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Vitamin D and Parkinson’s Disease
Vitamin D is a fat-soluble secosteroid, traditionally considered a key regulator of bone metabolism, calcium and phosphorous homeostasis. Its action is made possible through the binding to the vitamin D receptor (VDR), after which it directly and indirectly modulates the expression of thousands of g...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953648/ https://www.ncbi.nlm.nih.gov/pubmed/35334877 http://dx.doi.org/10.3390/nu14061220 |
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author | Pignolo, Antonia Mastrilli, Sergio Davì, Chiara Arnao, Valentina Aridon, Paolo dos Santos Mendes, Felipe Augusto Gagliardo, Cesare D’Amelio, Marco |
author_facet | Pignolo, Antonia Mastrilli, Sergio Davì, Chiara Arnao, Valentina Aridon, Paolo dos Santos Mendes, Felipe Augusto Gagliardo, Cesare D’Amelio, Marco |
author_sort | Pignolo, Antonia |
collection | PubMed |
description | Vitamin D is a fat-soluble secosteroid, traditionally considered a key regulator of bone metabolism, calcium and phosphorous homeostasis. Its action is made possible through the binding to the vitamin D receptor (VDR), after which it directly and indirectly modulates the expression of thousands of genes. Vitamin D is important for brain development, mature brain activity and associated with many neurological diseases, including Parkinson’s disease (PD). High frequency of vitamin D deficiency in patients with Parkinson’s disease compared to control population was noted nearly twenty years ago. This finding is of interest given vitamin D’s neuroprotective effect, exerted by the action of neurotrophic factors, regulation of nerve growth or through protection against cytotoxicity. Vitamin D deficiency seems to be related to disease severity and disease progression, evaluated by Unified Parkinson’s Disease Rating Scale (UPDRS) and Hoehn and Yahr (H&Y) scale, but not with age of PD onset and duration of disease. Additionally, fall risk has been associated with lower vitamin D levels in PD. However, while the association between vitamin D and motor-symptoms seems to be possible, results of studies investigating the association with non-motor symptoms are conflicting. In addition, very little evidence exists regarding the possibility to use vitamin D supplementation to reduce clinical manifestations and disability in patients with PD. However, considering the positive balance between potential benefits against its limited risks, vitamin D supplementation for PD patients will probably be considered in the near future, if further confirmed in clinical studies. |
format | Online Article Text |
id | pubmed-8953648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89536482022-03-26 Vitamin D and Parkinson’s Disease Pignolo, Antonia Mastrilli, Sergio Davì, Chiara Arnao, Valentina Aridon, Paolo dos Santos Mendes, Felipe Augusto Gagliardo, Cesare D’Amelio, Marco Nutrients Review Vitamin D is a fat-soluble secosteroid, traditionally considered a key regulator of bone metabolism, calcium and phosphorous homeostasis. Its action is made possible through the binding to the vitamin D receptor (VDR), after which it directly and indirectly modulates the expression of thousands of genes. Vitamin D is important for brain development, mature brain activity and associated with many neurological diseases, including Parkinson’s disease (PD). High frequency of vitamin D deficiency in patients with Parkinson’s disease compared to control population was noted nearly twenty years ago. This finding is of interest given vitamin D’s neuroprotective effect, exerted by the action of neurotrophic factors, regulation of nerve growth or through protection against cytotoxicity. Vitamin D deficiency seems to be related to disease severity and disease progression, evaluated by Unified Parkinson’s Disease Rating Scale (UPDRS) and Hoehn and Yahr (H&Y) scale, but not with age of PD onset and duration of disease. Additionally, fall risk has been associated with lower vitamin D levels in PD. However, while the association between vitamin D and motor-symptoms seems to be possible, results of studies investigating the association with non-motor symptoms are conflicting. In addition, very little evidence exists regarding the possibility to use vitamin D supplementation to reduce clinical manifestations and disability in patients with PD. However, considering the positive balance between potential benefits against its limited risks, vitamin D supplementation for PD patients will probably be considered in the near future, if further confirmed in clinical studies. MDPI 2022-03-14 /pmc/articles/PMC8953648/ /pubmed/35334877 http://dx.doi.org/10.3390/nu14061220 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pignolo, Antonia Mastrilli, Sergio Davì, Chiara Arnao, Valentina Aridon, Paolo dos Santos Mendes, Felipe Augusto Gagliardo, Cesare D’Amelio, Marco Vitamin D and Parkinson’s Disease |
title | Vitamin D and Parkinson’s Disease |
title_full | Vitamin D and Parkinson’s Disease |
title_fullStr | Vitamin D and Parkinson’s Disease |
title_full_unstemmed | Vitamin D and Parkinson’s Disease |
title_short | Vitamin D and Parkinson’s Disease |
title_sort | vitamin d and parkinson’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953648/ https://www.ncbi.nlm.nih.gov/pubmed/35334877 http://dx.doi.org/10.3390/nu14061220 |
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