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Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity

Euphormin-A (1) and euphormin-B (2), two new pyranocoumarin derivatives, and forty known compounds (3–42) were isolated from Euphorbia formosana Hayata (Euphorbiaceae). The chemical structures of all compounds were established based on spectroscopic analyses. Several isolates were evaluated for thei...

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Autores principales: Lan, Yu-Hsuan, Chen, I-Hsiao, Lu, Hsin-Hung, Guo, Ting-Jing, Hwang, Tsong-Long, Leu, Yann-Lii
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954059/
https://www.ncbi.nlm.nih.gov/pubmed/35335252
http://dx.doi.org/10.3390/molecules27061885
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author Lan, Yu-Hsuan
Chen, I-Hsiao
Lu, Hsin-Hung
Guo, Ting-Jing
Hwang, Tsong-Long
Leu, Yann-Lii
author_facet Lan, Yu-Hsuan
Chen, I-Hsiao
Lu, Hsin-Hung
Guo, Ting-Jing
Hwang, Tsong-Long
Leu, Yann-Lii
author_sort Lan, Yu-Hsuan
collection PubMed
description Euphormin-A (1) and euphormin-B (2), two new pyranocoumarin derivatives, and forty known compounds (3–42) were isolated from Euphorbia formosana Hayata (Euphorbiaceae). The chemical structures of all compounds were established based on spectroscopic analyses. Several isolates were evaluated for their anti-inflammatory activity. Compounds 1, 2, 10, 18, 25, and 33 significantly inhibited against superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Furthermore, compounds 25 and 33 displayed the most potent effects with IC(50) values of 0.68 ± 0.18 and 1.39 ± 0.12 µM, respectively, against superoxide anion generation when compared with the positive control (2.01 ± 0.06 µM).
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spelling pubmed-89540592022-03-26 Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity Lan, Yu-Hsuan Chen, I-Hsiao Lu, Hsin-Hung Guo, Ting-Jing Hwang, Tsong-Long Leu, Yann-Lii Molecules Article Euphormin-A (1) and euphormin-B (2), two new pyranocoumarin derivatives, and forty known compounds (3–42) were isolated from Euphorbia formosana Hayata (Euphorbiaceae). The chemical structures of all compounds were established based on spectroscopic analyses. Several isolates were evaluated for their anti-inflammatory activity. Compounds 1, 2, 10, 18, 25, and 33 significantly inhibited against superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Furthermore, compounds 25 and 33 displayed the most potent effects with IC(50) values of 0.68 ± 0.18 and 1.39 ± 0.12 µM, respectively, against superoxide anion generation when compared with the positive control (2.01 ± 0.06 µM). MDPI 2022-03-14 /pmc/articles/PMC8954059/ /pubmed/35335252 http://dx.doi.org/10.3390/molecules27061885 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lan, Yu-Hsuan
Chen, I-Hsiao
Lu, Hsin-Hung
Guo, Ting-Jing
Hwang, Tsong-Long
Leu, Yann-Lii
Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity
title Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity
title_full Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity
title_fullStr Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity
title_full_unstemmed Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity
title_short Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity
title_sort euphormins a and b, new pyranocoumarin derivatives from euphorbia formosana hayata, and their anti-inflammatory activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954059/
https://www.ncbi.nlm.nih.gov/pubmed/35335252
http://dx.doi.org/10.3390/molecules27061885
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