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The Interplay between Tumour Microenvironment Components in Malignant Melanoma

Malignant melanoma has shown an increasing incidence during the last two decades, exhibiting a large spectrum of locations and clinicopathological characteristics. Although current histopathological, biochemical, immunohistochemical, and molecular methods provide a deep insight into its biological b...

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Autores principales: Amalinei, Cornelia, Grigoraș, Adriana, Lozneanu, Ludmila, Căruntu, Irina-Draga, Giușcă, Simona-Eliza, Balan, Raluca Anca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953474/
https://www.ncbi.nlm.nih.gov/pubmed/35334544
http://dx.doi.org/10.3390/medicina58030365
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author Amalinei, Cornelia
Grigoraș, Adriana
Lozneanu, Ludmila
Căruntu, Irina-Draga
Giușcă, Simona-Eliza
Balan, Raluca Anca
author_facet Amalinei, Cornelia
Grigoraș, Adriana
Lozneanu, Ludmila
Căruntu, Irina-Draga
Giușcă, Simona-Eliza
Balan, Raluca Anca
author_sort Amalinei, Cornelia
collection PubMed
description Malignant melanoma has shown an increasing incidence during the last two decades, exhibiting a large spectrum of locations and clinicopathological characteristics. Although current histopathological, biochemical, immunohistochemical, and molecular methods provide a deep insight into its biological behaviour and outcome, melanoma is still an unpredictable disease, with poor outcome. This review of the literature is aimed at updating the knowledge regarding melanoma’s clinicopathological and molecular hallmarks, including its heterogeneity and plasticity, involving cancer stem cells population. A special focus is given on the interplay between different cellular components and their secretion products in melanoma, considering its contribution to tumour progression, invasion, metastasis, recurrences, and resistance to classical therapy. Furthermore, the influences of the specific tumour microenvironment or “inflammasome”, its association with adipose tissue products, including the release of “extracellular vesicles”, and distinct microbiota are currently studied, considering their influences on diagnosis and prognosis. An insight into melanoma’s particular features may reveal new molecular pathways which may be exploited in order to develop innovative therapeutic approaches or tailored therapy.
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spelling pubmed-89534742022-03-26 The Interplay between Tumour Microenvironment Components in Malignant Melanoma Amalinei, Cornelia Grigoraș, Adriana Lozneanu, Ludmila Căruntu, Irina-Draga Giușcă, Simona-Eliza Balan, Raluca Anca Medicina (Kaunas) Review Malignant melanoma has shown an increasing incidence during the last two decades, exhibiting a large spectrum of locations and clinicopathological characteristics. Although current histopathological, biochemical, immunohistochemical, and molecular methods provide a deep insight into its biological behaviour and outcome, melanoma is still an unpredictable disease, with poor outcome. This review of the literature is aimed at updating the knowledge regarding melanoma’s clinicopathological and molecular hallmarks, including its heterogeneity and plasticity, involving cancer stem cells population. A special focus is given on the interplay between different cellular components and their secretion products in melanoma, considering its contribution to tumour progression, invasion, metastasis, recurrences, and resistance to classical therapy. Furthermore, the influences of the specific tumour microenvironment or “inflammasome”, its association with adipose tissue products, including the release of “extracellular vesicles”, and distinct microbiota are currently studied, considering their influences on diagnosis and prognosis. An insight into melanoma’s particular features may reveal new molecular pathways which may be exploited in order to develop innovative therapeutic approaches or tailored therapy. MDPI 2022-03-02 /pmc/articles/PMC8953474/ /pubmed/35334544 http://dx.doi.org/10.3390/medicina58030365 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Amalinei, Cornelia
Grigoraș, Adriana
Lozneanu, Ludmila
Căruntu, Irina-Draga
Giușcă, Simona-Eliza
Balan, Raluca Anca
The Interplay between Tumour Microenvironment Components in Malignant Melanoma
title The Interplay between Tumour Microenvironment Components in Malignant Melanoma
title_full The Interplay between Tumour Microenvironment Components in Malignant Melanoma
title_fullStr The Interplay between Tumour Microenvironment Components in Malignant Melanoma
title_full_unstemmed The Interplay between Tumour Microenvironment Components in Malignant Melanoma
title_short The Interplay between Tumour Microenvironment Components in Malignant Melanoma
title_sort interplay between tumour microenvironment components in malignant melanoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953474/
https://www.ncbi.nlm.nih.gov/pubmed/35334544
http://dx.doi.org/10.3390/medicina58030365
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