BRET-Based Biosensors to Measure Agonist Efficacies in Histamine H(1) Receptor-Mediated G Protein Activation, Signaling and Interactions with GRKs and β-Arrestins

The histamine H(1) receptor (H(1)R) is a G protein-coupled receptor (GPCR) and plays a key role in allergic reactions upon activation by histamine which is locally released from mast cells and basophils. Consequently, H(1)R is a well-established therapeutic target for antihistamines that relieve all...

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Detalles Bibliográficos
Autores principales: Verweij, Eléonore W. E., Bosma, Reggie, Gao, Meichun, van den Bor, Jelle, Al Araaj, Betty, de Munnik, Sabrina M., Ma, Xiaoyuan, Leurs, Rob, Vischer, Henry F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953162/
https://www.ncbi.nlm.nih.gov/pubmed/35328605
http://dx.doi.org/10.3390/ijms23063184

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