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Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility?

The purpose of this study was to compare the frequency of COL1A1 rs1107946 polymorphism between sport climbers and controls from three ethnic groups (Japanese, Polish, and Russian) and investigate the effect of the COL1A1 rs1107946 polymorphism on the age-related decrease in flexibility in the gener...

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Autores principales: Saito, Mika, Ginszt, Michał, Semenova, Ekaterina A., Massidda, Myosotis, Huminska-Lisowska, Kinga, Michałowska-Sawczyn, Monika, Homma, Hiroki, Cięszczyk, Paweł, Okamoto, Takanobu, Larin, Andrey K., Generozov, Edward V., Majcher, Piotr, Nakazato, Koichi, Ahmetov, Ildus I., Kikuchi, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954011/
https://www.ncbi.nlm.nih.gov/pubmed/35327955
http://dx.doi.org/10.3390/genes13030403
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author Saito, Mika
Ginszt, Michał
Semenova, Ekaterina A.
Massidda, Myosotis
Huminska-Lisowska, Kinga
Michałowska-Sawczyn, Monika
Homma, Hiroki
Cięszczyk, Paweł
Okamoto, Takanobu
Larin, Andrey K.
Generozov, Edward V.
Majcher, Piotr
Nakazato, Koichi
Ahmetov, Ildus I.
Kikuchi, Naoki
author_facet Saito, Mika
Ginszt, Michał
Semenova, Ekaterina A.
Massidda, Myosotis
Huminska-Lisowska, Kinga
Michałowska-Sawczyn, Monika
Homma, Hiroki
Cięszczyk, Paweł
Okamoto, Takanobu
Larin, Andrey K.
Generozov, Edward V.
Majcher, Piotr
Nakazato, Koichi
Ahmetov, Ildus I.
Kikuchi, Naoki
author_sort Saito, Mika
collection PubMed
description The purpose of this study was to compare the frequency of COL1A1 rs1107946 polymorphism between sport climbers and controls from three ethnic groups (Japanese, Polish, and Russian) and investigate the effect of the COL1A1 rs1107946 polymorphism on the age-related decrease in flexibility in the general population. Study I consisted of 1929 healthy people (controls) and 218 climbers, including Japanese, Polish, and Russian participants. The results of the meta-analysis showed that the frequency of the AC genotype was higher in climbers than in the controls (p = 0.03). Study II involved 1093 healthy Japanese individuals (435 men and 658 women). Flexibility was assessed using a sit-and-reach test. There was a tendency towards association between sit-and-reach and the COL1A1 rs1107946 polymorphism (genotype: p = 0.034; dominant: p = 0.435; recessive: p = 0.035; over-dominant: p = 0.026). In addition, there was a higher negative correlation between sit-and-reach and age in the AA + CC genotype than in the AC genotype (AA + CC: r = −0.216, p < 0.001; AC: r = −0.089, p = 0.04; interaction p = 0.037). However, none of these results survived correction for multiple testing. Further studies are warranted to investigate the association between the COL1A1 gene variation and exercise-related phenotypes.
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spelling pubmed-89540112022-03-26 Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility? Saito, Mika Ginszt, Michał Semenova, Ekaterina A. Massidda, Myosotis Huminska-Lisowska, Kinga Michałowska-Sawczyn, Monika Homma, Hiroki Cięszczyk, Paweł Okamoto, Takanobu Larin, Andrey K. Generozov, Edward V. Majcher, Piotr Nakazato, Koichi Ahmetov, Ildus I. Kikuchi, Naoki Genes (Basel) Article The purpose of this study was to compare the frequency of COL1A1 rs1107946 polymorphism between sport climbers and controls from three ethnic groups (Japanese, Polish, and Russian) and investigate the effect of the COL1A1 rs1107946 polymorphism on the age-related decrease in flexibility in the general population. Study I consisted of 1929 healthy people (controls) and 218 climbers, including Japanese, Polish, and Russian participants. The results of the meta-analysis showed that the frequency of the AC genotype was higher in climbers than in the controls (p = 0.03). Study II involved 1093 healthy Japanese individuals (435 men and 658 women). Flexibility was assessed using a sit-and-reach test. There was a tendency towards association between sit-and-reach and the COL1A1 rs1107946 polymorphism (genotype: p = 0.034; dominant: p = 0.435; recessive: p = 0.035; over-dominant: p = 0.026). In addition, there was a higher negative correlation between sit-and-reach and age in the AA + CC genotype than in the AC genotype (AA + CC: r = −0.216, p < 0.001; AC: r = −0.089, p = 0.04; interaction p = 0.037). However, none of these results survived correction for multiple testing. Further studies are warranted to investigate the association between the COL1A1 gene variation and exercise-related phenotypes. MDPI 2022-02-23 /pmc/articles/PMC8954011/ /pubmed/35327955 http://dx.doi.org/10.3390/genes13030403 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Saito, Mika
Ginszt, Michał
Semenova, Ekaterina A.
Massidda, Myosotis
Huminska-Lisowska, Kinga
Michałowska-Sawczyn, Monika
Homma, Hiroki
Cięszczyk, Paweł
Okamoto, Takanobu
Larin, Andrey K.
Generozov, Edward V.
Majcher, Piotr
Nakazato, Koichi
Ahmetov, Ildus I.
Kikuchi, Naoki
Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility?
title Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility?
title_full Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility?
title_fullStr Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility?
title_full_unstemmed Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility?
title_short Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility?
title_sort is col1a1 gene rs1107946 polymorphism associated with sport climbing status and flexibility?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954011/
https://www.ncbi.nlm.nih.gov/pubmed/35327955
http://dx.doi.org/10.3390/genes13030403
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