Cargando…

Phenolics as GABA(A) Receptor Ligands: An Updated Review

Natural products can act as potential GABA modulators, avoiding the undesirable effects of traditional pharmacology used for the inhibition of the central nervous system such as benzodiazepines (BZD). Phenolics, especially flavonoids and phlorotannins, have been considered as modulators of the BZD-s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ríos, José-Luis, Schinella, Guillermo R., Moragrega, Inés
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953830/ https://www.ncbi.nlm.nih.gov/pubmed/35335130 http://dx.doi.org/10.3390/molecules27061770

Ejemplares similares

Flavonoids as GABA(A) receptor ligands: the whole story?
por: Wasowski, Cristina, et al.
Publicado: (2012)

An Update on GABAρ Receptors
por: Martínez-Delgado, Gustavo, et al.
Publicado: (2010)

The GABA(B) Receptor—Structure, Ligand Binding and Drug Development
por: Evenseth, Linn Samira Mari, et al.
Publicado: (2020)

GABA and the GABA(A) Receptor
por: Mihic, S. John, et al.
Publicado: (1997)

A Review of the Updated Pharmacophore for the Alpha 5 GABA(A) Benzodiazepine Receptor Model
por: Clayton, Terry, et al.
Publicado: (2015)

An update on control of brown spot of pear
por: Llorente, Isidre, et al.
Publicado: (2011)

Anti-Inflammatory and Antioxidant Chinese Herbal Medicines: Links between Traditional Characters and the Skin Lipoperoxidation “Western” Model
por: Prieto, Jose M., et al.
Publicado: (2022)

Ligand-guided homology modelling of the GABA(B2) subunit of the GABA(B) receptor
por: Freyd, Thibaud, et al.
Publicado: (2017)

Ionotropic GABA receptors: modelling and design of selective ligands
por: Palyulin, Vladimir A, et al.
Publicado: (2010)

Imaging GABA(c) Receptors with Ligand-Conjugated Quantum Dots
por: Tomlinson, Ian D., et al.
Publicado: (2007)

Structural mechanism of ligand activation in human GABA(B) receptor
por: Geng, Yong, et al.
Publicado: (2013)

The effect of GABA receptor ligands in experimental spina bifida occulta
por: Briner, Wayne
Publicado: (2001)

Electrophysiology of ionotropic GABA receptors
por: Sallard, Erwan, et al.
Publicado: (2021)

Modulation of Cox-1, 5-, 12- and 15-Lox by Popular Herbal Remedies Used in Southern Italy Against Psoriasis and Other Skin Diseases
por: Bader, Ammar, et al.
Publicado: (2015)

Versatility or Promiscuity: The Estrogen Receptors, Control of Ligand Selectivity and an Update on Subtype Selective Ligands
por: Ng, Hui Wen, et al.
Publicado: (2014)

Neuronal gamma-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA
por: Wang, Ping, et al.
Publicado: (2015)

The GABA and GABA-Receptor System in Inflammation, Anti-Tumor Immune Responses, and COVID-19
por: Tian, Jide, et al.
Publicado: (2023)

Diversity of structure and function of GABA(B) receptors: a complexity of GABA(B)-mediated signaling
por: TERUNUMA, Miho
Publicado: (2018)

The GABA receptors /
Publicado: (2007)

Allosteric Modulation of αβδ GABA(A) Receptors
por: Feng, Hua-Jun
Publicado: (2010)

GABA(B) receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence
por: Agabio, Roberta, et al.
Publicado: (2014)

Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABA(A) Receptor Activity
por: Jatczak-Śliwa, Magdalena, et al.
Publicado: (2018)

New GABA amides activating GABA(A)-receptors
por: Raster, Peter, et al.
Publicado: (2013)

Perisynaptic GABA Receptors The Overzealous Protector
por: Clarkson, Andrew N.
Publicado: (2012)

Antioxidant Activity and Cardioprotective Effect of a Nonalcoholic Extract of Vaccinium meridionale Swartz during Ischemia-Reperfusion in Rats
por: Lopera, Yasmin E., et al.
Publicado: (2013)

Molecular tools for GABA(A) receptors: High affinity ligands for β1-containing subtypes
por: Simeone, Xenia, et al.
Publicado: (2017)

Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation
por: McCarroll, Matthew N., et al.
Publicado: (2019)

Pharmacological Analysis of GABA(A) Receptor and Sigma1R Chaperone Interaction: Research Report I―Investigation of the Anxiolytic, Anticonvulsant and Hypnotic Effects of Allosteric GABA(A) Receptors’ Ligands
por: Voronin, Mikhail V., et al.
Publicado: (2023)

Molecular mechanisms of metabotropic GABA(B) receptor function
por: Shaye, Hamidreza, et al.
Publicado: (2021)

Metal-assisted synthesis of unsymmetrical magnolol and honokiol analogs and their biological assessment as GABA(A) receptor ligands
por: Rycek, Lukas, et al.
Publicado: (2015)

The Influence of AA29504 on GABA(A) Receptor Ligand Binding Properties and Its Implications on Subtype Selectivity
por: Sikstus, Sylvia, et al.
Publicado: (2021)

Benzodiazepine Modulation of GABA(A) Receptors: A Mechanistic Perspective
por: Goldschen-Ohm, Marcel P.
Publicado: (2022)

Pharmacological characterization of GABA(A) receptors in taurine-fed mice
por: L’Amoreaux, William J, et al.
Publicado: (2010)

Structure-Dependent Activity of Natural GABA(A) Receptor Modulators
por: Çiçek, Serhat Sezai
Publicado: (2018)

GABA(A) receptors: structure, function, pharmacology, and related disorders
por: Ghit, Amr, et al.
Publicado: (2021)

Significance of GABA(A) Receptor for Cognitive Function and Hippocampal Pathology
por: Sakimoto, Yuya, et al.
Publicado: (2021)

Mechanisms of GABA(B) receptor enhancement of extrasynaptic GABA(A) receptor currents in cerebellar granule cells
por: Khatri, Shailesh N., et al.
Publicado: (2019)

A Gut Feeling about GABA: Focus on GABA(B) Receptors
por: Hyland, Niall P., et al.
Publicado: (2010)

GABA Potency at GABA(A) Receptors Found in Synaptic and Extrasynaptic Zones
por: Mortensen, Martin, et al.
Publicado: (2012)

α subunits in GABA(A) receptors are dispensable for GABA and diazepam action
por: Wongsamitkul, Nisa, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_e8dtls8qslps2ogchf4rom5sml