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Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever
Ichthyoses are hereditary cornification disorders that manifest with abnormal differentiation and desquamation of keratinocytes in a form of generalized dry and scaly skin. In golden retriever dogs, autosomal recessive congenital ichthyosis (ARCI) has been associated with mutations in the PNPLA 1 ge...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953346/ https://www.ncbi.nlm.nih.gov/pubmed/35324825 http://dx.doi.org/10.3390/vetsci9030097 |
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author | Petak, Ana Šoštarić-Zuckermann, Ivan-Conrado Hohšteter, Marko Lemo, Nikša |
author_facet | Petak, Ana Šoštarić-Zuckermann, Ivan-Conrado Hohšteter, Marko Lemo, Nikša |
author_sort | Petak, Ana |
collection | PubMed |
description | Ichthyoses are hereditary cornification disorders that manifest with abnormal differentiation and desquamation of keratinocytes in a form of generalized dry and scaly skin. In golden retriever dogs, autosomal recessive congenital ichthyosis (ARCI) has been associated with mutations in the PNPLA 1 gene. In human medicine, isotretinoin is frequently used to treat ARCIs. The aim of this study was to investigate the clinical and histological effects of isotretinoin on ARCI in a golden retriever dog with confirmed mutation in the PNPLA 1 gene. Clinical examination, blood analysis and histopathological examinations were conducted before and after 90 days of isotretinoin therapy. The clinical and histopathological findings indicate that treatment with oral isotretinoin was effective in improving ichthyosis without any side-effects. |
format | Online Article Text |
id | pubmed-8953346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89533462022-03-26 Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever Petak, Ana Šoštarić-Zuckermann, Ivan-Conrado Hohšteter, Marko Lemo, Nikša Vet Sci Case Report Ichthyoses are hereditary cornification disorders that manifest with abnormal differentiation and desquamation of keratinocytes in a form of generalized dry and scaly skin. In golden retriever dogs, autosomal recessive congenital ichthyosis (ARCI) has been associated with mutations in the PNPLA 1 gene. In human medicine, isotretinoin is frequently used to treat ARCIs. The aim of this study was to investigate the clinical and histological effects of isotretinoin on ARCI in a golden retriever dog with confirmed mutation in the PNPLA 1 gene. Clinical examination, blood analysis and histopathological examinations were conducted before and after 90 days of isotretinoin therapy. The clinical and histopathological findings indicate that treatment with oral isotretinoin was effective in improving ichthyosis without any side-effects. MDPI 2022-02-22 /pmc/articles/PMC8953346/ /pubmed/35324825 http://dx.doi.org/10.3390/vetsci9030097 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Petak, Ana Šoštarić-Zuckermann, Ivan-Conrado Hohšteter, Marko Lemo, Nikša Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever |
title | Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever |
title_full | Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever |
title_fullStr | Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever |
title_full_unstemmed | Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever |
title_short | Isotretinoin Treatment for Autosomal Recessive Congenital Ichthyosis in a Golden Retriever |
title_sort | isotretinoin treatment for autosomal recessive congenital ichthyosis in a golden retriever |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953346/ https://www.ncbi.nlm.nih.gov/pubmed/35324825 http://dx.doi.org/10.3390/vetsci9030097 |
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