1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase

Cancer cells may depend on exogenous serine, depletion of which results in slower growth and activation of adaptive metabolic changes. We previously demonstrated that serine and glycine (SG) deprivation causes loss of sphingosine kinase 1 (SK1) in cancer cells, thereby increasing the levels of its l...

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Detalles Bibliográficos
Autores principales: Truman, Jean-Philip, Ruiz, Christian F., Montal, Emily, Garcia-Barros, Monica, Mileva, Izolda, Snider, Ashley J., Hannun, Yusuf A., Obeid, Lina M., Mao, Cungui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953655/
https://www.ncbi.nlm.nih.gov/pubmed/34838542
http://dx.doi.org/10.1016/j.jlr.2021.100154

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