paired immunoglobulin-like type-2 receptor α
por: Chowdhury, Sona, et al.
Publicado: (2012)

Analysis of herpes simplex type 1 gB, gD, and gH/gL on production of infectious HIV-1: HSV-1 gD restricts HIV-1 by exclusion of HIV-1 Env from maturing viral particles
por: Polpitiya Arachchige, Sachith, et al.
Publicado: (2019)

Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV)
por: Großkopf, Anna K., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ksv3oscjt7c48nk3282qr0pir7