Cargando…

A Six-Year Gynecological Follow-Up of Immunosuppressed Women with a High-Risk Human Papillomavirus Infection

Immunocompromised women are at an increased risk of developing malignancies, especially those that are viral-induced, such as invasive cervical cancer caused by the human papillomavirus (HPV). The aim of the study was to describe gynecological follow-up of women undergoing chronic immunosuppressive...

Descripción completa

Detalles Bibliográficos
Autores principales: Wielgos, Aleksandra, Pietrzak, Bronisława, Suchonska, Barbara, Sikora, Mariusz, Rudnicka, Lidia, Wielgos, Miroslaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953826/
https://www.ncbi.nlm.nih.gov/pubmed/35329222
http://dx.doi.org/10.3390/ijerph19063531
_version_ 1784675945172434944
author Wielgos, Aleksandra
Pietrzak, Bronisława
Suchonska, Barbara
Sikora, Mariusz
Rudnicka, Lidia
Wielgos, Miroslaw
author_facet Wielgos, Aleksandra
Pietrzak, Bronisława
Suchonska, Barbara
Sikora, Mariusz
Rudnicka, Lidia
Wielgos, Miroslaw
author_sort Wielgos, Aleksandra
collection PubMed
description Immunocompromised women are at an increased risk of developing malignancies, especially those that are viral-induced, such as invasive cervical cancer caused by the human papillomavirus (HPV). The aim of the study was to describe gynecological follow-up of women undergoing chronic immunosuppressive therapy for various reasons (e.g., kidney/liver transplant, systemic lupus erythematosus), diagnosed with a high-risk HPV (hrHPV) infection based on a self-sampling test. Twenty-six hrHPV-positive women were invited to take part in a gynecological follow-up, including a visual assessment of the anogenital region, two-handed gynecological examination, and cervical cytology as well as a colposcopy and cervical biopsy when necessary. Four women declined taking part in the study. Over six years of observation, low-grade squamous intraepithelial lesions (LSIL) were detected at least once in 7/22 women (31.8%), and a cervical intraepithelial lesion 1 (CIN 1) histopathologic result was obtained five times in 3/22 women. No cases of high-grade squamous intraepithelial lesions, CIN 2/3, or invasive cervical cancers were observed. Loop electrosurgical excision procedure (LEEP) was performed in three patients. As immunocompromised women are prone to persistent hrHPV infections, they should be under strict gynecological supervision because only vigilant surveillance enables fast detection and treatment of early dysplasia and, therefore, provides a chance for the reduction of the cervical cancer burden.
format Online
Article
Text
id pubmed-8953826
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89538262022-03-26 A Six-Year Gynecological Follow-Up of Immunosuppressed Women with a High-Risk Human Papillomavirus Infection Wielgos, Aleksandra Pietrzak, Bronisława Suchonska, Barbara Sikora, Mariusz Rudnicka, Lidia Wielgos, Miroslaw Int J Environ Res Public Health Article Immunocompromised women are at an increased risk of developing malignancies, especially those that are viral-induced, such as invasive cervical cancer caused by the human papillomavirus (HPV). The aim of the study was to describe gynecological follow-up of women undergoing chronic immunosuppressive therapy for various reasons (e.g., kidney/liver transplant, systemic lupus erythematosus), diagnosed with a high-risk HPV (hrHPV) infection based on a self-sampling test. Twenty-six hrHPV-positive women were invited to take part in a gynecological follow-up, including a visual assessment of the anogenital region, two-handed gynecological examination, and cervical cytology as well as a colposcopy and cervical biopsy when necessary. Four women declined taking part in the study. Over six years of observation, low-grade squamous intraepithelial lesions (LSIL) were detected at least once in 7/22 women (31.8%), and a cervical intraepithelial lesion 1 (CIN 1) histopathologic result was obtained five times in 3/22 women. No cases of high-grade squamous intraepithelial lesions, CIN 2/3, or invasive cervical cancers were observed. Loop electrosurgical excision procedure (LEEP) was performed in three patients. As immunocompromised women are prone to persistent hrHPV infections, they should be under strict gynecological supervision because only vigilant surveillance enables fast detection and treatment of early dysplasia and, therefore, provides a chance for the reduction of the cervical cancer burden. MDPI 2022-03-16 /pmc/articles/PMC8953826/ /pubmed/35329222 http://dx.doi.org/10.3390/ijerph19063531 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wielgos, Aleksandra
Pietrzak, Bronisława
Suchonska, Barbara
Sikora, Mariusz
Rudnicka, Lidia
Wielgos, Miroslaw
A Six-Year Gynecological Follow-Up of Immunosuppressed Women with a High-Risk Human Papillomavirus Infection
title A Six-Year Gynecological Follow-Up of Immunosuppressed Women with a High-Risk Human Papillomavirus Infection
title_full A Six-Year Gynecological Follow-Up of Immunosuppressed Women with a High-Risk Human Papillomavirus Infection
title_fullStr A Six-Year Gynecological Follow-Up of Immunosuppressed Women with a High-Risk Human Papillomavirus Infection
title_full_unstemmed A Six-Year Gynecological Follow-Up of Immunosuppressed Women with a High-Risk Human Papillomavirus Infection
title_short A Six-Year Gynecological Follow-Up of Immunosuppressed Women with a High-Risk Human Papillomavirus Infection
title_sort six-year gynecological follow-up of immunosuppressed women with a high-risk human papillomavirus infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953826/
https://www.ncbi.nlm.nih.gov/pubmed/35329222
http://dx.doi.org/10.3390/ijerph19063531
work_keys_str_mv AT wielgosaleksandra asixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection
AT pietrzakbronisława asixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection
AT suchonskabarbara asixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection
AT sikoramariusz asixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection
AT rudnickalidia asixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection
AT wielgosmiroslaw asixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection
AT wielgosaleksandra sixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection
AT pietrzakbronisława sixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection
AT suchonskabarbara sixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection
AT sikoramariusz sixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection
AT rudnickalidia sixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection
AT wielgosmiroslaw sixyeargynecologicalfollowupofimmunosuppressedwomenwithahighriskhumanpapillomavirusinfection