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The Moderating Role of the FKBP5 Gene Polymorphisms in the Relationship between Attachment Style, Perceived Stress and Psychotic-like Experiences in Non-Clinical Young Adults

Numerous studies have reported that stressful life experiences increase the risk of psychosis and psychotic-like experiences (PLEs). Common variations of the FKBP5 gene have been reported to impact the risk of psychosis by moderating the effects of environmental exposures. Moreover, anxious and avoi...

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Autores principales: Stramecki, Filip, Misiak, Błażej, Gawęda, Łukasz, Prochwicz, Katarzyna, Kłosowska, Joanna, Samochowiec, Jerzy, Samochowiec, Agnieszka, Pawlak, Edyta, Szmida, Elżbieta, Skiba, Paweł, Cechnicki, Andrzej, Frydecka, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953491/
https://www.ncbi.nlm.nih.gov/pubmed/35329940
http://dx.doi.org/10.3390/jcm11061614
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author Stramecki, Filip
Misiak, Błażej
Gawęda, Łukasz
Prochwicz, Katarzyna
Kłosowska, Joanna
Samochowiec, Jerzy
Samochowiec, Agnieszka
Pawlak, Edyta
Szmida, Elżbieta
Skiba, Paweł
Cechnicki, Andrzej
Frydecka, Dorota
author_facet Stramecki, Filip
Misiak, Błażej
Gawęda, Łukasz
Prochwicz, Katarzyna
Kłosowska, Joanna
Samochowiec, Jerzy
Samochowiec, Agnieszka
Pawlak, Edyta
Szmida, Elżbieta
Skiba, Paweł
Cechnicki, Andrzej
Frydecka, Dorota
author_sort Stramecki, Filip
collection PubMed
description Numerous studies have reported that stressful life experiences increase the risk of psychosis and psychotic-like experiences (PLEs). Common variations of the FKBP5 gene have been reported to impact the risk of psychosis by moderating the effects of environmental exposures. Moreover, anxious and avoidant attachment styles have been shown to increase both the level of perceived stress and the risk for psychosis development. In the present cross-sectional study, we aimed to investigate whether variants of the FKBP5 gene moderate the effects of attachment styles and the level of perceived stress on the development of PLEs. A total of 535 non-clinical undergraduates were genotyped for six FKBP5 single nucleotide polymorphisms (SNPs) (rs3800373, rs9470080, rs4713902, rs737054, rs1360780 and rs9296158). The Psychosis Attachment Measure (PAM), the Perceived Stress Scale-10 (PSS-10) and the Prodromal Questionnaire 16 (PQ-16) were administered to assess attachment styles, the level of perceived stress and PLEs, respectively. Anxious attachment style, lower levels of perceived self-efficacy and higher levels of perceived helplessness were associated with a significantly higher number of PLEs. The main effects of attachment style on the severity of PLEs were significant in models testing for the associations with perceived self-efficacy and three FKBP5 SNPs (rs1360780, rs9296158 and rs9470080). The main effect of rs38003733 on the number of PLEs was observed, with GG homozygotes reporting a significantly higher number of PLEs in comparison to T allele carriers. In individuals with dominant anxious attachment style, there was a significant effect of the interaction between the FKBP5 rs4713902 SNP and self-efficacy on the severity of PLEs. Among rs4713902 TT homozygotes, a low level of perceived self-efficacy was associated with higher severity of PLEs. In subjects with non-dominant anxious attachment, a low level of perceived self-efficacy was associated with a higher number of PLEs, regardless of the genotype. Our results indicate that the FKBP5 gene might moderate the relationship between attachment, perceived stress and PLEs.
