Cargando…
Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer
Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal, ST6Gal, ST6GalNAc, or ST8SIA with α2,3-, α2,6-, or α2,8-linkages. Alteration of these sialyltransferases causing aberrant sialylation is associated with the progression of colon cancer. However, among the ST8- si...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953768/ https://www.ncbi.nlm.nih.gov/pubmed/35330401 http://dx.doi.org/10.3390/jpm12030401 |
_version_ | 1784675931183382528 |
---|---|
author | Ko, Chou-Yuan Chu, Tian-Huei Hsu, Ching-Cheng Chen, Hsin-Pao Huang, Shih-Chung Chang, Chen-Lin Tzou, Shiow-Jyu Chen, Tung-Yuan Lin, Chia-Chen Shih, Pei-Chun Lin, Chung-Hsien Chang, Chuan-Fa Lee, Yung-Kuo |
author_facet | Ko, Chou-Yuan Chu, Tian-Huei Hsu, Ching-Cheng Chen, Hsin-Pao Huang, Shih-Chung Chang, Chen-Lin Tzou, Shiow-Jyu Chen, Tung-Yuan Lin, Chia-Chen Shih, Pei-Chun Lin, Chung-Hsien Chang, Chuan-Fa Lee, Yung-Kuo |
author_sort | Ko, Chou-Yuan |
collection | PubMed |
description | Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal, ST6Gal, ST6GalNAc, or ST8SIA with α2,3-, α2,6-, or α2,8-linkages. Alteration of these sialyltransferases causing aberrant sialylation is associated with the progression of colon cancer. However, among the ST8- sialyltransferases, the role of ST8SIA6 in colon cancer remains poorly understood. In this study, we explored the involvement of ST8SIA6 in colon cancer using multiple gene databases. The relationship between ST8SIA6 expression and tumor stages/grades was investigated by UALCAN analysis, and Kaplan–Meier Plotter analysis was used to analyze the expression of ST8SIA6 on the survival outcome of colon cancer patients. Moreover, the biological functions of ST8SIA6 in colon cancer were explored using LinkedOmics and cancer cell metabolism gene DB. Finally, TIMER and TISMO analyses were used to delineate ST8SIA6 levels in tumor immunity and immunotherapy responses, respectively. ST8SIA6 downregulation was associated with an advanced stage and poorly differentiated grade; however, ST8SIA6 expression did not affect the survival outcomes in patients with colon cancer. Gene ontology analysis suggested that ST8SIA6 participates in cell surface adhesion, angiogenesis, and membrane vesicle trafficking. In addition, ST8SIA6 levels affected immunocyte infiltration and immunotherapy responses in colon cancer. Collectively, these results suggest that ST8SIA6 may serve as a novel therapeutic target towards personalized medicine for colon cancer. |
format | Online Article Text |
id | pubmed-8953768 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89537682022-03-26 Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer Ko, Chou-Yuan Chu, Tian-Huei Hsu, Ching-Cheng Chen, Hsin-Pao Huang, Shih-Chung Chang, Chen-Lin Tzou, Shiow-Jyu Chen, Tung-Yuan Lin, Chia-Chen Shih, Pei-Chun Lin, Chung-Hsien Chang, Chuan-Fa Lee, Yung-Kuo J Pers Med Article Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal, ST6Gal, ST6GalNAc, or ST8SIA with α2,3-, α2,6-, or α2,8-linkages. Alteration of these sialyltransferases causing aberrant sialylation is associated with the progression of colon cancer. However, among the ST8- sialyltransferases, the role of ST8SIA6 in colon cancer remains poorly understood. In this study, we explored the involvement of ST8SIA6 in colon cancer using multiple gene databases. The relationship between ST8SIA6 expression and tumor stages/grades was investigated by UALCAN analysis, and Kaplan–Meier Plotter analysis was used to analyze the expression of ST8SIA6 on the survival outcome of colon cancer patients. Moreover, the biological functions of ST8SIA6 in colon cancer were explored using LinkedOmics and cancer cell metabolism gene DB. Finally, TIMER and TISMO analyses were used to delineate ST8SIA6 levels in tumor immunity and immunotherapy responses, respectively. ST8SIA6 downregulation was associated with an advanced stage and poorly differentiated grade; however, ST8SIA6 expression did not affect the survival outcomes in patients with colon cancer. Gene ontology analysis suggested that ST8SIA6 participates in cell surface adhesion, angiogenesis, and membrane vesicle trafficking. In addition, ST8SIA6 levels affected immunocyte infiltration and immunotherapy responses in colon cancer. Collectively, these results suggest that ST8SIA6 may serve as a novel therapeutic target towards personalized medicine for colon cancer. MDPI 2022-03-04 /pmc/articles/PMC8953768/ /pubmed/35330401 http://dx.doi.org/10.3390/jpm12030401 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ko, Chou-Yuan Chu, Tian-Huei Hsu, Ching-Cheng Chen, Hsin-Pao Huang, Shih-Chung Chang, Chen-Lin Tzou, Shiow-Jyu Chen, Tung-Yuan Lin, Chia-Chen Shih, Pei-Chun Lin, Chung-Hsien Chang, Chuan-Fa Lee, Yung-Kuo Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer |
title | Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer |
title_full | Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer |
title_fullStr | Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer |
title_full_unstemmed | Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer |
title_short | Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer |
title_sort | bioinformatics analyses identify the therapeutic potential of st8sia6 for colon cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953768/ https://www.ncbi.nlm.nih.gov/pubmed/35330401 http://dx.doi.org/10.3390/jpm12030401 |
work_keys_str_mv | AT kochouyuan bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT chutianhuei bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT hsuchingcheng bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT chenhsinpao bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT huangshihchung bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT changchenlin bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT tzoushiowjyu bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT chentungyuan bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT linchiachen bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT shihpeichun bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT linchunghsien bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT changchuanfa bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer AT leeyungkuo bioinformaticsanalysesidentifythetherapeuticpotentialofst8sia6forcoloncancer |