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The History of Clinical Islet Transplantation in Japan
Islet transplantation shows the promise of being capable of relieving glucose instability and improving QOL of patients with type 1 diabetes that cannot be controlled due to severe hypoglycemia unawareness. In Japan, following the first human islet isolation from a donor after cardiac death in 2003...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953643/ https://www.ncbi.nlm.nih.gov/pubmed/35329971 http://dx.doi.org/10.3390/jcm11061645 |
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author | Ito, Taihei Kenmochi, Takashi Kurihara, Kei Aida, Naohiro |
author_facet | Ito, Taihei Kenmochi, Takashi Kurihara, Kei Aida, Naohiro |
author_sort | Ito, Taihei |
collection | PubMed |
description | Islet transplantation shows the promise of being capable of relieving glucose instability and improving QOL of patients with type 1 diabetes that cannot be controlled due to severe hypoglycemia unawareness. In Japan, following the first human islet isolation from a donor after cardiac death in 2003 and the first clinical islet transplantation in 2004, islet transplantation was performed for the improvement of type 1 diabetes as a single-center trial in several centers. Although it was discontinued due to the possibility of contamination of collagenase by bovine brain component in 2007, the phase II clinical trial of islet transplantation started using ATG induction and a TNF-α inhibition protocol in 2012. The primary endpoints of this trial were the proportion of patients with HbA1c < 7.4% and freedom from severe hypoglycemic events at one year after the first islet cell infusion. In an interim analysis, this endpoint was achieved in 75% of cases. In April 2020, clinical islet transplantation was finally covered by health insurance in Japan, thanks to these outcomes. We herein introduce more than 20 years of history of clinical islet transplantation in Japan. |
format | Online Article Text |
id | pubmed-8953643 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89536432022-03-26 The History of Clinical Islet Transplantation in Japan Ito, Taihei Kenmochi, Takashi Kurihara, Kei Aida, Naohiro J Clin Med Review Islet transplantation shows the promise of being capable of relieving glucose instability and improving QOL of patients with type 1 diabetes that cannot be controlled due to severe hypoglycemia unawareness. In Japan, following the first human islet isolation from a donor after cardiac death in 2003 and the first clinical islet transplantation in 2004, islet transplantation was performed for the improvement of type 1 diabetes as a single-center trial in several centers. Although it was discontinued due to the possibility of contamination of collagenase by bovine brain component in 2007, the phase II clinical trial of islet transplantation started using ATG induction and a TNF-α inhibition protocol in 2012. The primary endpoints of this trial were the proportion of patients with HbA1c < 7.4% and freedom from severe hypoglycemic events at one year after the first islet cell infusion. In an interim analysis, this endpoint was achieved in 75% of cases. In April 2020, clinical islet transplantation was finally covered by health insurance in Japan, thanks to these outcomes. We herein introduce more than 20 years of history of clinical islet transplantation in Japan. MDPI 2022-03-16 /pmc/articles/PMC8953643/ /pubmed/35329971 http://dx.doi.org/10.3390/jcm11061645 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ito, Taihei Kenmochi, Takashi Kurihara, Kei Aida, Naohiro The History of Clinical Islet Transplantation in Japan |
title | The History of Clinical Islet Transplantation in Japan |
title_full | The History of Clinical Islet Transplantation in Japan |
title_fullStr | The History of Clinical Islet Transplantation in Japan |
title_full_unstemmed | The History of Clinical Islet Transplantation in Japan |
title_short | The History of Clinical Islet Transplantation in Japan |
title_sort | history of clinical islet transplantation in japan |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953643/ https://www.ncbi.nlm.nih.gov/pubmed/35329971 http://dx.doi.org/10.3390/jcm11061645 |
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