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Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring

Optical fiber technology has rapidly progressed over the years, providing valuable benefits for biosensing purposes such as sensor miniaturization and the possibility for remote and real-time monitoring. In particular, tilted fiber Bragg gratings (TFBGs) are extremely sensitive to refractive index v...

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Autores principales: Vidal, Miguel, Soares, Maria Simone, Loyez, Médéric, Costa, Florinda M., Caucheteur, Christophe, Marques, Carlos, Pereira, Sónia O., Leitão, Cátia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954114/
https://www.ncbi.nlm.nih.gov/pubmed/35336312
http://dx.doi.org/10.3390/s22062141
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author Vidal, Miguel
Soares, Maria Simone
Loyez, Médéric
Costa, Florinda M.
Caucheteur, Christophe
Marques, Carlos
Pereira, Sónia O.
Leitão, Cátia
author_facet Vidal, Miguel
Soares, Maria Simone
Loyez, Médéric
Costa, Florinda M.
Caucheteur, Christophe
Marques, Carlos
Pereira, Sónia O.
Leitão, Cátia
author_sort Vidal, Miguel
collection PubMed
description Optical fiber technology has rapidly progressed over the years, providing valuable benefits for biosensing purposes such as sensor miniaturization and the possibility for remote and real-time monitoring. In particular, tilted fiber Bragg gratings (TFBGs) are extremely sensitive to refractive index variations taking place on their surface. The present work comprises a case-study on the impact of different methods of analysis applied to decode spectral variations of bare and plasmonic TFBGs during the detection of N-terminal B-type natriuretic peptide (NT-proBNP), a heart failure biomarker, namely by following the most sensitive mode, peaks of the spectral envelopes, and the envelopes’ crossing point and area. Tracking the lower envelope resulted in the lowest limits of detection (LOD) for bare and plasmonic TFBGs, namely, 0.75 ng/mL and 0.19 ng/mL, respectively. This work demonstrates the importance of the analysis method on the outcome results, which is crucial to attain the most reliable and sensitive method with lower LOD sensors. Furthermore, it makes the scientific community aware to take careful attention when comparing the performance of different biosensors in which different analysis methods were used.
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spelling pubmed-89541142022-03-26 Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring Vidal, Miguel Soares, Maria Simone Loyez, Médéric Costa, Florinda M. Caucheteur, Christophe Marques, Carlos Pereira, Sónia O. Leitão, Cátia Sensors (Basel) Article Optical fiber technology has rapidly progressed over the years, providing valuable benefits for biosensing purposes such as sensor miniaturization and the possibility for remote and real-time monitoring. In particular, tilted fiber Bragg gratings (TFBGs) are extremely sensitive to refractive index variations taking place on their surface. The present work comprises a case-study on the impact of different methods of analysis applied to decode spectral variations of bare and plasmonic TFBGs during the detection of N-terminal B-type natriuretic peptide (NT-proBNP), a heart failure biomarker, namely by following the most sensitive mode, peaks of the spectral envelopes, and the envelopes’ crossing point and area. Tracking the lower envelope resulted in the lowest limits of detection (LOD) for bare and plasmonic TFBGs, namely, 0.75 ng/mL and 0.19 ng/mL, respectively. This work demonstrates the importance of the analysis method on the outcome results, which is crucial to attain the most reliable and sensitive method with lower LOD sensors. Furthermore, it makes the scientific community aware to take careful attention when comparing the performance of different biosensors in which different analysis methods were used. MDPI 2022-03-10 /pmc/articles/PMC8954114/ /pubmed/35336312 http://dx.doi.org/10.3390/s22062141 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vidal, Miguel
Soares, Maria Simone
Loyez, Médéric
Costa, Florinda M.
Caucheteur, Christophe
Marques, Carlos
Pereira, Sónia O.
Leitão, Cátia
Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring
title Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring
title_full Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring
title_fullStr Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring
title_full_unstemmed Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring
title_short Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring
title_sort relevance of the spectral analysis method of tilted fiber bragg grating-based biosensors: a case-study for heart failure monitoring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954114/
https://www.ncbi.nlm.nih.gov/pubmed/35336312
http://dx.doi.org/10.3390/s22062141
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