A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases

Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present P...

Descripción completa

Detalles Bibliográficos
Autores principales: Konkolova, Eva, Krejčová, Kateřina, Eyer, Luděk, Hodek, Jan, Zgarbová, Michala, Fořtová, Andrea, Jirasek, Michael, Teply, Filip, Reyes-Gutierrez, Paul E., Růžek, Daniel, Weber, Jan, Boura, Evzen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953834/
https://www.ncbi.nlm.nih.gov/pubmed/35335258
http://dx.doi.org/10.3390/molecules27061894
Descripción
Sumario:Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many +RNA viruses are urgently needed. Here, we present PR673, a helquat-like compound that is able to inhibit the replication of SARS-CoV-2 and tick-borne encephalitis virus in cell culture. Using in vitro polymerase assays, we demonstrate that PR673 inhibits RNA synthesis by viral RNA-dependent RNA polymerases (RdRps). Our results illustrate that the development of broad-spectrum non-nucleoside inhibitors of RdRps is feasible.

Ejemplares similares