Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time?

During the ongoing COVID-19 pandemic, serology has suffered several manufacturing and budget bottlenecks. Kode technology exposes exogenous antigens on the surface of cells; in the case of red blood cells, modified cells are called kodecytes, making antibody–antigen reactions detectable by the old-f...

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Detalles Bibliográficos
Autores principales: Focosi, Daniele, Franchini, Massimo, Maggi, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953758/
https://www.ncbi.nlm.nih.gov/pubmed/35335038
http://dx.doi.org/10.3390/vaccines10030406
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author Focosi, Daniele
Franchini, Massimo
Maggi, Fabrizio
author_facet Focosi, Daniele
Franchini, Massimo
Maggi, Fabrizio
author_sort Focosi, Daniele
collection PubMed
description During the ongoing COVID-19 pandemic, serology has suffered several manufacturing and budget bottlenecks. Kode technology exposes exogenous antigens on the surface of cells; in the case of red blood cells, modified cells are called kodecytes, making antibody–antigen reactions detectable by the old-fashioned hemagglutination test. In this commentary, we review evidence supporting the utility of SARS-CoV-2 Spike kodecytes for clinical diagnostic purposes and serosurveys in resource-poor settings.
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spelling pubmed-89537582022-03-26 Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time? Focosi, Daniele Franchini, Massimo Maggi, Fabrizio Vaccines (Basel) Communication During the ongoing COVID-19 pandemic, serology has suffered several manufacturing and budget bottlenecks. Kode technology exposes exogenous antigens on the surface of cells; in the case of red blood cells, modified cells are called kodecytes, making antibody–antigen reactions detectable by the old-fashioned hemagglutination test. In this commentary, we review evidence supporting the utility of SARS-CoV-2 Spike kodecytes for clinical diagnostic purposes and serosurveys in resource-poor settings. MDPI 2022-03-08 /pmc/articles/PMC8953758/ /pubmed/35335038 http://dx.doi.org/10.3390/vaccines10030406 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Focosi, Daniele
Franchini, Massimo
Maggi, Fabrizio
Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time?
title Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time?
title_full Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time?
title_fullStr Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time?
title_full_unstemmed Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time?
title_short Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time?
title_sort modified hemagglutination tests for covid-19 serology in resource-poor settings: ready for prime-time?
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953758/
https://www.ncbi.nlm.nih.gov/pubmed/35335038
http://dx.doi.org/10.3390/vaccines10030406
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