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Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH
Non-alcoholic fatty liver (NAFLD) over the past years has become a metabolic pandemic linked to a collection of metabolic diseases. The nuclear receptors ERRs, REV-ERBs, RORs, FXR, PPARs, and LXR are master regulators of metabolism and liver physiology. The characterization of these nuclear receptor...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953348/ https://www.ncbi.nlm.nih.gov/pubmed/35323681 http://dx.doi.org/10.3390/metabo12030238 |
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author | Welch, Ryan D. Billon, Cyrielle Losby, McKenna Bedia-Diaz, Gonzalo Fang, Yuanying Avdagic, Amer Elgendy, Bahaa Burris, Thomas P. Griffett, Kristine |
author_facet | Welch, Ryan D. Billon, Cyrielle Losby, McKenna Bedia-Diaz, Gonzalo Fang, Yuanying Avdagic, Amer Elgendy, Bahaa Burris, Thomas P. Griffett, Kristine |
author_sort | Welch, Ryan D. |
collection | PubMed |
description | Non-alcoholic fatty liver (NAFLD) over the past years has become a metabolic pandemic linked to a collection of metabolic diseases. The nuclear receptors ERRs, REV-ERBs, RORs, FXR, PPARs, and LXR are master regulators of metabolism and liver physiology. The characterization of these nuclear receptors and their biology has promoted the development of synthetic ligands. The possibility of targeting these receptors to treat NAFLD is promising, as several compounds including Cilofexor, thiazolidinediones, and Saroglitazar are currently undergoing clinical trials. This review focuses on the latest development of the pharmacology of these metabolic nuclear receptors and how they may be utilized to treat NAFLD and subsequent comorbidities. |
format | Online Article Text |
id | pubmed-8953348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89533482022-03-26 Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH Welch, Ryan D. Billon, Cyrielle Losby, McKenna Bedia-Diaz, Gonzalo Fang, Yuanying Avdagic, Amer Elgendy, Bahaa Burris, Thomas P. Griffett, Kristine Metabolites Review Non-alcoholic fatty liver (NAFLD) over the past years has become a metabolic pandemic linked to a collection of metabolic diseases. The nuclear receptors ERRs, REV-ERBs, RORs, FXR, PPARs, and LXR are master regulators of metabolism and liver physiology. The characterization of these nuclear receptors and their biology has promoted the development of synthetic ligands. The possibility of targeting these receptors to treat NAFLD is promising, as several compounds including Cilofexor, thiazolidinediones, and Saroglitazar are currently undergoing clinical trials. This review focuses on the latest development of the pharmacology of these metabolic nuclear receptors and how they may be utilized to treat NAFLD and subsequent comorbidities. MDPI 2022-03-11 /pmc/articles/PMC8953348/ /pubmed/35323681 http://dx.doi.org/10.3390/metabo12030238 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Welch, Ryan D. Billon, Cyrielle Losby, McKenna Bedia-Diaz, Gonzalo Fang, Yuanying Avdagic, Amer Elgendy, Bahaa Burris, Thomas P. Griffett, Kristine Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH |
title | Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH |
title_full | Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH |
title_fullStr | Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH |
title_full_unstemmed | Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH |
title_short | Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH |
title_sort | emerging role of nuclear receptors for the treatment of nafld and nash |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953348/ https://www.ncbi.nlm.nih.gov/pubmed/35323681 http://dx.doi.org/10.3390/metabo12030238 |
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