Cargando…
Typing of the Gut Microbiota Community in Japanese Subjects
Gut microbiota are involved in both host health and disease and can be stratified based on bacteriological composition. However, gut microbiota clustering data are limited for Asians. In this study, fecal microbiota of 1803 Japanese subjects, including 283 healthy individuals, were analyzed by 16S r...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954045/ https://www.ncbi.nlm.nih.gov/pubmed/35336239 http://dx.doi.org/10.3390/microorganisms10030664 |
_version_ | 1784675996961603584 |
---|---|
author | Takagi, Tomohisa Inoue, Ryo Oshima, Akira Sakazume, Hiroshi Ogawa, Kenta Tominaga, Tomo Mihara, Yoichi Sugaya, Takeshi Mizushima, Katsura Uchiyama, Kazuhiko Itoh, Yoshito Naito, Yuji |
author_facet | Takagi, Tomohisa Inoue, Ryo Oshima, Akira Sakazume, Hiroshi Ogawa, Kenta Tominaga, Tomo Mihara, Yoichi Sugaya, Takeshi Mizushima, Katsura Uchiyama, Kazuhiko Itoh, Yoshito Naito, Yuji |
author_sort | Takagi, Tomohisa |
collection | PubMed |
description | Gut microbiota are involved in both host health and disease and can be stratified based on bacteriological composition. However, gut microbiota clustering data are limited for Asians. In this study, fecal microbiota of 1803 Japanese subjects, including 283 healthy individuals, were analyzed by 16S rRNA sequencing and clustered using two models. The association of various diseases with each community type was also assessed. Five and fifteen communities were identified using partitioning around medoids (PAM) and the Dirichlet multinominal mixtures model, respectively. Bacteria exhibiting characteristically high abundance among the PAM-identified types were of the family Ruminococcaceae (Type A) and genera Bacteroides, Blautia, and Faecalibacterium (Type B); Bacteroides, Fusobacterium, and Proteus (Type C); and Bifidobacterium (Type D), and Prevotella (Type E). The most noteworthy community found in the Japanese subjects was the Bifidobacterium-rich community. The odds ratio based on type E, which had the largest population of healthy subjects, revealed that other types (especially types A, C, and D) were highly associated with various diseases, including inflammatory bowel disease, functional gastrointestinal disorder, and lifestyle-related diseases. Gut microbiota community typing reproducibly identified organisms that may represent enterotypes peculiar to Japanese individuals and that are partly different from those of indivuals from Western countries. |
format | Online Article Text |
id | pubmed-8954045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89540452022-03-26 Typing of the Gut Microbiota Community in Japanese Subjects Takagi, Tomohisa Inoue, Ryo Oshima, Akira Sakazume, Hiroshi Ogawa, Kenta Tominaga, Tomo Mihara, Yoichi Sugaya, Takeshi Mizushima, Katsura Uchiyama, Kazuhiko Itoh, Yoshito Naito, Yuji Microorganisms Article Gut microbiota are involved in both host health and disease and can be stratified based on bacteriological composition. However, gut microbiota clustering data are limited for Asians. In this study, fecal microbiota of 1803 Japanese subjects, including 283 healthy individuals, were analyzed by 16S rRNA sequencing and clustered using two models. The association of various diseases with each community type was also assessed. Five and fifteen communities were identified using partitioning around medoids (PAM) and the Dirichlet multinominal mixtures model, respectively. Bacteria exhibiting characteristically high abundance among the PAM-identified types were of the family Ruminococcaceae (Type A) and genera Bacteroides, Blautia, and Faecalibacterium (Type B); Bacteroides, Fusobacterium, and Proteus (Type C); and Bifidobacterium (Type D), and Prevotella (Type E). The most noteworthy community found in the Japanese subjects was the Bifidobacterium-rich community. The odds ratio based on type E, which had the largest population of healthy subjects, revealed that other types (especially types A, C, and D) were highly associated with various diseases, including inflammatory bowel disease, functional gastrointestinal disorder, and lifestyle-related diseases. Gut microbiota community typing reproducibly identified organisms that may represent enterotypes peculiar to Japanese individuals and that are partly different from those of indivuals from Western countries. MDPI 2022-03-20 /pmc/articles/PMC8954045/ /pubmed/35336239 http://dx.doi.org/10.3390/microorganisms10030664 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Takagi, Tomohisa Inoue, Ryo Oshima, Akira Sakazume, Hiroshi Ogawa, Kenta Tominaga, Tomo Mihara, Yoichi Sugaya, Takeshi Mizushima, Katsura Uchiyama, Kazuhiko Itoh, Yoshito Naito, Yuji Typing of the Gut Microbiota Community in Japanese Subjects |
title | Typing of the Gut Microbiota Community in Japanese Subjects |
title_full | Typing of the Gut Microbiota Community in Japanese Subjects |
title_fullStr | Typing of the Gut Microbiota Community in Japanese Subjects |
title_full_unstemmed | Typing of the Gut Microbiota Community in Japanese Subjects |
title_short | Typing of the Gut Microbiota Community in Japanese Subjects |
title_sort | typing of the gut microbiota community in japanese subjects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954045/ https://www.ncbi.nlm.nih.gov/pubmed/35336239 http://dx.doi.org/10.3390/microorganisms10030664 |
work_keys_str_mv | AT takagitomohisa typingofthegutmicrobiotacommunityinjapanesesubjects AT inoueryo typingofthegutmicrobiotacommunityinjapanesesubjects AT oshimaakira typingofthegutmicrobiotacommunityinjapanesesubjects AT sakazumehiroshi typingofthegutmicrobiotacommunityinjapanesesubjects AT ogawakenta typingofthegutmicrobiotacommunityinjapanesesubjects AT tominagatomo typingofthegutmicrobiotacommunityinjapanesesubjects AT miharayoichi typingofthegutmicrobiotacommunityinjapanesesubjects AT sugayatakeshi typingofthegutmicrobiotacommunityinjapanesesubjects AT mizushimakatsura typingofthegutmicrobiotacommunityinjapanesesubjects AT uchiyamakazuhiko typingofthegutmicrobiotacommunityinjapanesesubjects AT itohyoshito typingofthegutmicrobiotacommunityinjapanesesubjects AT naitoyuji typingofthegutmicrobiotacommunityinjapanesesubjects |