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Selecting the Target Population for Screening of Hepatic Fibrosis in Primary Care Centers in Korea

Screening strategies for hepatic fibrosis are heavily focused on patients with fatty liver on sonography in primary care centers. This study aimed to investigate the target population for screening significant hepatic fibrosis in primary care centers. This retrospective cross-sectional cohort study...

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Autores principales: Park, Huiyul, Yoon, Eileen L., Kim, Mimi, Cho, Seon, Kim, Jung-Hwan, Jun, Dae Won, Nah, Eun-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953170/
https://www.ncbi.nlm.nih.gov/pubmed/35329799
http://dx.doi.org/10.3390/jcm11061474
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author Park, Huiyul
Yoon, Eileen L.
Kim, Mimi
Cho, Seon
Kim, Jung-Hwan
Jun, Dae Won
Nah, Eun-Hee
author_facet Park, Huiyul
Yoon, Eileen L.
Kim, Mimi
Cho, Seon
Kim, Jung-Hwan
Jun, Dae Won
Nah, Eun-Hee
author_sort Park, Huiyul
collection PubMed
description Screening strategies for hepatic fibrosis are heavily focused on patients with fatty liver on sonography in primary care centers. This study aimed to investigate the target population for screening significant hepatic fibrosis in primary care centers. This retrospective cross-sectional cohort study used data from 13 nationwide centers. A total of 5111 subjects who underwent both abdominal sonography and magnetic resonance elastography as part of their health check-up were included. Subjects with viral hepatitis and/or a history of significant alcohol consumption were excluded. Significant and advanced hepatic fibrosis was defined as ≥3.0 kPa and ≥3.6 kPa in the MRE test, respectively. The prevalence of significant and advanced hepatic fibrosis was 7.3% and 1.9%, respectively. Among the subjects with significant hepatic fibrosis, 41.3% did not have fatty liver. Hepatic fibrosis burden increased according to the number of metabolic risk abnormalities. Nearly 70% of subjects with significant hepatic fibrosis also had two or more metabolic risk abnormalities and/or diabetes. However, the prevalence of fibrosis did not differ between the groups with and without fatty liver. The presence of two or more metabolic risk abnormalities was an independent risk factor for significant hepatic fibrosis regardless of the fatty liver. Therefore, in the setting of primary care centers, screening for hepatic fibrosis would better be extended to subjects with metabolically unhealthy status beyond those with fatty liver.
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spelling pubmed-89531702022-03-26 Selecting the Target Population for Screening of Hepatic Fibrosis in Primary Care Centers in Korea Park, Huiyul Yoon, Eileen L. Kim, Mimi Cho, Seon Kim, Jung-Hwan Jun, Dae Won Nah, Eun-Hee J Clin Med Article Screening strategies for hepatic fibrosis are heavily focused on patients with fatty liver on sonography in primary care centers. This study aimed to investigate the target population for screening significant hepatic fibrosis in primary care centers. This retrospective cross-sectional cohort study used data from 13 nationwide centers. A total of 5111 subjects who underwent both abdominal sonography and magnetic resonance elastography as part of their health check-up were included. Subjects with viral hepatitis and/or a history of significant alcohol consumption were excluded. Significant and advanced hepatic fibrosis was defined as ≥3.0 kPa and ≥3.6 kPa in the MRE test, respectively. The prevalence of significant and advanced hepatic fibrosis was 7.3% and 1.9%, respectively. Among the subjects with significant hepatic fibrosis, 41.3% did not have fatty liver. Hepatic fibrosis burden increased according to the number of metabolic risk abnormalities. Nearly 70% of subjects with significant hepatic fibrosis also had two or more metabolic risk abnormalities and/or diabetes. However, the prevalence of fibrosis did not differ between the groups with and without fatty liver. The presence of two or more metabolic risk abnormalities was an independent risk factor for significant hepatic fibrosis regardless of the fatty liver. Therefore, in the setting of primary care centers, screening for hepatic fibrosis would better be extended to subjects with metabolically unhealthy status beyond those with fatty liver. MDPI 2022-03-08 /pmc/articles/PMC8953170/ /pubmed/35329799 http://dx.doi.org/10.3390/jcm11061474 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Huiyul
Yoon, Eileen L.
Kim, Mimi
Cho, Seon
Kim, Jung-Hwan
Jun, Dae Won
Nah, Eun-Hee
Selecting the Target Population for Screening of Hepatic Fibrosis in Primary Care Centers in Korea
title Selecting the Target Population for Screening of Hepatic Fibrosis in Primary Care Centers in Korea
title_full Selecting the Target Population for Screening of Hepatic Fibrosis in Primary Care Centers in Korea
title_fullStr Selecting the Target Population for Screening of Hepatic Fibrosis in Primary Care Centers in Korea
title_full_unstemmed Selecting the Target Population for Screening of Hepatic Fibrosis in Primary Care Centers in Korea
title_short Selecting the Target Population for Screening of Hepatic Fibrosis in Primary Care Centers in Korea
title_sort selecting the target population for screening of hepatic fibrosis in primary care centers in korea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953170/
https://www.ncbi.nlm.nih.gov/pubmed/35329799
http://dx.doi.org/10.3390/jcm11061474
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