Cargando…

Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever

Ichthyoses are hereditary cornification disorders that manifest with abnormal differentiation and desquamation of keratinocytes in a form of generalized dry and scaly skin. In golden retriever dogs, autosomal recessive congenital ichthyosis (ARCI) has been associated with mutations in the PNPLA 1 ge...

Descripción completa

Detalles Bibliográficos
Autores principales: Petak, Ana, Šoštarić-Zuckermann, Ivan-Conrado, Hohšteter, Marko, Lemo, Nikša
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953346/
https://www.ncbi.nlm.nih.gov/pubmed/35324825
http://dx.doi.org/10.3390/vetsci9030097
_version_ 1784675828236288000
author Petak, Ana
Šoštarić-Zuckermann, Ivan-Conrado
Hohšteter, Marko
Lemo, Nikša
author_facet Petak, Ana
Šoštarić-Zuckermann, Ivan-Conrado
Hohšteter, Marko
Lemo, Nikša
author_sort Petak, Ana
collection PubMed
description Ichthyoses are hereditary cornification disorders that manifest with abnormal differentiation and desquamation of keratinocytes in a form of generalized dry and scaly skin. In golden retriever dogs, autosomal recessive congenital ichthyosis (ARCI) has been associated with mutations in the PNPLA 1 gene. In human medicine, isotretinoin is frequently used to treat ARCIs. The aim of this study was to investigate the clinical and histological effects of isotretinoin on ARCI in a golden retriever dog with confirmed mutation in the PNPLA 1 gene. Clinical examination, blood analysis and histopathological examinations were conducted before and after 90 days of isotretinoin therapy. The clinical and histopathological findings indicate that treatment with oral isotretinoin was effective in improving ichthyosis without any side-effects.
format Online
Article
Text
id pubmed-8953346
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89533462022-03-26 Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever Petak, Ana Šoštarić-Zuckermann, Ivan-Conrado Hohšteter, Marko Lemo, Nikša Vet Sci Case Report Ichthyoses are hereditary cornification disorders that manifest with abnormal differentiation and desquamation of keratinocytes in a form of generalized dry and scaly skin. In golden retriever dogs, autosomal recessive congenital ichthyosis (ARCI) has been associated with mutations in the PNPLA 1 gene. In human medicine, isotretinoin is frequently used to treat ARCIs. The aim of this study was to investigate the clinical and histological effects of isotretinoin on ARCI in a golden retriever dog with confirmed mutation in the PNPLA 1 gene. Clinical examination, blood analysis and histopathological examinations were conducted before and after 90 days of isotretinoin therapy. The clinical and histopathological findings indicate that treatment with oral isotretinoin was effective in improving ichthyosis without any side-effects. MDPI 2022-02-22 /pmc/articles/PMC8953346/ /pubmed/35324825 http://dx.doi.org/10.3390/vetsci9030097 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Petak, Ana
Šoštarić-Zuckermann, Ivan-Conrado
Hohšteter, Marko
Lemo, Nikša
Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever
title Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever
title_full Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever
title_fullStr Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever
title_full_unstemmed Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever
title_short Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever
title_sort isotretinoin treatment for autosomal recessive congenital ichthyosis in a golden retriever
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953346/
https://www.ncbi.nlm.nih.gov/pubmed/35324825
http://dx.doi.org/10.3390/vetsci9030097
work_keys_str_mv AT petakana isotretinointreatmentforautosomalrecessivecongenitalichthyosisinagoldenretriever
AT sostariczuckermannivanconrado isotretinointreatmentforautosomalrecessivecongenitalichthyosisinagoldenretriever
AT hohstetermarko isotretinointreatmentforautosomalrecessivecongenitalichthyosisinagoldenretriever
AT lemoniksa isotretinointreatmentforautosomalrecessivecongenitalichthyosisinagoldenretriever