Cholesterol sulfate fluidizes the sterol fraction of the stratum corneum lipid phase and increases its permeability

Desulfation of cholesterol sulfate (CholS) to cholesterol (Chol) is an important event in epidermal homeostasis and necessary for stratum corneum (SC) barrier function. The CholS/Chol ratio decreases during SC maturation but remains high in pathological conditions, such as X-linked ichthyosis, chara...

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Detalles Bibliográficos
Autores principales: Fandrei, Ferdinand, Engberg, Oskar, Opálka, Lukáš, Jančálková, Pavla, Pullmannová, Petra, Steinhart, Miloš, Kováčik, Andrej, Vávrová, Kateřina, Huster, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953687/
https://www.ncbi.nlm.nih.gov/pubmed/35143845
http://dx.doi.org/10.1016/j.jlr.2022.100177

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