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Quantitative Health Risk Assessment of the Chronic Inhalation of Chemical Compounds in Healthcare and Elderly Care Facilities

Previous studies have described the chemical pollution in indoor air of healthcare and care facilities. From these studies, the main objective of this work was to conduct a quantitative health risk assessment of the chronic inhalation of chemical compounds by workers in healthcare and elderly care f...

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Autores principales: Colas, Anaïs, Baudet, Alexandre, Le Cann, Pierre, Blanchard, Olivier, Gangneux, Jean-Pierre, Baurès, Estelle, Florentin, Arnaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954219/
https://www.ncbi.nlm.nih.gov/pubmed/35324766
http://dx.doi.org/10.3390/toxics10030141
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author Colas, Anaïs
Baudet, Alexandre
Le Cann, Pierre
Blanchard, Olivier
Gangneux, Jean-Pierre
Baurès, Estelle
Florentin, Arnaud
author_facet Colas, Anaïs
Baudet, Alexandre
Le Cann, Pierre
Blanchard, Olivier
Gangneux, Jean-Pierre
Baurès, Estelle
Florentin, Arnaud
author_sort Colas, Anaïs
collection PubMed
description Previous studies have described the chemical pollution in indoor air of healthcare and care facilities. From these studies, the main objective of this work was to conduct a quantitative health risk assessment of the chronic inhalation of chemical compounds by workers in healthcare and elderly care facilities (hospitals, dental and general practitioner offices, pharmacies and nursing homes). The molecules of interest were 36 volatile and 13 semi-volatile organic compounds. Several professional exposure scenarios were developed in these facilities. The likelihood and severity of side effects that could occur were assessed by calculating the hazard quotient for deterministic effects, and the excess lifetime cancer risk for stochastic effects. No hazard quotient was greater than 1. Three compounds had a hazard quotient above 0.1: 2-ethyl-1-hexanol in dental and general practitioner offices, ethylbenzene and acetone in dental offices. Only formaldehyde presented an excess lifetime cancer risk greater than 1 × 10(−5) in dental and general practitioner offices (maximum value of 3.8 × 10(−5) for general practitioners). The health risk for chronic inhalation of most compounds investigated did not appear to be of concern. Some values tend to approach the acceptability thresholds justifying a reflection on the implementation of corrective actions such as the installation of ventilation systems.
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spelling pubmed-89542192022-03-26 Quantitative Health Risk Assessment of the Chronic Inhalation of Chemical Compounds in Healthcare and Elderly Care Facilities Colas, Anaïs Baudet, Alexandre Le Cann, Pierre Blanchard, Olivier Gangneux, Jean-Pierre Baurès, Estelle Florentin, Arnaud Toxics Article Previous studies have described the chemical pollution in indoor air of healthcare and care facilities. From these studies, the main objective of this work was to conduct a quantitative health risk assessment of the chronic inhalation of chemical compounds by workers in healthcare and elderly care facilities (hospitals, dental and general practitioner offices, pharmacies and nursing homes). The molecules of interest were 36 volatile and 13 semi-volatile organic compounds. Several professional exposure scenarios were developed in these facilities. The likelihood and severity of side effects that could occur were assessed by calculating the hazard quotient for deterministic effects, and the excess lifetime cancer risk for stochastic effects. No hazard quotient was greater than 1. Three compounds had a hazard quotient above 0.1: 2-ethyl-1-hexanol in dental and general practitioner offices, ethylbenzene and acetone in dental offices. Only formaldehyde presented an excess lifetime cancer risk greater than 1 × 10(−5) in dental and general practitioner offices (maximum value of 3.8 × 10(−5) for general practitioners). The health risk for chronic inhalation of most compounds investigated did not appear to be of concern. Some values tend to approach the acceptability thresholds justifying a reflection on the implementation of corrective actions such as the installation of ventilation systems. MDPI 2022-03-15 /pmc/articles/PMC8954219/ /pubmed/35324766 http://dx.doi.org/10.3390/toxics10030141 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Colas, Anaïs
Baudet, Alexandre
Le Cann, Pierre
Blanchard, Olivier
Gangneux, Jean-Pierre
Baurès, Estelle
Florentin, Arnaud
Quantitative Health Risk Assessment of the Chronic Inhalation of Chemical Compounds in Healthcare and Elderly Care Facilities
title Quantitative Health Risk Assessment of the Chronic Inhalation of Chemical Compounds in Healthcare and Elderly Care Facilities
title_full Quantitative Health Risk Assessment of the Chronic Inhalation of Chemical Compounds in Healthcare and Elderly Care Facilities
title_fullStr Quantitative Health Risk Assessment of the Chronic Inhalation of Chemical Compounds in Healthcare and Elderly Care Facilities
title_full_unstemmed Quantitative Health Risk Assessment of the Chronic Inhalation of Chemical Compounds in Healthcare and Elderly Care Facilities
title_short Quantitative Health Risk Assessment of the Chronic Inhalation of Chemical Compounds in Healthcare and Elderly Care Facilities
title_sort quantitative health risk assessment of the chronic inhalation of chemical compounds in healthcare and elderly care facilities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954219/
https://www.ncbi.nlm.nih.gov/pubmed/35324766
http://dx.doi.org/10.3390/toxics10030141
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