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Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH

Non-alcoholic fatty liver (NAFLD) over the past years has become a metabolic pandemic linked to a collection of metabolic diseases. The nuclear receptors ERRs, REV-ERBs, RORs, FXR, PPARs, and LXR are master regulators of metabolism and liver physiology. The characterization of these nuclear receptor...

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Autores principales: Welch, Ryan D., Billon, Cyrielle, Losby, McKenna, Bedia-Diaz, Gonzalo, Fang, Yuanying, Avdagic, Amer, Elgendy, Bahaa, Burris, Thomas P., Griffett, Kristine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953348/
https://www.ncbi.nlm.nih.gov/pubmed/35323681
http://dx.doi.org/10.3390/metabo12030238
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author Welch, Ryan D.
Billon, Cyrielle
Losby, McKenna
Bedia-Diaz, Gonzalo
Fang, Yuanying
Avdagic, Amer
Elgendy, Bahaa
Burris, Thomas P.
Griffett, Kristine
author_facet Welch, Ryan D.
Billon, Cyrielle
Losby, McKenna
Bedia-Diaz, Gonzalo
Fang, Yuanying
Avdagic, Amer
Elgendy, Bahaa
Burris, Thomas P.
Griffett, Kristine
author_sort Welch, Ryan D.
collection PubMed
description Non-alcoholic fatty liver (NAFLD) over the past years has become a metabolic pandemic linked to a collection of metabolic diseases. The nuclear receptors ERRs, REV-ERBs, RORs, FXR, PPARs, and LXR are master regulators of metabolism and liver physiology. The characterization of these nuclear receptors and their biology has promoted the development of synthetic ligands. The possibility of targeting these receptors to treat NAFLD is promising, as several compounds including Cilofexor, thiazolidinediones, and Saroglitazar are currently undergoing clinical trials. This review focuses on the latest development of the pharmacology of these metabolic nuclear receptors and how they may be utilized to treat NAFLD and subsequent comorbidities.
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spelling pubmed-89533482022-03-26 Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH Welch, Ryan D. Billon, Cyrielle Losby, McKenna Bedia-Diaz, Gonzalo Fang, Yuanying Avdagic, Amer Elgendy, Bahaa Burris, Thomas P. Griffett, Kristine Metabolites Review Non-alcoholic fatty liver (NAFLD) over the past years has become a metabolic pandemic linked to a collection of metabolic diseases. The nuclear receptors ERRs, REV-ERBs, RORs, FXR, PPARs, and LXR are master regulators of metabolism and liver physiology. The characterization of these nuclear receptors and their biology has promoted the development of synthetic ligands. The possibility of targeting these receptors to treat NAFLD is promising, as several compounds including Cilofexor, thiazolidinediones, and Saroglitazar are currently undergoing clinical trials. This review focuses on the latest development of the pharmacology of these metabolic nuclear receptors and how they may be utilized to treat NAFLD and subsequent comorbidities. MDPI 2022-03-11 /pmc/articles/PMC8953348/ /pubmed/35323681 http://dx.doi.org/10.3390/metabo12030238 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Welch, Ryan D.
Billon, Cyrielle
Losby, McKenna
Bedia-Diaz, Gonzalo
Fang, Yuanying
Avdagic, Amer
Elgendy, Bahaa
Burris, Thomas P.
Griffett, Kristine
Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH
title Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH
title_full Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH
title_fullStr Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH
title_full_unstemmed Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH
title_short Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH
title_sort emerging role of nuclear receptors for the treatment of nafld and nash
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953348/
https://www.ncbi.nlm.nih.gov/pubmed/35323681
http://dx.doi.org/10.3390/metabo12030238
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