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Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials
INTRODUCTION: The development of the field related to the treatment of wounds has resulted in the appearance of new antimicrobial active ingredients. AIM: To analyse, evaluate and systematize the available scientific evidence of the effectiveness and safety of antiseptic preparations intended for th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953877/ https://www.ncbi.nlm.nih.gov/pubmed/35369629 http://dx.doi.org/10.5114/ada.2022.113807 |
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author | Cwajda-Białasik, Justyna Mościcka, Paulina Szewczyk, Maria T. |
author_facet | Cwajda-Białasik, Justyna Mościcka, Paulina Szewczyk, Maria T. |
author_sort | Cwajda-Białasik, Justyna |
collection | PubMed |
description | INTRODUCTION: The development of the field related to the treatment of wounds has resulted in the appearance of new antimicrobial active ingredients. AIM: To analyse, evaluate and systematize the available scientific evidence of the effectiveness and safety of antiseptic preparations intended for the treatment of chronic wounds. MATERIAL AND METHODS: We conducted a literature review using the advanced search engine in the PubMed database. We used a combination of two English keywords, i.e.: “antiseptic” and “chronic wound”. We have selected only clinical, randomized controlled trials. RESULTS: We obtained a total of 825 items (674 full-text works). We included 29 studies in the review. The most frequently evaluated preparation was octenidine dihydrochloride and povidone iodine (pharmacological drugs). Preparations containing polyhexanide, products based on hypochlorite, reactive oxygen species, 1% acetic acid, and specialized antibacterial dressings were also assessed. The new generation of antimicrobial preparations were highly effective, both in the prevention and treatment of infections, and were well tolerated by the tissues and do not interfere with the healing process. The best tolerated and most effective antiseptic was OCT/PE. For cleaning, we recommend OCT-based irrigation fluids, PHMB, or hypochlorite. The maintenance of the antimicrobial effect during the therapy was ensured by a compatible dressing. CONCLUSIONS: An antiseptic alone is not effective enough and the therapeutic effect depends to the greatest extent on properly selected causal therapy, preceded by thorough diagnostics. |
format | Online Article Text |
id | pubmed-8953877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-89538772022-03-31 Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials Cwajda-Białasik, Justyna Mościcka, Paulina Szewczyk, Maria T. Postepy Dermatol Alergol Original Paper INTRODUCTION: The development of the field related to the treatment of wounds has resulted in the appearance of new antimicrobial active ingredients. AIM: To analyse, evaluate and systematize the available scientific evidence of the effectiveness and safety of antiseptic preparations intended for the treatment of chronic wounds. MATERIAL AND METHODS: We conducted a literature review using the advanced search engine in the PubMed database. We used a combination of two English keywords, i.e.: “antiseptic” and “chronic wound”. We have selected only clinical, randomized controlled trials. RESULTS: We obtained a total of 825 items (674 full-text works). We included 29 studies in the review. The most frequently evaluated preparation was octenidine dihydrochloride and povidone iodine (pharmacological drugs). Preparations containing polyhexanide, products based on hypochlorite, reactive oxygen species, 1% acetic acid, and specialized antibacterial dressings were also assessed. The new generation of antimicrobial preparations were highly effective, both in the prevention and treatment of infections, and were well tolerated by the tissues and do not interfere with the healing process. The best tolerated and most effective antiseptic was OCT/PE. For cleaning, we recommend OCT-based irrigation fluids, PHMB, or hypochlorite. The maintenance of the antimicrobial effect during the therapy was ensured by a compatible dressing. CONCLUSIONS: An antiseptic alone is not effective enough and the therapeutic effect depends to the greatest extent on properly selected causal therapy, preceded by thorough diagnostics. Termedia Publishing House 2022-02-28 2022-02 /pmc/articles/PMC8953877/ /pubmed/35369629 http://dx.doi.org/10.5114/ada.2022.113807 Text en Copyright © 2022 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) ) |
spellingShingle | Original Paper Cwajda-Białasik, Justyna Mościcka, Paulina Szewczyk, Maria T. Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials |
title | Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials |
title_full | Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials |
title_fullStr | Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials |
title_full_unstemmed | Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials |
title_short | Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials |
title_sort | antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953877/ https://www.ncbi.nlm.nih.gov/pubmed/35369629 http://dx.doi.org/10.5114/ada.2022.113807 |
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