Cargando…
Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population
Objectives: Arterial stiffness is widely accepted as an important predictor of cardiovascular disease (CVD) development. While obesity is generally associated with increased CVD risk, there is evidence that overweight patients with existing CVD may have better clinical outcomes than their lean count...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954212/ https://www.ncbi.nlm.nih.gov/pubmed/35323623 http://dx.doi.org/10.3390/jcdd9030075 |
_version_ | 1784676039080804352 |
---|---|
author | Zuo, Junli Tang, Biwen O’Rourke, Michael F. Avolio, Alberto P. Adji, Audrey |
author_facet | Zuo, Junli Tang, Biwen O’Rourke, Michael F. Avolio, Alberto P. Adji, Audrey |
author_sort | Zuo, Junli |
collection | PubMed |
description | Objectives: Arterial stiffness is widely accepted as an important predictor of cardiovascular disease (CVD) development. While obesity is generally associated with increased CVD risk, there is evidence that overweight patients with existing CVD may have better clinical outcomes than their lean counterparts. Our study sought to observe any potential association between brachial–ankle pulse wave velocity (BAPWV), a marker of arterial stiffness related to CVD risk, and Body Mass Index (BMI), a crude and widely used measure of obesity. Methods: Adult individuals (n = 857) assessed for routine CV risk were included and grouped according to their BMI (<25 kg/m(2): normal; 25–30 kg/m(2): overweight, ≥30 kg/m(2): obese). Their anthropometric parameters, brachial cuff pressures, and BAPWV were measured. Results: Brachial pressure was significantly higher as BMI increased. BAPWV showed a positive linear association with systolic (r = 0.66, p < 0.01), mean (r = 0.60, p < 0.01), diastolic (r = 0.51, p < 0.01), and pulse (r = 0.53, p < 0.01) pressures. However, a linear relationship between BMI and BAPWV was only apparent in males aged <50 years (p = 0.01) and in females aged ≥50 years (p < 0.01). In individuals with similar brachial systolic pressure, BAPWV was higher in normal-weight subjects compared to overweight–obese ones. Conclusions: This conflicting finding is attributed to an overestimation of the degree of arterial stiffness as a measure of CVD risk in individuals with a less ‘healthy’ BMI. This suggests that BMI may not the appropriate obesity indicator to assess CV risk. Our finding emphasizes the importance of establishing a non-linear relationship between CVD risk, age, and BMI, taking into account apparent sex differences, to predict future CV events. While this finding may suggest a lower degree of stiffness in large arteries of overweight–obese subjects compared to their normal-weight counterparts, the potential implications for individuals with higher BMI need be explored further. |
format | Online Article Text |
id | pubmed-8954212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-89542122022-03-26 Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population Zuo, Junli Tang, Biwen O’Rourke, Michael F. Avolio, Alberto P. Adji, Audrey J Cardiovasc Dev Dis Article Objectives: Arterial stiffness is widely accepted as an important predictor of cardiovascular disease (CVD) development. While obesity is generally associated with increased CVD risk, there is evidence that overweight patients with existing CVD may have better clinical outcomes than their lean counterparts. Our study sought to observe any potential association between brachial–ankle pulse wave velocity (BAPWV), a marker of arterial stiffness related to CVD risk, and Body Mass Index (BMI), a crude and widely used measure of obesity. Methods: Adult individuals (n = 857) assessed for routine CV risk were included and grouped according to their BMI (<25 kg/m(2): normal; 25–30 kg/m(2): overweight, ≥30 kg/m(2): obese). Their anthropometric parameters, brachial cuff pressures, and BAPWV were measured. Results: Brachial pressure was significantly higher as BMI increased. BAPWV showed a positive linear association with systolic (r = 0.66, p < 0.01), mean (r = 0.60, p < 0.01), diastolic (r = 0.51, p < 0.01), and pulse (r = 0.53, p < 0.01) pressures. However, a linear relationship between BMI and BAPWV was only apparent in males aged <50 years (p = 0.01) and in females aged ≥50 years (p < 0.01). In individuals with similar brachial systolic pressure, BAPWV was higher in normal-weight subjects compared to overweight–obese ones. Conclusions: This conflicting finding is attributed to an overestimation of the degree of arterial stiffness as a measure of CVD risk in individuals with a less ‘healthy’ BMI. This suggests that BMI may not the appropriate obesity indicator to assess CV risk. Our finding emphasizes the importance of establishing a non-linear relationship between CVD risk, age, and BMI, taking into account apparent sex differences, to predict future CV events. While this finding may suggest a lower degree of stiffness in large arteries of overweight–obese subjects compared to their normal-weight counterparts, the potential implications for individuals with higher BMI need be explored further. MDPI 2022-03-03 /pmc/articles/PMC8954212/ /pubmed/35323623 http://dx.doi.org/10.3390/jcdd9030075 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zuo, Junli Tang, Biwen O’Rourke, Michael F. Avolio, Alberto P. Adji, Audrey Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population |
title | Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population |
title_full | Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population |
title_fullStr | Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population |
title_full_unstemmed | Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population |
title_short | Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population |
title_sort | association between brachial-ankle pulse wave velocity as a marker of arterial stiffness and body mass index in a chinese population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954212/ https://www.ncbi.nlm.nih.gov/pubmed/35323623 http://dx.doi.org/10.3390/jcdd9030075 |
work_keys_str_mv | AT zuojunli associationbetweenbrachialanklepulsewavevelocityasamarkerofarterialstiffnessandbodymassindexinachinesepopulation AT tangbiwen associationbetweenbrachialanklepulsewavevelocityasamarkerofarterialstiffnessandbodymassindexinachinesepopulation AT orourkemichaelf associationbetweenbrachialanklepulsewavevelocityasamarkerofarterialstiffnessandbodymassindexinachinesepopulation AT avolioalbertop associationbetweenbrachialanklepulsewavevelocityasamarkerofarterialstiffnessandbodymassindexinachinesepopulation AT adjiaudrey associationbetweenbrachialanklepulsewavevelocityasamarkerofarterialstiffnessandbodymassindexinachinesepopulation |