Cargando…

Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV

While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two...

Descripción completa

Detalles Bibliográficos
Autores principales: Manzano, Mónica, Talavera-Rodríguez, Alba, Moreno, Elena, Madrid, Nadia, Gosalbes, María José, Ron, Raquel, Dronda, Fernando, Pérez-Molina, José A., Lanza, Val F., Díaz, Jorge, Moreno, Santiago, Navia, Beatriz, Serrano-Villar, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954190/
https://www.ncbi.nlm.nih.gov/pubmed/35334878
http://dx.doi.org/10.3390/nu14061221
_version_ 1784676033740406784
author Manzano, Mónica
Talavera-Rodríguez, Alba
Moreno, Elena
Madrid, Nadia
Gosalbes, María José
Ron, Raquel
Dronda, Fernando
Pérez-Molina, José A.
Lanza, Val F.
Díaz, Jorge
Moreno, Santiago
Navia, Beatriz
Serrano-Villar, Sergio
author_facet Manzano, Mónica
Talavera-Rodríguez, Alba
Moreno, Elena
Madrid, Nadia
Gosalbes, María José
Ron, Raquel
Dronda, Fernando
Pérez-Molina, José A.
Lanza, Val F.
Díaz, Jorge
Moreno, Santiago
Navia, Beatriz
Serrano-Villar, Sergio
author_sort Manzano, Mónica
collection PubMed
description While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation.
format Online
Article
Text
id pubmed-8954190
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-89541902022-03-26 Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV Manzano, Mónica Talavera-Rodríguez, Alba Moreno, Elena Madrid, Nadia Gosalbes, María José Ron, Raquel Dronda, Fernando Pérez-Molina, José A. Lanza, Val F. Díaz, Jorge Moreno, Santiago Navia, Beatriz Serrano-Villar, Sergio Nutrients Article While changes in microbiome composition have been associated with HIV, the effect of diet and its potential impact on inflammation remains unclear. Methods: Twenty-seven people living with HIV (PWH) on antiretroviral therapy (ART) were studied. A comprehensive dietary analysis was performed and two types of dietary patterns were determined. We explored the associations of each dietary pattern with gut microbiota and plasma inflammatory biomarkers. Results: We appreciated two dietary patterns, Mediterranean-like (MEL) and one Western-like (WEL). Compared to participants with the WEL pattern, participants with MEL pattern showed higher abundance of Lachnospira (p-value = 0.02) and lower levels of the inflammatory biomarkers D-dimer (p-value = 0.050) and soluble TNF-alpha receptor 2 (sTNFR2) (p-value = 0.049). Men who have sex with men (MSM) with MEL pattern had lower abundance of Erysipelotrichaceae (p-value < 0.001) and lower levels of D-dimer (p-value = 0.026) than MSM with WEL pattern. Conclusion: MEL pattern favours Lachnospira abundance, and protects against Erysipelotrichaceae abundance and higher levels of the inflammatory biomarkers D-dimer and sTNFR2, precursors of inflammatory processes in HIV-infected patients. Our study contributes to understanding the determinants of a healthier diet and its connections with gut microbiota and inflammation. MDPI 2022-03-14 /pmc/articles/PMC8954190/ /pubmed/35334878 http://dx.doi.org/10.3390/nu14061221 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manzano, Mónica
Talavera-Rodríguez, Alba
Moreno, Elena
Madrid, Nadia
Gosalbes, María José
Ron, Raquel
Dronda, Fernando
Pérez-Molina, José A.
Lanza, Val F.
Díaz, Jorge
Moreno, Santiago
Navia, Beatriz
Serrano-Villar, Sergio
Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
title Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
title_full Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
title_fullStr Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
title_full_unstemmed Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
title_short Relationship of Diet to Gut Microbiota and Inflammatory Biomarkers in People with HIV
title_sort relationship of diet to gut microbiota and inflammatory biomarkers in people with hiv
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954190/
https://www.ncbi.nlm.nih.gov/pubmed/35334878
http://dx.doi.org/10.3390/nu14061221
work_keys_str_mv AT manzanomonica relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT talaverarodriguezalba relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT morenoelena relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT madridnadia relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT gosalbesmariajose relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT ronraquel relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT drondafernando relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT perezmolinajosea relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT lanzavalf relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT diazjorge relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT morenosantiago relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT naviabeatriz relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv
AT serranovillarsergio relationshipofdiettogutmicrobiotaandinflammatorybiomarkersinpeoplewithhiv