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Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials

INTRODUCTION: The development of the field related to the treatment of wounds has resulted in the appearance of new antimicrobial active ingredients. AIM: To analyse, evaluate and systematize the available scientific evidence of the effectiveness and safety of antiseptic preparations intended for th...

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Autores principales: Cwajda-Białasik, Justyna, Mościcka, Paulina, Szewczyk, Maria T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953877/
https://www.ncbi.nlm.nih.gov/pubmed/35369629
http://dx.doi.org/10.5114/ada.2022.113807
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author Cwajda-Białasik, Justyna
Mościcka, Paulina
Szewczyk, Maria T.
author_facet Cwajda-Białasik, Justyna
Mościcka, Paulina
Szewczyk, Maria T.
author_sort Cwajda-Białasik, Justyna
collection PubMed
description INTRODUCTION: The development of the field related to the treatment of wounds has resulted in the appearance of new antimicrobial active ingredients. AIM: To analyse, evaluate and systematize the available scientific evidence of the effectiveness and safety of antiseptic preparations intended for the treatment of chronic wounds. MATERIAL AND METHODS: We conducted a literature review using the advanced search engine in the PubMed database. We used a combination of two English keywords, i.e.: “antiseptic” and “chronic wound”. We have selected only clinical, randomized controlled trials. RESULTS: We obtained a total of 825 items (674 full-text works). We included 29 studies in the review. The most frequently evaluated preparation was octenidine dihydrochloride and povidone iodine (pharmacological drugs). Preparations containing polyhexanide, products based on hypochlorite, reactive oxygen species, 1% acetic acid, and specialized antibacterial dressings were also assessed. The new generation of antimicrobial preparations were highly effective, both in the prevention and treatment of infections, and were well tolerated by the tissues and do not interfere with the healing process. The best tolerated and most effective antiseptic was OCT/PE. For cleaning, we recommend OCT-based irrigation fluids, PHMB, or hypochlorite. The maintenance of the antimicrobial effect during the therapy was ensured by a compatible dressing. CONCLUSIONS: An antiseptic alone is not effective enough and the therapeutic effect depends to the greatest extent on properly selected causal therapy, preceded by thorough diagnostics.
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spelling pubmed-89538772022-03-31 Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials Cwajda-Białasik, Justyna Mościcka, Paulina Szewczyk, Maria T. Postepy Dermatol Alergol Original Paper INTRODUCTION: The development of the field related to the treatment of wounds has resulted in the appearance of new antimicrobial active ingredients. AIM: To analyse, evaluate and systematize the available scientific evidence of the effectiveness and safety of antiseptic preparations intended for the treatment of chronic wounds. MATERIAL AND METHODS: We conducted a literature review using the advanced search engine in the PubMed database. We used a combination of two English keywords, i.e.: “antiseptic” and “chronic wound”. We have selected only clinical, randomized controlled trials. RESULTS: We obtained a total of 825 items (674 full-text works). We included 29 studies in the review. The most frequently evaluated preparation was octenidine dihydrochloride and povidone iodine (pharmacological drugs). Preparations containing polyhexanide, products based on hypochlorite, reactive oxygen species, 1% acetic acid, and specialized antibacterial dressings were also assessed. The new generation of antimicrobial preparations were highly effective, both in the prevention and treatment of infections, and were well tolerated by the tissues and do not interfere with the healing process. The best tolerated and most effective antiseptic was OCT/PE. For cleaning, we recommend OCT-based irrigation fluids, PHMB, or hypochlorite. The maintenance of the antimicrobial effect during the therapy was ensured by a compatible dressing. CONCLUSIONS: An antiseptic alone is not effective enough and the therapeutic effect depends to the greatest extent on properly selected causal therapy, preceded by thorough diagnostics. Termedia Publishing House 2022-02-28 2022-02 /pmc/articles/PMC8953877/ /pubmed/35369629 http://dx.doi.org/10.5114/ada.2022.113807 Text en Copyright © 2022 Termedia https://creativecommons.org/licenses/by-nc-sa/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/) )
spellingShingle Original Paper
Cwajda-Białasik, Justyna
Mościcka, Paulina
Szewczyk, Maria T.
Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials
title Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials
title_full Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials
title_fullStr Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials
title_full_unstemmed Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials
title_short Antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials
title_sort antiseptics and antimicrobials for the treatment and management of chronic wounds: a systematic review of clinical trials
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953877/
https://www.ncbi.nlm.nih.gov/pubmed/35369629
http://dx.doi.org/10.5114/ada.2022.113807
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