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Seroprevalence of Zika Virus in Amphawa District, Thailand, after the 2016 Pandemic

In 2016, Zika virus (ZIKV) infection was declared a public health emergency of international concern because of the neurological consequences in babies born to infected people. Because of the mild and nonspecific symptoms, serological tests are essential in epidemiological studies. However, cross-re...

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Autores principales: Sirinam, Salin, Chatchen, Supawat, Arunsodsai, Watcharee, Guharat, Suriya, Limkittikul, Kriengsak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953292/
https://www.ncbi.nlm.nih.gov/pubmed/35336883
http://dx.doi.org/10.3390/v14030476
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author Sirinam, Salin
Chatchen, Supawat
Arunsodsai, Watcharee
Guharat, Suriya
Limkittikul, Kriengsak
author_facet Sirinam, Salin
Chatchen, Supawat
Arunsodsai, Watcharee
Guharat, Suriya
Limkittikul, Kriengsak
author_sort Sirinam, Salin
collection PubMed
description In 2016, Zika virus (ZIKV) infection was declared a public health emergency of international concern because of the neurological consequences in babies born to infected people. Because of the mild and nonspecific symptoms, serological tests are essential in epidemiological studies. However, cross-reactive antibodies between other Flaviviridae members may complicate the interpretation of results of these tests. This study investigated the seroprevalence of ZIKV infection in Samut Songkhram in central Thailand which was affected by the Zika outbreak of 2016. Three hundred and fifty volunteers aged 5–50 years in Amphawa District, Samut Songkhram, were enrolled between April 2017 and April 2018. ZIKV nonstructural protein 1 (NS1) immunoglobulin G enzyme-linked immunosorbent assay (ELISA) was used to screen serum samples collected on the first day of enrollment and after 6 and 12 months. The seroprevalence and seroconversion of ZIKV were assessed. Cases of ZIKV seroconversion were verified as evidence of ZIKV infection by NS1 blockade-of-binding ELISA and plaque reduction neutralization test (PRNT50). ZIKV seroprevalence in Amphawa was 15.1–17.8% with no significant change over the year. The total seroconversion rate throughout the year was 7/100 person-years. The ratio of asymptomatic to symptomatic infections was 4.5:1. The cases in our study confirmed the occurrence of occult ZIKV infections in the community. These undetected infections might promote the spread of ZIKV in vulnerable groups of the community.
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spelling pubmed-89532922022-03-26 Seroprevalence of Zika Virus in Amphawa District, Thailand, after the 2016 Pandemic Sirinam, Salin Chatchen, Supawat Arunsodsai, Watcharee Guharat, Suriya Limkittikul, Kriengsak Viruses Article In 2016, Zika virus (ZIKV) infection was declared a public health emergency of international concern because of the neurological consequences in babies born to infected people. Because of the mild and nonspecific symptoms, serological tests are essential in epidemiological studies. However, cross-reactive antibodies between other Flaviviridae members may complicate the interpretation of results of these tests. This study investigated the seroprevalence of ZIKV infection in Samut Songkhram in central Thailand which was affected by the Zika outbreak of 2016. Three hundred and fifty volunteers aged 5–50 years in Amphawa District, Samut Songkhram, were enrolled between April 2017 and April 2018. ZIKV nonstructural protein 1 (NS1) immunoglobulin G enzyme-linked immunosorbent assay (ELISA) was used to screen serum samples collected on the first day of enrollment and after 6 and 12 months. The seroprevalence and seroconversion of ZIKV were assessed. Cases of ZIKV seroconversion were verified as evidence of ZIKV infection by NS1 blockade-of-binding ELISA and plaque reduction neutralization test (PRNT50). ZIKV seroprevalence in Amphawa was 15.1–17.8% with no significant change over the year. The total seroconversion rate throughout the year was 7/100 person-years. The ratio of asymptomatic to symptomatic infections was 4.5:1. The cases in our study confirmed the occurrence of occult ZIKV infections in the community. These undetected infections might promote the spread of ZIKV in vulnerable groups of the community. MDPI 2022-02-25 /pmc/articles/PMC8953292/ /pubmed/35336883 http://dx.doi.org/10.3390/v14030476 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sirinam, Salin
Chatchen, Supawat
Arunsodsai, Watcharee
Guharat, Suriya
Limkittikul, Kriengsak
Seroprevalence of Zika Virus in Amphawa District, Thailand, after the 2016 Pandemic
title Seroprevalence of Zika Virus in Amphawa District, Thailand, after the 2016 Pandemic
title_full Seroprevalence of Zika Virus in Amphawa District, Thailand, after the 2016 Pandemic
title_fullStr Seroprevalence of Zika Virus in Amphawa District, Thailand, after the 2016 Pandemic
title_full_unstemmed Seroprevalence of Zika Virus in Amphawa District, Thailand, after the 2016 Pandemic
title_short Seroprevalence of Zika Virus in Amphawa District, Thailand, after the 2016 Pandemic
title_sort seroprevalence of zika virus in amphawa district, thailand, after the 2016 pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953292/
https://www.ncbi.nlm.nih.gov/pubmed/35336883
http://dx.doi.org/10.3390/v14030476
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