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Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19

The cell surface serine protease Transmembrane Protease 2 (TMPRSS2) is required to cleave the spike protein of SARS-CoV-2 for viral entry into cells. We determined whether negatively-charged heparin enhanced TMPRSS2 inhibition by alpha-1-antitrypsin (AAT). TMPRSS2 activity was determined in HEK293T...

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Detalles Bibliográficos
Autores principales:	Bai, Xiyuan, Buckle, Ashley M., Vladar, Eszter K., Janoff, Edward N., Khare, Reeti, Ordway, Diane, Beckham, David, Fornis, Lorelenn B., Majluf-Cruz, Abraham, Fugit, Randolph V., Freed, Brian M., Kim, Soohyun, Sandhaus, Robert A., Chan, Edward D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953970/ https://www.ncbi.nlm.nih.gov/pubmed/35338216 http://dx.doi.org/10.1038/s41598-022-09133-9

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