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Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954190/ https://www.ncbi.nlm.nih.gov/pubmed/35334878 http://dx.doi.org/10.3390/nu14061221 |
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author | Manzano, Mónica Talavera-Rodríguez, Alba Moreno, Elena Madrid, Nadia Gosalbes, María José Ron, Raquel Dronda, Fernando Pérez-Molina, José A. Lanza, Val F. Díaz, Jorge Moreno, Santiago Navia, Beatriz Serrano-Villar, Sergio |
author_facet | Manzano, Mónica Talavera-Rodríguez, Alba Moreno, Elena Madrid, Nadia Gosalbes, María José Ron, Raquel Dronda, Fernando Pérez-Molina, José A. Lanza, Val F. Díaz, Jorge Moreno, Santiago Navia, Beatriz Serrano-Villar, Sergio |
author_sort | Manzano, Mónica |
collection | PubMed |
description | While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation. |
format | Online Article Text |
id | pubmed-8954190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89541902022-03-26 Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV Manzano, Mónica Talavera-Rodríguez, Alba Moreno, Elena Madrid, Nadia Gosalbes, María José Ron, Raquel Dronda, Fernando Pérez-Molina, José A. Lanza, Val F. Díaz, Jorge Moreno, Santiago Navia, Beatriz Serrano-Villar, Sergio Nutrients Article While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation. MDPI 2022-03-14 /pmc/articles/PMC8954190/ /pubmed/35334878 http://dx.doi.org/10.3390/nu14061221 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Manzano, Mónica Talavera-Rodríguez, Alba Moreno, Elena Madrid, Nadia Gosalbes, María José Ron, Raquel Dronda, Fernando Pérez-Molina, José A. Lanza, Val F. Díaz, Jorge Moreno, Santiago Navia, Beatriz Serrano-Villar, Sergio Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV |
title | Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV |
title_full | Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV |
title_fullStr | Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV |
title_full_unstemmed | Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV |
title_short | Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV |
title_sort | relationship of diet to gut microbiota and inflammatory biomarkers in people with hiv |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954190/ https://www.ncbi.nlm.nih.gov/pubmed/35334878 http://dx.doi.org/10.3390/nu14061221 |
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