Loss of ABCA8B decreases myelination by reducing oligodendrocyte precursor cells in mice

The myelin sheath, which is wrapped around axons, is a lipid-enriched structure produced by mature oligodendrocytes. Disruption of the myelin sheath is observed in several neurological diseases, such as multiple sclerosis. A crucial component of myelin is sphingomyelin, levels of which can be increa...

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Detalles Bibliográficos
Autores principales: Liu, Yiran, Castano, David, Girolamo, Francesco, Trigueros-Motos, Laia, Bae, Han-Gyu, Neo, Suat Peng, Oh, Jeongah, Narayanaswamy, Pradeep, Torta, Federico, Rye, Kerry Anne, Jo, Dong-Gyu, Gunaratne, Jayantha, Jung, Sangyong, Virgintino, Daniela, Singaraja, Roshni R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953628/
https://www.ncbi.nlm.nih.gov/pubmed/34752805
http://dx.doi.org/10.1016/j.jlr.2021.100147

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