Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital

Due to Coronavirus disease (COVID-19) a new group of patients at risk emerged with COVID-19-associated mucormycosis (CAM). Systematic studies, evaluating the prevalence of CAM are missing. To assess CAM prevalence in a tertiary care hospital in Germany, we applied direct microscopy, fungal culture a...

Descripción completa

Detalles Bibliográficos
Autores principales: Scharmann, Ulrike, Herbstreit, Frank, Steckel, Nina Kristin, Dedy, Jutta, Buer, Jan, Rath, Peter-Michael, Verhasselt, Hedda Luise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953274/
https://www.ncbi.nlm.nih.gov/pubmed/35330309
http://dx.doi.org/10.3390/jof8030307
_version_ 1784675808801980416
author Scharmann, Ulrike
Herbstreit, Frank
Steckel, Nina Kristin
Dedy, Jutta
Buer, Jan
Rath, Peter-Michael
Verhasselt, Hedda Luise
author_facet Scharmann, Ulrike
Herbstreit, Frank
Steckel, Nina Kristin
Dedy, Jutta
Buer, Jan
Rath, Peter-Michael
Verhasselt, Hedda Luise
author_sort Scharmann, Ulrike
collection PubMed
description Due to Coronavirus disease (COVID-19) a new group of patients at risk emerged with COVID-19-associated mucormycosis (CAM). Systematic studies, evaluating the prevalence of CAM are missing. To assess CAM prevalence in a tertiary care hospital in Germany, we applied direct microscopy, fungal culture and quantitative realtime in-house PCR targeting Mucorales-specific fragments of 18S and 28S rRNA on respiratory specimens of 100 critically ill COVID-19 patients. Overall, one Mucorales-PCR positive bronchoalevolar lavage was found whereas direct microscopy and fungal culture were negative in all cases. We conclude that a routine screening for CAM in Germany is not indicated.
format Online
Article
Text
id pubmed-8953274
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89532742022-03-26 Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital Scharmann, Ulrike Herbstreit, Frank Steckel, Nina Kristin Dedy, Jutta Buer, Jan Rath, Peter-Michael Verhasselt, Hedda Luise J Fungi (Basel) Article Due to Coronavirus disease (COVID-19) a new group of patients at risk emerged with COVID-19-associated mucormycosis (CAM). Systematic studies, evaluating the prevalence of CAM are missing. To assess CAM prevalence in a tertiary care hospital in Germany, we applied direct microscopy, fungal culture and quantitative realtime in-house PCR targeting Mucorales-specific fragments of 18S and 28S rRNA on respiratory specimens of 100 critically ill COVID-19 patients. Overall, one Mucorales-PCR positive bronchoalevolar lavage was found whereas direct microscopy and fungal culture were negative in all cases. We conclude that a routine screening for CAM in Germany is not indicated. MDPI 2022-03-17 /pmc/articles/PMC8953274/ /pubmed/35330309 http://dx.doi.org/10.3390/jof8030307 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scharmann, Ulrike
Herbstreit, Frank
Steckel, Nina Kristin
Dedy, Jutta
Buer, Jan
Rath, Peter-Michael
Verhasselt, Hedda Luise
Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital
title Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital
title_full Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital
title_fullStr Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital
title_full_unstemmed Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital
title_short Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital
title_sort prevalence of covid-19 associated mucormycosis in a german tertiary care hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953274/
https://www.ncbi.nlm.nih.gov/pubmed/35330309
http://dx.doi.org/10.3390/jof8030307
work_keys_str_mv AT scharmannulrike prevalenceofcovid19associatedmucormycosisinagermantertiarycarehospital
AT herbstreitfrank prevalenceofcovid19associatedmucormycosisinagermantertiarycarehospital
AT steckelninakristin prevalenceofcovid19associatedmucormycosisinagermantertiarycarehospital
AT dedyjutta prevalenceofcovid19associatedmucormycosisinagermantertiarycarehospital
AT buerjan prevalenceofcovid19associatedmucormycosisinagermantertiarycarehospital
AT rathpetermichael prevalenceofcovid19associatedmucormycosisinagermantertiarycarehospital
AT verhasseltheddaluise prevalenceofcovid19associatedmucormycosisinagermantertiarycarehospital

Ejemplares similares