Cargando…

Creating Acceptable Tablets 3D (CAT 3D): A Feasibility Study to Evaluate the Acceptability of 3D Printed Tablets in Children and Young People

3D printing (3DP) has been proposed as a novel approach for personalising dosage forms for children and young people (CYP). Owing to its low cost and the lack of need for finishing steps, fused deposing modelling (FDM) 3DP has been heavily researched in solid dosage forms (SDFs) manufacturing. Howev...

Descripción completa

Detalles Bibliográficos
Autores principales: Bracken, Louise, Habashy, Rober, McDonough, Emma, Wilson, Fiona, Shakeshaft, Joanne, Ohia, Udeme, Garcia-Sorribes, Tamar, Isreb, Abdullah, Alhnan, Mohamed A., Peak, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954179/
https://www.ncbi.nlm.nih.gov/pubmed/35335892
http://dx.doi.org/10.3390/pharmaceutics14030516
_version_ 1784676031017254912
author Bracken, Louise
Habashy, Rober
McDonough, Emma
Wilson, Fiona
Shakeshaft, Joanne
Ohia, Udeme
Garcia-Sorribes, Tamar
Isreb, Abdullah
Alhnan, Mohamed A.
Peak, Matthew
author_facet Bracken, Louise
Habashy, Rober
McDonough, Emma
Wilson, Fiona
Shakeshaft, Joanne
Ohia, Udeme
Garcia-Sorribes, Tamar
Isreb, Abdullah
Alhnan, Mohamed A.
Peak, Matthew
author_sort Bracken, Louise
collection PubMed
description 3D printing (3DP) has been proposed as a novel approach for personalising dosage forms for children and young people (CYP). Owing to its low cost and the lack of need for finishing steps, fused deposing modelling (FDM) 3DP has been heavily researched in solid dosage forms (SDFs) manufacturing. However, the swallowability and overall acceptability of 3D printed dosage forms are yet to be established. This work is the first to evaluate the acceptability of different sized 3D printed placebo SDFs in CYP (aged 4–12 years). All participants had previously participated in a feasibility study (CAT study) that assessed the swallowability and acceptability of different sized GMP manufactured placebo conventional film-coated tablets, and therefore only attempted to swallow one 3D printed tablet. The participants assessed the swallowability, acceptability, mouthfeel, volume of water consumed, and taste of the sample using a 5-point hedonic facial scale on a participant questionnaire. A total of 30 participants were recruited, 87% of whom successfully swallowed the 3D printed tablet that they attempted to take. Attributes of the 3D printed tablets were scored as acceptable by the following percentage of participants—swallowability (80%), mouthfeel/texture (87%), the volume of water consumed (80%), taste (93%), and overall acceptability (83%). Overall, 77% of children reported they would be happy to take the tablet every day if it was a medicine. Participants were also asked which tablets felt better in the mouth—the film-coated tablets or the 3D printed tablets, and the most popular response (43%) was that both were acceptable. This study shows that FDM-based 3D printed SDFs may be a suitable dosage form for children aged 4–12 years. The results from this feasibility study will be used to inform a larger, definitive study looking at the acceptability of 3D printed tablets in children.
format Online
Article
Text
id pubmed-8954179
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89541792022-03-26 Creating Acceptable Tablets 3D (CAT 3D): A Feasibility Study to Evaluate the Acceptability of 3D Printed Tablets in Children and Young People Bracken, Louise Habashy, Rober McDonough, Emma Wilson, Fiona Shakeshaft, Joanne Ohia, Udeme Garcia-Sorribes, Tamar Isreb, Abdullah Alhnan, Mohamed A. Peak, Matthew Pharmaceutics Article 3D printing (3DP) has been proposed as a novel approach for personalising dosage forms for children and young people (CYP). Owing to its low cost and the lack of need for finishing steps, fused deposing modelling (FDM) 3DP has been heavily researched in solid dosage forms (SDFs) manufacturing. However, the swallowability and overall acceptability of 3D printed dosage forms are yet to be established. This work is the first to evaluate the acceptability of different sized 3D printed placebo SDFs in CYP (aged 4–12 years). All participants had previously participated in a feasibility study (CAT study) that assessed the swallowability and acceptability of different sized GMP manufactured placebo conventional film-coated tablets, and therefore only attempted to swallow one 3D printed tablet. The participants assessed the swallowability, acceptability, mouthfeel, volume of water consumed, and taste of the sample using a 5-point hedonic facial scale on a participant questionnaire. A total of 30 participants were recruited, 87% of whom successfully swallowed the 3D printed tablet that they attempted to take. Attributes of the 3D printed tablets were scored as acceptable by the following percentage of participants—swallowability (80%), mouthfeel/texture (87%), the volume of water consumed (80%), taste (93%), and overall acceptability (83%). Overall, 77% of children reported they would be happy to take the tablet every day if it was a medicine. Participants were also asked which tablets felt better in the mouth—the film-coated tablets or the 3D printed tablets, and the most popular response (43%) was that both were acceptable. This study shows that FDM-based 3D printed SDFs may be a suitable dosage form for children aged 4–12 years. The results from this feasibility study will be used to inform a larger, definitive study looking at the acceptability of 3D printed tablets in children. MDPI 2022-02-25 /pmc/articles/PMC8954179/ /pubmed/35335892 http://dx.doi.org/10.3390/pharmaceutics14030516 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bracken, Louise
Habashy, Rober
McDonough, Emma
Wilson, Fiona
Shakeshaft, Joanne
Ohia, Udeme
Garcia-Sorribes, Tamar
Isreb, Abdullah
Alhnan, Mohamed A.
Peak, Matthew
Creating Acceptable Tablets 3D (CAT 3D): A Feasibility Study to Evaluate the Acceptability of 3D Printed Tablets in Children and Young People
title Creating Acceptable Tablets 3D (CAT 3D): A Feasibility Study to Evaluate the Acceptability of 3D Printed Tablets in Children and Young People
title_full Creating Acceptable Tablets 3D (CAT 3D): A Feasibility Study to Evaluate the Acceptability of 3D Printed Tablets in Children and Young People
title_fullStr Creating Acceptable Tablets 3D (CAT 3D): A Feasibility Study to Evaluate the Acceptability of 3D Printed Tablets in Children and Young People
title_full_unstemmed Creating Acceptable Tablets 3D (CAT 3D): A Feasibility Study to Evaluate the Acceptability of 3D Printed Tablets in Children and Young People
title_short Creating Acceptable Tablets 3D (CAT 3D): A Feasibility Study to Evaluate the Acceptability of 3D Printed Tablets in Children and Young People
title_sort creating acceptable tablets 3d (cat 3d): a feasibility study to evaluate the acceptability of 3d printed tablets in children and young people
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954179/
https://www.ncbi.nlm.nih.gov/pubmed/35335892
http://dx.doi.org/10.3390/pharmaceutics14030516
work_keys_str_mv AT brackenlouise creatingacceptabletablets3dcat3dafeasibilitystudytoevaluatetheacceptabilityof3dprintedtabletsinchildrenandyoungpeople
AT habashyrober creatingacceptabletablets3dcat3dafeasibilitystudytoevaluatetheacceptabilityof3dprintedtabletsinchildrenandyoungpeople
AT mcdonoughemma creatingacceptabletablets3dcat3dafeasibilitystudytoevaluatetheacceptabilityof3dprintedtabletsinchildrenandyoungpeople
AT wilsonfiona creatingacceptabletablets3dcat3dafeasibilitystudytoevaluatetheacceptabilityof3dprintedtabletsinchildrenandyoungpeople
AT shakeshaftjoanne creatingacceptabletablets3dcat3dafeasibilitystudytoevaluatetheacceptabilityof3dprintedtabletsinchildrenandyoungpeople
AT ohiaudeme creatingacceptabletablets3dcat3dafeasibilitystudytoevaluatetheacceptabilityof3dprintedtabletsinchildrenandyoungpeople
AT garciasorribestamar creatingacceptabletablets3dcat3dafeasibilitystudytoevaluatetheacceptabilityof3dprintedtabletsinchildrenandyoungpeople
AT isrebabdullah creatingacceptabletablets3dcat3dafeasibilitystudytoevaluatetheacceptabilityof3dprintedtabletsinchildrenandyoungpeople
AT alhnanmohameda creatingacceptabletablets3dcat3dafeasibilitystudytoevaluatetheacceptabilityof3dprintedtabletsinchildrenandyoungpeople
AT peakmatthew creatingacceptabletablets3dcat3dafeasibilitystudytoevaluatetheacceptabilityof3dprintedtabletsinchildrenandyoungpeople