Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine

The toxicity of mRNA-lipid nanoparticle (LNP) vaccines depends on the total mRNA-LNP dose. We established that the maximum tolerated dose of our trivalent mRNA-LNP genital herpes vaccine was 10 μg/immunization in mice. We then evaluated one of the mRNAs, gD2 mRNA-LNP, to determine how much of the 10...

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Detalles Bibliográficos
Autores principales: Hook, Lauren M., Awasthi, Sita, Cairns, Tina M., Alameh, Mohamad-Gabriel, Fowler, Bernard T., Egan, Kevin P., Sung, Molly M. H., Weissman, Drew, Cohen, Gary H., Friedman, Harvey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953786/
https://www.ncbi.nlm.nih.gov/pubmed/35336946
http://dx.doi.org/10.3390/v14030540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953786/
https://www.ncbi.nlm.nih.gov/pubmed/35336946
http://dx.doi.org/10.3390/v14030540

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