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spelling pubmed-89534912022-03-26 The Moderating Role of the FKBP5 Gene Polymorphisms in the Relationship between Attachment Style, Perceived Stress and Psychotic-like Experiences in Non-Clinical Young Adults Stramecki, Filip Misiak, Błażej Gawęda, Łukasz Prochwicz, Katarzyna Kłosowska, Joanna Samochowiec, Jerzy Samochowiec, Agnieszka Pawlak, Edyta Szmida, Elżbieta Skiba, Paweł Cechnicki, Andrzej Frydecka, Dorota J Clin Med Article Numerous studies have reported that stressful life experiences increase the risk of psychosis and psychotic-like experiences (PLEs). Common variations of the FKBP5 gene have been reported to impact the risk of psychosis by moderating the effects of environmental exposures. Moreover, anxious and avoidant attachment styles have been shown to increase both the level of perceived stress and the risk for psychosis development. In the present cross-sectional study, we aimed to investigate whether variants of the FKBP5 gene moderate the effects of attachment styles and the level of perceived stress on the development of PLEs. A total of 535 non-clinical undergraduates were genotyped for six FKBP5 single nucleotide polymorphisms (SNPs) (rs3800373, rs9470080, rs4713902, rs737054, rs1360780 and rs9296158). The Psychosis Attachment Measure (PAM), the Perceived Stress Scale-10 (PSS-10) and the Prodromal Questionnaire 16 (PQ-16) were administered to assess attachment styles, the level of perceived stress and PLEs, respectively. Anxious attachment style, lower levels of perceived self-efficacy and higher levels of perceived helplessness were associated with a significantly higher number of PLEs. The main effects of attachment style on the severity of PLEs were significant in models testing for the associations with perceived self-efficacy and three FKBP5 SNPs (rs1360780, rs9296158 and rs9470080). The main effect of rs38003733 on the number of PLEs was observed, with GG homozygotes reporting a significantly higher number of PLEs in comparison to T allele carriers. In individuals with dominant anxious attachment style, there was a significant effect of the interaction between the FKBP5 rs4713902 SNP and self-efficacy on the severity of PLEs. Among rs4713902 TT homozygotes, a low level of perceived self-efficacy was associated with higher severity of PLEs. In subjects with non-dominant anxious attachment, a low level of perceived self-efficacy was associated with a higher number of PLEs, regardless of the genotype. Our results indicate that the FKBP5 gene might moderate the relationship between attachment, perceived stress and PLEs. MDPI 2022-03-15 /pmc/articles/PMC8953491/ /pubmed/35329940 http://dx.doi.org/10.3390/jcm11061614 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stramecki, Filip
Misiak, Błażej
Gawęda, Łukasz
Prochwicz, Katarzyna
Kłosowska, Joanna
Samochowiec, Jerzy
Samochowiec, Agnieszka
Pawlak, Edyta
Szmida, Elżbieta
Skiba, Paweł
Cechnicki, Andrzej
Frydecka, Dorota
The Moderating Role of the FKBP5 Gene Polymorphisms in the Relationship between Attachment Style, Perceived Stress and Psychotic-like Experiences in Non-Clinical Young Adults
title The Moderating Role of the FKBP5 Gene Polymorphisms in the Relationship between Attachment Style, Perceived Stress and Psychotic-like Experiences in Non-Clinical Young Adults
title_full The Moderating Role of the FKBP5 Gene Polymorphisms in the Relationship between Attachment Style, Perceived Stress and Psychotic-like Experiences in Non-Clinical Young Adults
title_fullStr The Moderating Role of the FKBP5 Gene Polymorphisms in the Relationship between Attachment Style, Perceived Stress and Psychotic-like Experiences in Non-Clinical Young Adults
title_full_unstemmed The Moderating Role of the FKBP5 Gene Polymorphisms in the Relationship between Attachment Style, Perceived Stress and Psychotic-like Experiences in Non-Clinical Young Adults
title_short The Moderating Role of the FKBP5 Gene Polymorphisms in the Relationship between Attachment Style, Perceived Stress and Psychotic-like Experiences in Non-Clinical Young Adults
title_sort moderating role of the fkbp5 gene polymorphisms in the relationship between attachment style, perceived stress and psychotic-like experiences in non-clinical young adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953491/
https://www.ncbi.nlm.nih.gov/pubmed/35329940
http://dx.doi.org/10.3390/jcm11061614
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